Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mengrou Shan"'
Autor:
Nneka E. Mbah, Amy L. Myers, Peter Sajjakulnukit, Chan Chung, Joyce K. Thompson, Hanna S. Hong, Heather Giza, Derek Dang, Zeribe C. Nwosu, Mengrou Shan, Stefan R. Sweha, Daniella D. Maydan, Brandon Chen, Li Zhang, Brian Magnuson, Zirui Zhu, Megan Radyk, Brooke Lavoie, Viveka Nand Yadav, Imhoi Koo, Andrew D. Patterson, Daniel R. Wahl, Luigi Franchi, Sameer Agnihotri, Carl J. Koschmann, Sriram Venneti, Costas A. Lyssiotis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract H3K27M diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), exhibit cellular heterogeneity comprising less-differentiated oligodendrocyte precursors (OPC)-like stem cells and more differentiated astrocyte (AC)-l
Externí odkaz:
https://doaj.org/article/b60128e341cf4e8c9deb69669f6c0187
Autor:
Le Tran Phuc Khoa, Wentao Yang, Mengrou Shan, Li Zhang, Fengbiao Mao, Bo Zhou, Qiang Li, Rebecca Malcore, Clair Harris, Lili Zhao, Rajesh C. Rao, Shigeki Iwase, Sundeep Kalantry, Stephanie L. Bielas, Costas A. Lyssiotis, Yali Dou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can enter quiescence spontaneously or upon inhibition of MYC or fatty acid oxidation, mimi
Externí odkaz:
https://doaj.org/article/6b1a1bc377ca40f2bfe4471b19c2237e
Autor:
Le Tran Phuc Khoa, Wentao Yang, Mengrou Shan, Li Zhang, Fengbiao Mao, Bo Zhou, Qiang Li, Rebecca Malcore, Clair Harris, Lili Zhao, Rajesh C. Rao, Shigeki Iwase, Sundeep Kalantry, Stephanie L. Bielas, Costas A. Lyssiotis, Yali Dou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/99c1bf8c94c5449d90874ae8fbf5c9e4
Autor:
Julia A. Brown, Katherine Z. Sanidad, Serena Lucotti, Carolin M. Lieber, Robert M. Cox, Aparna Ananthanarayanan, Srijani Basu, Justin Chen, Mengrou Shan, Mohammed Amir, Fabian Schmidt, Yiska Weisblum, Michele Cioffi, Tingting Li, Florencia Madorsky Rowdo, M. Laura Martin, Chun-Jun Guo, Costas A. Lyssiotis, Brian T. Layden, Andrew J. Dannenberg, Paul D. Bieniasz, Benhur Lee, Naohiro Inohara, Irina Matei, Richard K. Plemper, Melody Y. Zeng
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
The gut microbiome is intricately coupled with immune regulation and metabolism, but its role in Coronavirus Disease 2019 (COVID-19) is not fully understood. Severe and fatal COVID-19 is characterized by poor anti-viral immunity and hypercoagulation,
Externí odkaz:
https://doaj.org/article/af4ba1f980974ee5b64d7229b89889c3
Autor:
Daniel M. Kremer, Barbara S. Nelson, Lin Lin, Emily L. Yarosz, Christopher J. Halbrook, Samuel A. Kerk, Peter Sajjakulnukit, Amy Myers, Galloway Thurston, Sean W. Hou, Eileen S. Carpenter, Anthony C. Andren, Zeribe C. Nwosu, Nicholas Cusmano, Stephanie Wisner, Nneka E. Mbah, Mengrou Shan, Nupur K. Das, Brian Magnuson, Andrew C. Little, Milan R. Savani, Johanna Ramos, Tina Gao, Stephen A. Sastra, Carmine F. Palermo, Michael A. Badgley, Li Zhang, John M. Asara, Samuel K. McBrayer, Marina Pasca di Magliano, Howard C. Crawford, Yatrik M. Shah, Kenneth P. Olive, Costas A. Lyssiotis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The aspartate aminotransaminase GOT1 is important for maintaining redox balance. Here, the authors show that inhibition of GOT1 in pancreatic cancer cells leads to cell death via ferroptosis.
