Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mengtian Ren"'
Autor:
Mengtian Ren, Fabian Gut, Yilan Fan, Jingke Ma, Xiajing Shan, Aysenur Yikilmazsoy, Mariia Likhodeeva, Karl-Peter Hopfner, Chuanzheng Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Base excision repair (BER) is initialized by DNA glycosylases, which recognize and flip damaged bases out of the DNA duplex into the enzymes active site, followed by cleavage of the glycosidic bond. Recent studies have revealed that all type
Externí odkaz:
https://doaj.org/article/ab826eb8c1d04ac08415a61b311a6343
Autor:
Huawei Wang, Chuanlong Zang, Mengtian Ren, Mengdi Shang, Zhenghua Wang, Xuemei Peng, Qiangzhe Zhang, Xin Wen, Zhen Xi, Chuanzheng Zhou
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract The nucleosome is the basic structural repeating unit of chromatin. DNA damage and cell apoptosis release nucleosomes into the blood circulatory system, and increased levels of circulating nucleosomes have been observed to be related to infl
Externí odkaz:
https://doaj.org/article/345f0b8324f74affa56dc279827d5908
Publikováno v:
Acc Chem Res
DNA is damaged by various endogenous and exogenous sources, leading to a diverse group of reactive intermediates that yield a complex mixture of products. The initially formed products are often metastable and can react to yield lesions that are more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ac8a69e828b8869d371c6a63d32e40
https://pubmed.ncbi.nlm.nih.gov/35271268
https://pubmed.ncbi.nlm.nih.gov/35271268
Publikováno v:
Nucleic Acids Research
DNA damage and apoptosis lead to the release of free nucleosomes—the basic structural repeating units of chromatin—into the blood circulation system. We recently reported that free nucleosomes that enter the cytoplasm of mammalian cells trigger i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b45f2efe297f979d7fe2c67e59e706
https://doi.org/10.1093/nar/gkab1121
https://doi.org/10.1093/nar/gkab1121
Publikováno v:
ChemMedChem. 17(2)
The cGAS-STING pathway discovered ten years ago is an important component of the innate immune system. Activation of cGAS-STING triggers downstream signalling, such as TBK1-IRF3, NF-κB and autophagy, which in turn leads to antipathogen responses, du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92dfa00d40c29f692bb60842626b4ce4
https://pubmed.ncbi.nlm.nih.gov/34807508
https://pubmed.ncbi.nlm.nih.gov/34807508
Publikováno v:
Chemical Research in Toxicology. 32:926-934
Ribonucleotides can be incorporated into DNA through many different cellular processes, and abundant amounts of ribonucleotides are detected in genomic DNA. Embedded ribonucleotides lead to genomic instability through either spontaneous ribonucleotid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6020cac1e87bab6b72bea88457c874
https://doi.org/10.1021/acs.chemrestox.9b00059
https://doi.org/10.1021/acs.chemrestox.9b00059
Publikováno v:
Science China Chemistry. 62:561-570
Eukaryotic genomic DNA is packed into chromatin, whose fundamental structural unit is the nucleosome. As DNA-histone protein complexes, nucleosomes show different properties toward exogenous and endogenous DNA-damaging agents. This review summarizes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b675dafa2867b7145e6271da295a2fe
https://doi.org/10.1007/s11426-018-9421-5
https://doi.org/10.1007/s11426-018-9421-5
Publikováno v:
Nucleic Acids Research
8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) is a biomarker of oxidative DNA damage and can be repaired by hOGG1 and APE1 via the base excision repair (BER) pathway. In this work, we studied coordinated BER of 8-oxodGuo by hOGG1 and APE1 in nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c92f295c28e8c93145e97a89e7cecb1
https://pubmed.ncbi.nlm.nih.gov/33290564
https://pubmed.ncbi.nlm.nih.gov/33290564
Autor:
Chuanlong Zang, Mengtian Ren, Qiang-Zhe Zhang, Mengdi Shang, Xuemei Peng, Zhenghua Wang, Xin Wen, Chuanzheng Zhou, Zhen Xi, Huawei Wang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
The nucleosome is the basic structural repeating unit of chromatin. DNA damage and cell apoptosis release nucleosomes into the blood circulatory system, and increased levels of circulating nucleosomes have been observed to be related to inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a195be835450e70c0137385b2c5f4544
http://europepmc.org/articles/PMC7505961
http://europepmc.org/articles/PMC7505961
Publikováno v:
Accounts of Chemical Research; 4/5/2022, Vol. 55 Issue 7, p1059-1073, 15p