Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Mengke Niu"'
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-48 (2024)
Abstract Cytokines are critical in regulating immune responses and cellular behavior, playing dual roles in both normal physiology and the pathology of diseases such as cancer. These molecules, including interleukins, interferons, tumor necrosis fact
Externí odkaz:
https://doaj.org/article/a55d889783594e3f8f5e2cd5852e0f8f
Publikováno v:
Cancer Communications, Vol 44, Iss 7, Pp 739-760 (2024)
Abstract Immunotherapy, particularly with immune checkpoint inhibitors, has significantly transformed cancer treatment. Despite its success, many patients struggle to respond adequately or sustain long‐lasting clinical improvement. A growing consen
Externí odkaz:
https://doaj.org/article/85912ae7e92543419e0557cbeeca5c02
Publikováno v:
Nuclear Materials and Energy, Vol 40, Iss , Pp 101728- (2024)
In recent years, medium and/or high-entropy alloys (M/HEAs) have attracted attention due to their excellent mechanical properties, positioning them as potential candidates for structural materials in advanced nuclear reactors. This study investigated
Externí odkaz:
https://doaj.org/article/af8ff74361c24c2189ac12e88a4ed062
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract The programmed cell death 1 (PD-1) signaling pathway, a key player in immune checkpoint regulation, has become a focal point in cancer immunotherapy. In the context of cancer, upregulated PD-L1 on tumor cells can result in T cell exhaustion
Externí odkaz:
https://doaj.org/article/c9b496fd3bf840cc94a348cdb1a67900
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-18 (2023)
Abstract Background S100A8 and S100A9 are members of Ca2+-binding EF-hand superfamily, mainly expressed by macrophages and neutrophils. Limited by the poor stability of homodimers, they commonly exist as heterodimers. Beyond acting as antibacterial c
Externí odkaz:
https://doaj.org/article/5f7eb95826cc47ed9db134cb2c9a90be
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-55 (2023)
Abstract Immunotherapies have revolutionized the treatment paradigms of various types of cancers. However, most of these immunomodulatory strategies focus on harnessing adaptive immunity, mainly by inhibiting immunosuppressive signaling with immune c
Externí odkaz:
https://doaj.org/article/2511b2e1dbb841e1a6a4f281545a4c1e
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundCervical cancer poses a significant global threat to women’s health. However, current therapeutic interventions, such as radiotherapy, chemotherapy, surgical resection, and immune checkpoint inhibitors, face limitations in the advanced st
Externí odkaz:
https://doaj.org/article/50e7020d2c324da39a13b66a8d3305a3
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Natural Killer (NK) cells, intrinsic to the innate immune system, are pivotal in combating cancer due to their independent cytotoxic capabilities in antitumor immune response. Unlike predominant treatments that target T cell immunity, the limited suc
Externí odkaz:
https://doaj.org/article/37273c8438f041e1abad84fea04bdf4e
Autor:
Mengke Niu, Ming Yi, Yuze Wu, Lijuan Lyu, Qing He, Rui Yang, Liang Zeng, Jian Shi, Jing Zhang, Pengfei Zhou, Tingting Zhang, Qi Mei, Qian Chu, Kongming Wu
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-23 (2023)
Abstract Background Recently, therapeutic antibodies against programmed cell death 1 (PD-1) and its ligand (PD-L1) have exerted potent anticancer effect in a variety of tumors. However, blocking the PD-1/PD-L1 axis alone is not sufficient to restore
Externí odkaz:
https://doaj.org/article/35bf10f2eb9c4508a57429cc15f28a56
Publikováno v:
Nuclear Materials and Energy, Vol 37, Iss , Pp 101556- (2023)
FeCrAl ODS steel is the promising candidate cladding material for the accident tolerant fuel (ATF) of the light water reactors (LWR), due to the formation of Al2O3 in alloys which could suppress the oxidation reaction with hot steam. In the present w
Externí odkaz:
https://doaj.org/article/6e733fadb0504faeb85c5495466f68a4