Externí odkaz:
https://doaj.org/article/ed8c3b2903a54147ade49ed6c779e8e5
Autor:
Carmen Mirabelli, Melissa K. Jones, Vivienne L. Young, Abimbola O. Kolawole, Irene Owusu, Mengrou Shan, Basel Abuaita, Holly Turula, Jose G. Trevino, Irina Grigorova, Steven K. Lundy, Costas A. Lyssiotis, Vernon K. Ward, Stephanie M. Karst, Christiane E. Wobus
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Human norovirus (HNoV) is a global health and socioeconomic burden, estimated to infect every individual at least five times during their lifetime. The underlying mechanism for the potential lack of long-term immune protection from HNoV infe
Externí odkaz:
https://doaj.org/article/298a2a3779044a91988f0db58af882d8
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 12, p e1006584 (2018)
Cancer metabolism has received renewed interest as a potential target for cancer therapy. In this study, we use a multi-scale modeling approach to interrogate the implications of three metabolic scenarios of potential clinical relevance: the Warburg
Externí odkaz:
https://doaj.org/article/ea5a3d7667184632a525c3ca8c41ae2e
Autor:
Giulio F. Draetta, Andrea Viale, Costas A. Lyssiotis, Pier Paolo Scaglioni, Giannicola Genovese, Angela K. Deem, Sisi Gao, Li Zhang, Maureen Kachman, Zachary P. Tolstyka, Mengrou Shan, Lin Tan, Philip L. Lorenzi, Erik P. Sulman, Frederick F. Lang, Sanjana Srinivasan, Sahil Seth, Pushan Dasgupta, Joy Gumin, Edoardo Del Poggetto, Federica Carbone, Ciro Zanca, Jintan Liu, Emmet Huang-Hobbs, Alessandro Carugo, Piergiorgio Pettazzoni, Caterina Bartolacci, Fei Yu, Francesca Puca
Glioblastoma (GBM) is highly resistant to chemotherapies, immune-based therapies, and targeted inhibitors. To identify novel drug targets, we screened orthotopically implanted, patient-derived glioblastoma sphere-forming cells using an RNAi library t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9012680724c9c88367f5f9bb3ac0bf34
https://doi.org/10.1158/2159-8290.c.6549482.v1
https://doi.org/10.1158/2159-8290.c.6549482.v1
Autor:
Giulio F. Draetta, Andrea Viale, Costas A. Lyssiotis, Pier Paolo Scaglioni, Giannicola Genovese, Angela K. Deem, Sisi Gao, Li Zhang, Maureen Kachman, Zachary P. Tolstyka, Mengrou Shan, Lin Tan, Philip L. Lorenzi, Erik P. Sulman, Frederick F. Lang, Sanjana Srinivasan, Sahil Seth, Pushan Dasgupta, Joy Gumin, Edoardo Del Poggetto, Federica Carbone, Ciro Zanca, Jintan Liu, Emmet Huang-Hobbs, Alessandro Carugo, Piergiorgio Pettazzoni, Caterina Bartolacci, Fei Yu, Francesca Puca
Supplementary Figures S1 through S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426c9b71c727512490f2493fee2b2d53
https://doi.org/10.1158/2159-8290.22540823
https://doi.org/10.1158/2159-8290.22540823
Autor:
Hanna S. Hong, Nneka E. Mbah, Mengrou Shan, Kristen Loesel, Lin Lin, Peter Sajjakulnukit, Luis O. Correa, Anthony Andren, Jason Lin, Atsushi Hayashi, Brian Magnuson, Judy Chen, Zhaoheng Li, Yuying Xie, Li Zhang, Daniel R. Goldstein, Shannon A. Carty, Yu Leo Lei, Anthony W. Opipari, Rafael J. Argüello, Ilona Kryczek, Nobuhiko Kamada, Weiping Zou, Luigi Franchi, Costas A. Lyssiotis
Publikováno v:
Science Immunology
Science Immunology, 2023, 7, ⟨10.1126/sciimmunol.abm8182⟩
Sci Immunol
Science Immunology, 2023, 7, ⟨10.1126/sciimmunol.abm8182⟩
Sci Immunol
T cell proliferation and cytokine production are bioenergetically and biosynthetically costly. The inability to meet these metabolic demands results in altered differentiation, accompanied by impaired effector function, and attrition of the immune re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a05d4a9e1c147f75d230beb3ade971
https://hal-amu.archives-ouvertes.fr/hal-04062465/file/nihms-1861567.pdf
https://hal-amu.archives-ouvertes.fr/hal-04062465/file/nihms-1861567.pdf