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pro vyhledávání: '"Menno Hofman"'
Autor:
Maaike Schillemans, Marije Kat, Jurjen Westeneng, Anastasia Gangaev, Menno Hofman, Benjamin Nota, Floris P. J. van Alphen, Martin de Boer, Maartje van den Biggelaar, Coert Margadant, Jan Voorberg, Ruben Bierings
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 3, Iss 4, Pp 718-732 (2019)
Abstract Background Synthesis of the hemostatic protein von Willebrand factor (VWF) drives formation of endothelial storage organelles called Weibel‐Palade bodies (WPBs). In the absence of VWF, angiogenic and inflammatory mediators that are costore
Externí odkaz:
https://doaj.org/article/f5bad20c9eee478db4af6502d1df88c3
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The non-selective mechanosensitive ion channel PIEZO1 controls erythrocyte volume homeostasis. Different missense gain-of-function mutations in PIEZO1 gene have been identified that cause Hereditary Xerocytosis (HX), a rare autosomal dominant haemoly
Externí odkaz:
https://doaj.org/article/af06a48afd7b4a559d8f71cf235b7fb7
Autor:
Ellie Karampini, Maaike Schillemans, Menno Hofman, Floris van Alphen, Martin de Boer, Taco W. Kuijpers, Maartje van den Biggelaar, Jan Voorberg, Ruben Bierings
Publikováno v:
Haematologica, Vol 104, Iss 10 (2019)
Weibel-Palade bodies are endothelial secretory organelles that contain von Willebrand factor, P-selectin and CD63. Release of von Willebrand factor from Weibel-Palade bodies is crucial for platelet adhesion during primary hemostasis. Endosomal traffi
Externí odkaz:
https://doaj.org/article/b755cb5368fd49358bfd47c0b9846cab
Autor:
Javier Martin-Ramirez, Maayke G M Kok, Menno Hofman, Ruben Bierings, Esther E Creemers, Joost C M Meijers, Jan Voorberg, Sara-Joan Pinto-Sietsma
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99890 (2014)
BackgroundTo study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells (BOECs) of patients with premature CAD and their first degree relatives (FDR). Additionally
Externí odkaz:
https://doaj.org/article/8dd3ffb311cb49b8b7e49f935ec63a9e
Autor:
Marije Kat, Iris van Moort, Petra E. Bürgisser, Taco W. Kuijpers, Menno Hofman, Marie Favier, Rémi Favier, Coert Margadant, Jan Voorberg, Ruben Bierings
Publikováno v:
Research and practice in thrombosis and haemostasis, 7(2):100086. Wiley-Blackwell Publishing Ltd
Research and Practice in Thrombosis and Haemostasis, 7(2):100086. Wiley-Blackwell Publishing Ltd
Kat, M, van Moort, I, Bürgisser, P E, Kuijpers, T W, Hofman, M, Favier, M, Favier, R M, Margadant, C, Voorberg, J & Bierings, R 2023, ' Mutations in Neurobeachin-like 2 do not impact Weibel-Palade body biogenesis and von Willebrand factor secretion in gray platelet syndrome Endothelial Colony Forming Cells ', Research and practice in thrombosis and haemostasis, vol. 7, no. 2, 100086 . https://doi.org/10.1016/j.rpth.2023.100086
Research and Practice in Thrombosis and Haemostasis, 7(2):100086. Wiley-Blackwell Publishing Ltd
Kat, M, van Moort, I, Bürgisser, P E, Kuijpers, T W, Hofman, M, Favier, M, Favier, R M, Margadant, C, Voorberg, J & Bierings, R 2023, ' Mutations in Neurobeachin-like 2 do not impact Weibel-Palade body biogenesis and von Willebrand factor secretion in gray platelet syndrome Endothelial Colony Forming Cells ', Research and practice in thrombosis and haemostasis, vol. 7, no. 2, 100086 . https://doi.org/10.1016/j.rpth.2023.100086
Background: Patients with gray platelet syndrome (GPS) and Neurobeachin-like 2 (NBEAL2) deficiency produce platelets lacking alpha-granules (AGs) and present with lifelong bleeding symptoms. AGs are lysosome-related organelles and store the hemostati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664091d35cf28063796c19ea5cd5628d
