Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Mengzhu Tan"'
Autor:
Mengru Gu, Hanlu Jiang, Mengzhu Tan, Long Yu, Ning Xu, Ying Li, Han Wu, Qing Hou, Chunsun Dai
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract palmitoylation, a reversible post-translational modification, is initiated by the DHHC family of palmitoyltransferases and reversed by several acyl protein thioesterases. However, the role and mechanisms for protein palmitoylation in renal f
Externí odkaz:
https://doaj.org/article/093e8996f2ad4b94be8d372f694bd7cd
Autor:
Xian Xue, Xingwen Zhu, Lu Zhou, Xiaoli Sun, Mengru Gu, Yan Liang, Mengzhu Tan, Qing Hou, Sudan Wang, Chunsun Dai
Publikováno v:
Kidney Diseases, Pp 1-1 (2024)
Introduction: Transcriptional coactivator with PDZ-binding motif (TAZ), a Hippo signaling pathway effector, maintains the balance of cell proliferation, differentiation, and death. However, the role of TAZ in tubular cell survival and acute kidney in
Externí odkaz:
https://doaj.org/article/433362468658463080c44a3023672490
Autor:
Lu Zhou, Qingmiao Lu, Sudan Wang, Chunsun Dai, Yan Liang, Qing Hou, Mingjie Wang, Xiaoli Sun, Mengru Gu, Mengzhu Tan, Xian Xue
Publikováno v:
Cell Death and Differentiation
Macrophage accumulation and activation play an essential role in kidney fibrosis; however, the underlying mechanisms remain to be explored. By analyzing the kidney tissues from patients and animal models with kidney fibrosis, we found a large inducti
Autor:
Mengru Gu, Mengzhu Tan, Lu Zhou, Xiaoli Sun, Qingmiao Lu, Mingjie Wang, Hanlu Jiang, Yan Liang, Qing Hou, Xian Xue, Zhuo Xu, Chunsun Dai
Publikováno v:
Kidney international. 102(2)
Energy metabolism is crucial in maintaining cellular homeostasis and adapting to stimuli for tubular cells. However, the underlying mechanisms remain largely unknown. Here, we report that PP2Acα was upregulated in damaged tubular cells from patients
Publikováno v:
Cellular Signalling. 90:110187
Protein Phosphatase 2A (PP2A), a main serine/threonine phosphatase, plays a profibrotic role in the development of different organs. However, the role and mechanisms of PP2Acα in fibroblast activation and kidney fibrosis are not fully known. Here we