Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19.

Autor: Rong Z; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Munich Medical Research School (MMRS), Munich, Germany., Mai H; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China; Munich Medical Research School (MMRS), Munich, Germany., Ebert G; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany; German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany., Kapoor S; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Puelles VG; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark., Czogalla J; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hu S; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Su J; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany., Prtvar D; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Singh I; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Munich, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Schädler J; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Delbridge C; Institute of Pathology, Division of Neuropathology, School of Medicine, Technical University of Munich, Munich, Germany., Steinke H; Institute of Anatomy, University of Leipzig, Leipzig, Germany., Frenzel H; Institute of Anatomy, University of Leipzig, Leipzig, Germany., Schmidt K; Institute of Anatomy, University of Leipzig, Leipzig, Germany., Braun C; Institute of Legal Medicine, Ludwig-Maximilians-University Munich, Munich, Germany., Bruch G; Institute of Legal Medicine, Ludwig-Maximilians-University Munich, Munich, Germany., Ruf V; Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Ali M; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Graduate School of Neuroscience (GSN), Munich, Germany., Sühs KW; Department of Neurology, Medical School Hannover, Hannover, Germany., Nemati M; Department of Neurology, Ludwig-Maximilians-University Munich, Munich, Germany., Hopfner F; Department of Neurology, Ludwig-Maximilians-University Munich, Munich, Germany., Ulukaya S; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany., Jeridi D; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany., Mistretta D; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany., Caliskan ÖS; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany., Wettengel JM; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany., Cherif F; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Kolabas ZI; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Graduate School of Neuroscience (GSN), Munich, Germany., Molbay M; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Munich Medical Research School (MMRS), Munich, Germany., Horvath I; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Center of Doctoral Studies in Informatics and its Applications (CEDOSIA), Technical University of Munich, Munich, Germany., Zhao S; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Krahmer N; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany., Yildirim AÖ; Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Ussar S; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Munich, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Herms J; Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Huber TB; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Tahirovic S; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Schwarzmaier SM; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Plesnila N; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Höglinger G; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; Department of Neurology, Ludwig-Maximilians-University Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Ondruschka B; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bechmann I; Institute of Anatomy, University of Leipzig, Leipzig, Germany., Protzer U; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany; German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany., Elsner M; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany., Bhatia HS; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Hellal F; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Ertürk A; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Koç University, School of Medicine, İstanbul, Turkey. Electronic address: ali.erturk@helmholtz-munich.de.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2024 Dec 11; Vol. 32 (12), pp. 2112-2130.e10. Date of Electronic Publication: 2024 Nov 29.

Upregulation of delta opioid receptor by meningeal interleukin-10 prevents relapsing pain.

Autor: Inyang KE; Department of Physiology, Michigan State University, East Lansing, MI, USA., Sim J; Department of Physiology, Michigan State University, East Lansing, MI, USA; Cell and Molecular Biology Graduate Program, Michigan State University, East Lansing, MI, USA., Clark KB; Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Geron M; Department of Cell Biology and Physiology, Department of Pharmacology, UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC, USA., Monahan K; Department of Physiology, Michigan State University, East Lansing, MI, USA., Evans C; Department of Physiology, Michigan State University, East Lansing, MI, USA., O'Connell P; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA., Laumet S; Department of Physiology, Michigan State University, East Lansing, MI, USA., Peng B; Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ma J; Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Heijnen CJ; Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dantzer R; Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Scherrer G; Department of Cell Biology and Physiology, Department of Pharmacology, UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC, USA; New York Stem Cell Foundation - Robertson Investigator, University of North Carolina, Chapel Hill, NC, USA., Kavelaars A; Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bernard M; Flow Cytometry Core, Michigan State University, East Lansing, MI, USA., Aldhamen YA; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA., Folger JK; Department of Physiology, Michigan State University, East Lansing, MI, USA., Bavencoffe A; Department of Integrative Biology and Pharmacology, McGovern Medical School at UTHealth, Houston, TX, USA., Laumet G; Department of Physiology, Michigan State University, East Lansing, MI, USA; Cell and Molecular Biology Graduate Program, Michigan State University, East Lansing, MI, USA; Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: laumetge@msu.edu.

Publikováno v: Brain, behavior, and immunity [Brain Behav Immun] 2025 Jan; Vol. 123, pp. 399-410. Date of Electronic Publication: 2024 Sep 29.

TRESK channel activation ameliorates migraine-like pain via modulation of CGRP release from the trigeminovascular system and meningeal mast cells in experimental migraine models.

Autor: Torun IE; Department of Physiology, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu, Türkiye., Kilinc YB; Department of Pediatrics, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu, Türkiye., Kilinc E; Department of Physiology, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu, Türkiye. Electronic address: erkankilinc@ibu.edu.tr., Töre F; Department of Physiology, Faculty of Medicine, Istanbul Atlas University, Istanbul, Türkiye.

Publikováno v: Life sciences [Life Sci] 2024 Nov 15; Vol. 357, pp. 123091. Date of Electronic Publication: 2024 Oct 01.

Meningeal brain borders and migraine headache genesis.

Autor: Christensen SL; Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Neurology, Danish Headache Center, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark; Translational Research Centre, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark., Levy D; Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: dlevy1@bidmc.harvard.edu.

Publikováno v: Trends in neurosciences [Trends Neurosci] 2024 Nov; Vol. 47 (11), pp. 918-932. Date of Electronic Publication: 2024 Sep 19.

Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior.

Autor: Barron JJ; Department of Psychiatry and Behavioral Sciences-Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA., Mroz NM; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94158, USA., Taloma SE; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA.; Kavli Institute for Fundamental Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA., Dahlgren MW; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94158, USA.; Lung Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden., Ortiz-Carpena JF; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94158, USA., Keefe MG; Department of Psychiatry and Behavioral Sciences-Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA., Escoubas CC; Department of Psychiatry and Behavioral Sciences-Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Dorman LC; Department of Psychiatry and Behavioral Sciences-Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA., Vainchtein ID; Department of Psychiatry and Behavioral Sciences-Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Chiaranunt P; Department of Psychiatry and Behavioral Sciences-Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94158, USA., Kotas ME; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA., Nowakowski TJ; Department of Psychiatry and Behavioral Sciences-Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA., Bender KJ; Kavli Institute for Fundamental Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA., Molofsky AB; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94158, USA., Molofsky AV; Department of Psychiatry and Behavioral Sciences-Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.; Kavli Institute for Fundamental Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Nov; Vol. 386 (6721), pp. eadi1025. Date of Electronic Publication: 2024 Nov 01.