https://pure.amc.nl/en/publications/mutations-in-neurobeachinlike-2-do-not-impact-weibelpalade-body-biogenesis-and-von-willebrand-factor-secretion-in-gray-platelet-syndrome-endothelial-colony-forming-cells(6c9f3553-7728-49d7-b147-ceaa2773a5d6).html
https://pure.amc.nl/en/publications/mutations-in-neurobeachinlike-2-do-not-impact-weibelpalade-body-biogenesis-and-von-willebrand-factor-secretion-in-gray-platelet-syndrome-endothelial-colony-forming-cells(6c9f3553-7728-49d7-b147-ceaa2773a5d6).html
Autor:
Marije Kat, Iris van Moort, Petra E. Bürgisser, Taco W. Kuijpers, Menno Hofman, Marie Favier, Rémi Favier, Coert Margadant, Jan Voorberg, Ruben Bierings
BackgroundGray Platelet Syndrome (GPS) patients with Neurobeachin-like 2 (NBEAL2) deficiency produce platelets lacking alpha-granules (AGs) and present with lifelong bleeding symptoms. AGs are lysosome-related organelles (LROs) and store the hemostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9ef7d613ecf4d8d48358536ae95aa63
https://doi.org/10.1101/2022.06.08.495181
https://doi.org/10.1101/2022.06.08.495181
Autor:
Benjamin Nota, Jan Voorberg, Anastasia Gangaev, Maartje van den Biggelaar, Martin de Boer, Marije Kat, Maaike Schillemans, Jurjen Westeneng, Menno Hofman, Floris P. J. van Alphen, Ruben Bierings, Coert Margadant
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, 3(4), 718-732. Wiley-Blackwell Publishing Ltd
Research and Practice in Thrombosis and Haemostasis, Vol 3, Iss 4, Pp 718-732 (2019)
Research and practice in thrombosis and haemostasis, 3(4), 718-732. Wiley-Blackwell Publishing Ltd
Research and Practice in Thrombosis and Haemostasis
Research and Practice in Thrombosis and Haemostasis, Vol 3, Iss 4, Pp 718-732 (2019)
Research and practice in thrombosis and haemostasis, 3(4), 718-732. Wiley-Blackwell Publishing Ltd
Research and Practice in Thrombosis and Haemostasis
textabstractBackground: Synthesis of the hemostatic protein von Willebrand factor (VWF) drives formation of endothelial storage organelles called Weibel‐Palade bodies (WPBs). In the absence of VWF, angiogenic and inflammatory mediators that are cos
Autor:
Johanna C. Escher, Jan Voorberg, Bart L. van den Eshof, Rüdiger Adam, Hans Janssen, Tom Carter, Maartje van den Biggelaar, Anastasia Gangaev, Aat A. Mulder, Ellie Karampini, Henriet Meems, Maaike Schillemans, Menno Hofman, Ruben Bierings, Abraham J. Koster, Dorothee van Breevoort, Carolina R. Jost
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis Thrombosis & Vascular Biology, 38(7), 1549-1561. Lippincott Williams & Wilkins
Arteriosclerosis, Thrombosis, and Vascular Biology, 38(7), 1549-1561
Arteriosclerosis, thrombosis, and vascular biology, 38(7), 1549-1561. Lippincott Williams and Wilkins
Arteriosclerosis Thrombosis & Vascular Biology, 38(7), 1549-1561. Lippincott Williams & Wilkins
Arteriosclerosis, Thrombosis, and Vascular Biology, 38(7), 1549-1561
Arteriosclerosis, thrombosis, and vascular biology, 38(7), 1549-1561. Lippincott Williams and Wilkins
Supplemental Digital Content is available in the text.
Objective— Endothelial cells store VWF (von Willebrand factor) in rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs). WPB exocytosis is coordinated by a complex network of
Objective— Endothelial cells store VWF (von Willebrand factor) in rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs). WPB exocytosis is coordinated by a complex network of
Autor:
M. von Lindern, Patrick Burger, E. van den Akker, M. Hansen, Tatjana Wüst, Eszter Varga, Steven Heshusius, Menno Hofman
Publikováno v:
HemaSphere. 3:562
Autor:
Jan Voorberg, Maartje van den Biggelaar, Menno Hofman, Javier Martin-Ramirez, Robert P. Hebbel
Publikováno v:
Nature protocols, 7(9), 1709-1715. Nature Publishing Group
Blood outgrowth endothelial cells (BOECs) are important tools when investigating diagnostic and therapeutic approaches for vascular disease. In this protocol, mononuclear cells are isolated from peripheral blood and plated on type I collagen at simil