Výsledky vyhledávání - "Menno A. W. G. van der Hoorn"

Generation and administration of HA-1-specific T-cell lines for the treatment of patients with relapsed leukemia after allogeneic stem cell transplantation: a pilot study

Autor: Roel Willemze, Pauline Meij, J.H. Frederik Falkenburg, Linda Cox, Rian Bongaerts, Erik W.A. Marijt, Amon R. Wafelman, Inge Jedema, Menno A. W. G. van der Hoorn

Publikováno v: Haematologica, 97(8), 1205-1208

Since HA-1-specific T cells have been shown to make a significant contribution to the clinical responses in patients with relapsed leukemia, we investigated the feasibility of adoptive transfer of in vitro induced HA-1-specific CD8 positive T cells t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c50d139ef13e325bfa7d1602f0a1b5b
https://doi.org/10.3324/haematol.2011.053371

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Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application

Autor: Nikolai Schwabe, Menno A. W. G. van der Hoorn, Michel G.D. Kester, J.H. Frederik Falkenburg, Marieke Griffioen, H. M. Esther van Egmond, Mirjam H.M. Heemskerk, Roel Willemze, Renate S. Hagedoorn, Helen E. Barnby-Porritt

Publikováno v: Haematologica. 93:1535-1543

Background Donor lymphocyte infusion is an effective form of adoptive immunotherapy for hematologic malignancies after allogeneic stem cell transplantation. Graft-versus-host disease, however, often develops due to recognition of ubiquitously-express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8896faa43a432803a160e77fab5e51
https://doi.org/10.3324/haematol.13067

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Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex

Autor: Roel Willemze, J.H. Frederik Falkenburg, Manja Hoogeboom, Renate S. Hagedoorn, Lars T. van der Veken, Menno A. W. G. van der Hoorn, Michel G.D. Kester, Mirjam H.M. Heemskerk

Publikováno v: Blood. 109:235-243

Genetic engineering of T lymphocytes is an attractive strategy to specifically redirect T-cell immunity toward viral infections and malignancies. We previously demonstrated redirected antileukemic reactivity of cytomegalovirus (CMV)–specific T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5f1d35623fd4ce144668774a934dbf
https://doi.org/10.1182/blood-2006-03-013318

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Redirection of antileukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region

Autor: Roelof A. de Paus, Mirjam H.M. Heemskerk, Els Goulmy, J.H. Frederik Falkenburg, Roel Willemze, Menno A. W. G. van der Hoorn, Michel G.D. Kester, Manja Hoogeboom

Publikováno v: Blood. 102:3530-3540

Donor-derived T lymphocytes directed against minor histocompatibility antigens (mHags) exclusively expressed on cells of the hematopoietic lineages can eliminate hematologic malignancies. Transfer of T-cell receptors (TCRs) directed against these mHa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ee884897d0677bc9f924ac69f13719
https://doi.org/10.1182/blood-2003-05-1524

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Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia

Autor: Freke M. Kloosterboer, Mirjam H.M. Heemskerk, Jan W. Drijfhout, Menno A. W. G. van der Hoorn, Michel G.D. Kester, Simone A. P. van Luxemburg-Heys, Manja Hoogeboom, Tuna Mutis, Els Goulmy, W. A. Erik Marijt, J. H. Frederik Falkenburg, Roel Willemze, Jon J. van Rood

Publikováno v: Proceedings of the National Academy of Sciences. 100:2742-2747

Donor lymphocyte infusion (DLI) into patients with a relapse of their leukemia or multiple myeloma after allogeneic stem cell transplantation (alloSCT) has been shown to be a successful treatment approach. The hematopoiesis-restricted minor histocomp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1bc8956d96b8a82982f31a9a07c073
https://doi.org/10.1073/pnas.0530192100

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The generation of dendritic-like cells with increased allostimulatory function from acute myeloid leukemia cells of various FAB subclasses

Autor: Hanneke C. Kluin-Nelemans, Shama L. van Zelderen-Bhola, Menno A. W. G. van der Hoorn, J.H. Frederik Falkenburg, Roel Willemze, Rolf E. Brouwer

Publikováno v: Brouwer, R E, Van Der Hoorn, M, Kluin-Nelemans, H C, Van Zelderen-Bhola, S, Willemze, R & Falkenburg, J H F 2000, ' The generation of dendritic-like cells with increased allostimulatory function from acute myeloid leukemia cells of various FAB subclasses ', Human Immunology, vol. 61, no. 6, pp. 565-574 . https://doi.org/10.1016/S0198-8859(00)00111-7
Human Immunology, 61(6), 565-574. Elsevier Inc.

To increase the immunogenicity of leukemic cells, attempts were made to generate dendritic-like antigen presenting cells (DC) from AML blasts from 14 patients with AML FAB classifications M0-M5. Leukemic cells were cultured in the presence or absence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683391c9cc92cd1b461ccec3bb66af04
https://doi.org/10.1016/s0198-8859(00)00111-7

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Functional analysis of killer Ig-like receptor-expressing cytomegalovirus-specific CD8+ T cells

Autor: J.H. Frederik Falkenburg, Jeroen van Bergen, Mirjam H.M. Heemskerk, Maria Diez Campelo, Menno A. W. G. van der Hoorn, H. M. Esther van Egmond, Roel Willemze, Lars T. van der Veken, Renate S. Hagedoorn

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 182(1)

Killer Ig-like receptors (KIR) are expressed by human NK cells and T cells. Although Ag-specific cytolytic activity and cytokine production of KIR+ T cells can be inhibited by KIR ligation, the effect of KIR on proliferation is unclear. KIR+ T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f81eb8b7ee654ae64d604adb25fb56
https://pubmed.ncbi.nlm.nih.gov/19109139

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T Cell Receptor Gene Transfer to Virus-Specific T Cells for Cellular Anti-Tumor Immunotherapy

Autor: J.H. Frederik Falkenburg, Menno A. W. G. van der Hoorn, Michel G.D. Kester, Renate S. Hagedoorn, Roelof Willemze, H. M. Esther van Egmond, Mirjam H.M. Heemskerk, Marieke Griffioen

Publikováno v: Blood. 110:2594-2594

Patients with relapsed hematological malignancies after allogeneic stem cell transplantation (alloSCT) can be successfully treated by donor lymphocyte infusions (DLI). Since DLI consists of a variety of T cells with different specificities, the benif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27e7d4f71a47608cf2a10909e1138e05
https://doi.org/10.1182/blood.v110.11.2594.2594

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GVHD in HLA-A2 Mismatched Transplantation Caused by a Combined CD8 Response Directed Against HLA-A2 and a CD4 Response Recognizing an HLA-A2 Derived Peptide in HLA-DR1

Autor: Erik W.A. Marijt, Roelof Willemze, J.H. Frederik Falkenburg, Menno A. W. G. van der Hoorn, Michel G.D. Kester, Avital L. Amir, Mirjam H.M. Heemskerk

Publikováno v: Blood. 108:5164-5164

HLA mismatched Stem Cell Transplantation (SCT) can be performed in patients with leukemia if no HLA identical donor can be found. Although HLA class I is expressed by almost all recipient cells and the frequency of allo-HLA reactive T-cells is high i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74d2eb664aa9769c3279ac43e48ebfc2
https://doi.org/10.1182/blood.v108.11.5164.5164

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