Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Mengle Shao"'
Autor:
Tao Yao, Danni Wei, Xin Tian, Lin Zhao, Qiangyou Wan, Xiaoli Zhang, Juan Cai, Siqi Li, Bowen Diao, Suihan Feng, Bo Shan, Mengle Shao, Ying Wu
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Background Obesity is associated with extensive white adipose tissue (WAT) expansion and remodeling. Healthy WAT expansion contributes to the maintenance of energy balance in the liver, thereby ameliorating obesity-related hepatic steatosis.
Externí odkaz:
https://doaj.org/article/101d1b27d2e84cf2b265bc58cebb3299
Autor:
Yuhui Fu, Binbin Ding, Xiaoxia Liu, Shangang Zhao, Fang Chen, Linsen Li, Yi Zhu, Jingxuan Zhao, Zhen Yuan, Yafeng Shen, Chaofeng Yang, Mengle Shao, She Chen, Perry E. Bickel, Qing Zhong
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-22 (2023)
Abstract Lipid droplets (LDs) are dynamic lipid storage organelles that can sense and respond to changes in systemic energy balance. The size and number of LDs are controlled by complex and delicate mechanisms, among which, whether and which SNARE pr
Externí odkaz:
https://doaj.org/article/d73b0f5e6c844c74ad725a1cd344b84d
Publikováno v:
Endocrinology and Metabolism, Vol 38, Iss 5, Pp 493-503 (2023)
The growing recognition of mitochondria’s crucial role in the regulation of white adipose tissue remodeling and energy balance underscores its significance. The marked metabolic diversity of mitochondria provides the molecular and cellular foundati
Externí odkaz:
https://doaj.org/article/cbaad73162764955b0e8e701738b9dd3
Autor:
Bo Shan, Clive S. Barker, Harry Theraulaz, Xiaoli Zhang, Yan Ping, Rana K. Gupta, Mengle Shao, Yibo Wu
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102676- (2023)
Summary: Recent studies have revealed cellular heterogeneity of mesenchymal stromal cells and immune cells in adipose tissue and emphasized the need for quantitative analysis of small numbers of functionally distinct cells using state-of-the-art “o
Externí odkaz:
https://doaj.org/article/a3730abcae3b4d8e9b02b51dd61b2d63
Autor:
Shengnan Liu, Siyi Shen, Ying Yan, Chao Sun, Zhiqiang Lu, Hua Feng, Yiruo Ma, Zhili Tang, Jing Yu, Yuting Wu, Balázs Gereben, Petra Mohácsik, Csaba Fekete, Xiaoyun Feng, Feixiang Yuan, Feifan Guo, Cheng Hu, Mengle Shao, Xin Gao, Lin Zhao, Yuying Li, Jingjing Jiang, Hao Ying
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Thyroid hormone (TH) action regulates brown adipose tissue thermogenic capacity through incompletely understood mechanisms. Here the authors report that T3, the active form of TH, increases thermogenic capacity via thyroid hormone receptor α-mediate
Externí odkaz:
https://doaj.org/article/139a7b09a0524209a9dd013c322aac09
Autor:
Yunlin Ge, Siqi Li, Tao Yao, Yuexiao Tang, Qiangyou Wan, Xiaoli Zhang, Jing Zhao, Mingliang Zhang, Mengle Shao, Lijun Wang, Ying Wu
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
A large subset of elders is classified as having sarcopenic obesity, a prevalence of obesity in combination with sarcopenia which places an aging population at the risk of adverse health consequences from both conditions. However, its complex etiolog
Externí odkaz:
https://doaj.org/article/8f39cc4d94a143d38c56fe4d2b27fc43
Autor:
Camila O. de Souza, Vivian A. Paschoal, Xuenan Sun, Lavanya Vishvanath, Qianbin Zhang, Mengle Shao, Toshiharu Onodera, Shiuhwei Chen, Nolwenn Joffin, Lorena M.A. Bueno, Rana K. Gupta, Da Young Oh
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
The molecular mechanisms underlying obesity-induced increases in β cell mass and the resulting β cell dysfunction need to be elucidated further. Our study revealed that GPR92, expressed in islet macrophages, is modulated by dietary interventions in
Externí odkaz:
https://doaj.org/article/fad1f9602d634304975cb07c353a06b4
Autor:
Yi Zhu, Na Li, Mingyang Huang, Mason Bartels, Sophie Dogné, Shangang Zhao, Xi Chen, Clair Crewe, Leon Straub, Lavanya Vishvanath, Zhuzhen Zhang, Mengle Shao, Yongjie Yang, Christy M. Gliniak, Ruth Gordillo, Gordon I. Smith, William L. Holland, Rana K. Gupta, Bingning Dong, Nathalie Caron, Yong Xu, Yucel Akgul, Samuel Klein, Philipp E. Scherer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Hyaluronan is a naturally occurring linear polysaccharide that together with collagens, enzymes, and glycoproteins forms the extracellular matrix. Here the authors show that adipose tissue overproduction of Hyaluronan reduces fat accumulation in mice
Externí odkaz:
https://doaj.org/article/d5d6f30432264ee3a4a2783133e16a29
Autor:
Yingfeng Deng, Zhao V. Wang, Ruth Gordillo, Yi Zhu, Aktar Ali, Chen Zhang, Xiaoding Wang, Mengle Shao, Zhuzhen Zhang, Puneeth Iyengar, Rana K. Gupta, Jay D. Horton, Joseph A. Hill, Philipp E. Scherer
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 1-17 (2018)
Objective: The spliced transcription factor Xbp1 (Xbp1s), a transducer of the unfolded protein response (UPR), regulates lipolysis. Lipolysis is stimulated by fasting when uridine synthesis is also activated in adipocytes. Methods: Here we have exami
Externí odkaz:
https://doaj.org/article/b2b47e6a4e904925aa53b722a829c482
Autor:
Mengle Shao, Lavanya Vishvanath, Napoleon C. Busbuso, Chelsea Hepler, Bo Shan, Ankit X. Sharma, Shiuhwei Chen, Xinxin Yu, Yu A. An, Yi Zhu, William L. Holland, Rana K. Gupta
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Adipocyte hyperplasia is thought to have beneficial metabolic effects in obesity, but definitive evidence is lacking. Here, Shao et al. promote de novo formation of adipocytes in visceral white adipose tissue (WAT) of adult mice through inducible ove
Externí odkaz:
https://doaj.org/article/6cc640ee069d48bba9a616e022b49eb9