Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Menna R. Clatworthy"'
Autor:
Ayshwarya Subramanian, Katherine A. Vernon, Yiming Zhou, Jamie L. Marshall, Maria Alimova, Carlos Arevalo, Fan Zhang, Michal Slyper, Julia Waldman, Monica S. Montesinos, Danielle Dionne, Lan T. Nguyen, Michael S. Cuoco, Dan Dubinsky, Jason Purnell, Keith Keller, Samuel H. Sturner, Elizabeth Grinkevich, Ayan Ghoshal, Amanda Kotek, Giorgio Trivioli, Nathan Richoz, Mary B. Humphrey, Isabella G. Darby, Sarah J. Miller, Yingping Xu, Astrid Weins, Alexandra Chloe-Villani, Steven L. Chang, Matthias Kretzler, Orit Rosenblatt-Rosen, Jillian L. Shaw, Kurt A. Zimmerman, Menna R. Clatworthy, Aviv Regev, Anna Greka
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114253- (2024)
Summary: Diabetic kidney disease (DKD), the most common cause of kidney failure, is a frequent complication of diabetes and obesity, and yet to date, treatments to halt its progression are lacking. We analyze kidney single-cell transcriptomic profile
Externí odkaz:
https://doaj.org/article/c26ba69a6afe47bdbc7deb8408bb9ad1
Autor:
Colin Y. C. Lee, Bethany C. Kennedy, Nathan Richoz, Isaac Dean, Zewen K. Tuong, Fabrina Gaspal, Zhi Li, Claire Willis, Tetsuo Hasegawa, Sarah K. Whiteside, David A. Posner, Gianluca Carlesso, Scott A. Hammond, Simon J. Dovedi, Rahul Roychoudhuri, David R. Withers, Menna R. Clatworthy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an activation programme enriched in regulatory molecule expression, inclu
Externí odkaz:
https://doaj.org/article/a9dead2996844a5bb3e43c7e6aa7f935
Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity
Autor:
Isaac Dean, Colin Y. C. Lee, Zewen K. Tuong, Zhi Li, Christopher A. Tibbitt, Claire Willis, Fabrina Gaspal, Bethany C. Kennedy, Veronika Matei-Rascu, Rémi Fiancette, Caroline Nordenvall, Ulrik Lindforss, Syed Murtuza Baker, Christian Stockmann, Veronika Sexl, Scott A. Hammond, Simon J. Dovedi, Jenny Mjösberg, Matthew R. Hepworth, Gianluca Carlesso, Menna R. Clatworthy, David R. Withers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of cancer progression. Established tumors contain phenotypically distinct, tumor-specific natural killer (NK) cells; however, the temporal dynamics, mecha
Externí odkaz:
https://doaj.org/article/27d36aa7031e441daba36d10fc106a98
Autor:
Ondrej Suchanek, John R. Ferdinand, Zewen K. Tuong, Sathi Wijeyesinghe, Anita Chandra, Ann-Katrin Clauder, Larissa N. Almeida, Simon Clare, Katherine Harcourt, Christopher J. Ward, Rachael Bashford-Rogers, Trevor Lawley, Rudolf A. Manz, Klaus Okkenhaug, David Masopust, Menna R. Clatworthy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract B cells play a central role in humoral immunity but also have antibody-independent functions. Studies to date have focused on B cells in blood and secondary lymphoid organs but whether B cells reside in non-lymphoid organs (NLO) in homeostas
Externí odkaz:
https://doaj.org/article/c0d8e43c40604f7b822a7676214f0253
Autor:
Jacob Hepkema, Nicholas Keone Lee, Benjamin J. Stewart, Siwat Ruangroengkulrith, Varodom Charoensawan, Menna R. Clatworthy, Martin Hemberg
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract The binding of transcription factors at proximal promoters and distal enhancers is central to gene regulation. Identifying regulatory motifs and quantifying their impact on expression remains challenging. Using a convolutional neural network
Externí odkaz:
https://doaj.org/article/adb1c4ecc9f94a289b4b957c56315882
Autor:
Akimichi Inaba, Zewen Kelvin Tuong, Tian X. Zhao, Andrew P. Stewart, Rebeccah Mathews, Lucy Truman, Rouchelle Sriranjan, Jane Kennet, Kourosh Saeb-Parsy, Linda Wicker, Frank Waldron-Lynch, Joseph Cheriyan, John A. Todd, Ziad Mallat, Menna R. Clatworthy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Dysfunction of interleukin-10 producing regulatory B cells has been associated with the pathogenesis of autoimmune diseases, but whether regulatory B cells can be therapeutically induced in humans is currently unknown. Here we demonstrate th
Externí odkaz:
https://doaj.org/article/733547fe76a040a4be8f3da2878d86c9
Autor:
Ethan G. Dutcher, Laura Lopez-Cruz, E. A. Claudia Pama, Mary-Ellen Lynall, Iris C. R. Bevers, Jolyon A. Jones, Shahid Khan, Stephen J. Sawiak, Amy L. Milton, Menna R. Clatworthy, Trevor W. Robbins, Edward T. Bullmore, Jeffrey W. Dalley
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Early-life stress (ELS) or adversity, particularly in the form of childhood neglect and abuse, is associated with poor mental and physical health outcomes in adulthood. However, whether these relationships are mediated by the consequences of
Externí odkaz:
https://doaj.org/article/fd561f9d616d4904bddd36a9d6dd5cec
Autor:
Ondrej Suchanek, Menna R. Clatworthy
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
To date, studies of tissue-resident immunity have mainly focused on innate immune cells and T cells, with limited data on B cells. B-1 B cells are a unique subset of B cells with innate-like properties, enriched in murine pleural and peritoneal cavit
Externí odkaz:
https://doaj.org/article/3ba0f2690fd840f4a114edea76f2c428
Autor:
Mary-Ellen Lynall, Blagoje Soskic, James Hayhurst, Jeremy Schwartzentruber, Daniel F. Levey, Gita A. Pathak, Renato Polimanti, Joel Gelernter, Murray B. Stein, Gosia Trynka, Menna R. Clatworthy, Ed Bullmore
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The role of the immune system in the pathogenesis of psychiatric disorders is unclear. Here, the authors show that genetic risk variants for multiple psychiatric disorders are enriched in regions of the genome active in the brain and in lymphoid cell
Externí odkaz:
https://doaj.org/article/d1df8320185840709531e2913302934e
Autor:
Isabella A.T.M. Ferreira, Colin Y.C. Lee, William S. Foster, Adam Abdullahi, Lisa M. Dratva, Zewen Kelvin Tuong, Benjamin J. Stewart, John R. Ferdinand, Stephane M. Guillaume, Martin O.P. Potts, Marianne Perera, Benjamin A. Krishna, Ana Peñalver, Mia Cabantous, Steven A. Kemp, Lourdes Ceron-Gutierrez, Soraya Ebrahimi, Paul Lyons, Kenneth G.C. Smith, John Bradley, Dami A. Collier, Laura E. McCoy, Agatha van der Klaauw, James E.D. Thaventhiran, I. Sadaf Farooqi, Sarah A. Teichmann, Paul A. MacAry, Rainer Doffinger, Mark R. Wills, Michelle A. Linterman, Menna R. Clatworthy, Ravindra K. Gupta
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112991- (2023)
Summary: Suboptimal responses to a primary vaccination course have been reported in the elderly, but there is little information regarding the impact of age on responses to booster third doses. Here, we show that individuals 70 years or older (median
Externí odkaz:
https://doaj.org/article/ae089416071a4557966b754f87892413