Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mengru Gu"'
Autor:
Mengru Gu, Hanlu Jiang, Mengzhu Tan, Long Yu, Ning Xu, Ying Li, Han Wu, Qing Hou, Chunsun Dai
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract palmitoylation, a reversible post-translational modification, is initiated by the DHHC family of palmitoyltransferases and reversed by several acyl protein thioesterases. However, the role and mechanisms for protein palmitoylation in renal f
Externí odkaz:
https://doaj.org/article/093e8996f2ad4b94be8d372f694bd7cd
Autor:
Xian Xue, Xingwen Zhu, Lu Zhou, Xiaoli Sun, Mengru Gu, Yan Liang, Mengzhu Tan, Qing Hou, Sudan Wang, Chunsun Dai
Publikováno v:
Kidney Diseases, Pp 1-1 (2024)
Introduction: Transcriptional coactivator with PDZ-binding motif (TAZ), a Hippo signaling pathway effector, maintains the balance of cell proliferation, differentiation, and death. However, the role of TAZ in tubular cell survival and acute kidney in
Externí odkaz:
https://doaj.org/article/433362468658463080c44a3023672490
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-13 (2022)
Abstract The cell-cell interaction between hepatocytes and Kupffer cells (KCs) is crucial for maintaining liver homeostasis, and the loss of KCs and hepatocytes is known to represent a common pathogenic phenomenon in autoimmune hepatitis. Until now,
Externí odkaz:
https://doaj.org/article/a3cb493bd27346d18b81350fad3401fc
Autor:
Qingmiao Lu, Qing Hou, Kai Cao, Xiaoli Sun, Yan Liang, Mengru Gu, Xian Xue, Allan Zijian Zhao, Chunsun Dai
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
The role and mechanisms for upregulating complement factor B (CFB) expression in podocyte dysfunction in diabetic kidney disease (DKD) are not fully understood. Here, analyzing Gene Expression Omnibus GSE30528 data, we identified genes enriched in mT
Externí odkaz:
https://doaj.org/article/668f1ebb575a4890ac22d6837cb8cdd9
Autor:
Lu Zhou, Qingmiao Lu, Sudan Wang, Chunsun Dai, Yan Liang, Qing Hou, Mingjie Wang, Xiaoli Sun, Mengru Gu, Mengzhu Tan, Xian Xue
Publikováno v:
Cell Death and Differentiation
Macrophage accumulation and activation play an essential role in kidney fibrosis; however, the underlying mechanisms remain to be explored. By analyzing the kidney tissues from patients and animal models with kidney fibrosis, we found a large inducti
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
BackgroundDisulfidptosis and ferroptosis are forms of programmed cell death that may be associated with the pathogenesis of periodontitis. Our study developed periodontitis-associated biomarkers combining disulfidptosis and ferroptosis, which provide
Externí odkaz:
https://doaj.org/article/d137075449014250af0bce3692b4c6ca
Autor:
Qing Hou, Mengru Gu, Chunsun Dai, Mingjie Wang, Yuan Gui, Yan Liang, Allan Z. Zhao, Bo Xiao, Qingmiao Lu
Publikováno v:
Cell Death and Disease, Vol 11, Iss 5, Pp 1-14 (2020)
Cell Death & Disease
Cell Death & Disease
Ras homolog enriched in brain (Rheb1), a small GTPase, plays a crucial role in regulating cell growth, differentiation, and survival. However, the role and mechanisms for Rheb1 in tubular cell survival and acute kidney injury (AKI) remain unexplored.
Autor:
Mengru Gu, Xiaoli Sun, Allan Z. Zhao, Chunsun Dai, Xian Xue, Yan Liang, Qing Hou, Kai Cao, Qingmiao Lu
Publikováno v:
JCI Insight
The role and mechanisms for upregulating complement factor B (CFB) expression in podocyte dysfunction in diabetic kidney disease (DKD) are not fully understood. Here, analyzing Gene Expression Omnibus {"type":"entrez-geo","attrs":{"text":"GSE30528","
Autor:
Mengru Gu, Mengzhu Tan, Lu Zhou, Xiaoli Sun, Qingmiao Lu, Mingjie Wang, Hanlu Jiang, Yan Liang, Qing Hou, Xian Xue, Zhuo Xu, Chunsun Dai
Publikováno v:
Kidney international. 102(2)
Energy metabolism is crucial in maintaining cellular homeostasis and adapting to stimuli for tubular cells. However, the underlying mechanisms remain largely unknown. Here, we report that PP2Acα was upregulated in damaged tubular cells from patients
Autor:
Yuan Gui, Xian Xue, Allan Z. Zhao, Mengru Gu, Yan Liang, Bo Xiao, Mingjie Wang, Qingmiao Lu, Xiaoli Sun, Weichun He, Chunsun Dai, Junwei Yang, Xingwen Zhu
Publikováno v:
Cell Death Differ
Kidney fibroblasts play a crucial role in dictating tubular cell fate and the outcome of acute kidney injury (AKI). The underlying mechanisms remain to be determined. Here, we found that mTOR signaling was activated in fibroblasts from mouse kidneys