Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Mengke CHEN"'
Autor:
Xueting Wang, Lu Liu, Mengke Chen, Yun Quan, Jiaxin Zhang, Huiqiang Lou, Yisui Xia, Hongxiang Chen, Wenya Hou
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Mcm10 plays an essential role in the activation of replicative helicase CMG through the cell cycle-regulated interaction with the prototype MCM double hexamer in Saccharomyces cerevisiae. In this study, we reported that Mcm10 is phosphorylated by S-p
Externí odkaz:
https://doaj.org/article/365e52eafe1744af8e013d2746b815ee
Autor:
Yulu Chen, Ye Sang, Shiyong Li, Junyu Xue, Mengke Chen, Shubin Hong, Weiming Lv, Kartik Sehgal, Haipeng Xiao, Rengyun Liu
Publikováno v:
Translational Oncology, Vol 45, Iss , Pp 101991- (2024)
BRAF or RAS mutation-induced aberrant activation of the mitogen-activated protein kinase (MAPK) pathway is frequently observed in human cancers. As the key downstream node of MAPK pathway, ERK1/2 is as an important therapeutic target. GDC-0994 (ravox
Externí odkaz:
https://doaj.org/article/a06cafe2d8e1449ead38b4f0a66de4de
Autor:
Yunqiao Zhou, Xiaoping Wang, Mengke Chen, Jianjie Fu, Tingting Zhu, Chuanfei Wang, Ping Gong, Lanxiang Wang, Jiao Ren
Publikováno v:
Communications Earth & Environment, Vol 5, Iss 1, Pp 1-11 (2024)
Abstract How climate change will influence the accumulation of pollutants in remote mountainous lakes is poorly understood. Here we collected sediment cores from two glacial lakes (one is small and close to glacier, and the other is large and far fro
Externí odkaz:
https://doaj.org/article/4787ff3c752a4dacb2353c53dc88376a
Autor:
Yongjun Liu, Yuqing Xu, Xiaoxing Li, Mengke Chen, Xueqin Wang, Ning Zhang, Heping Zhang, Zhengjun Zhang
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract The goal of this study was to use a new interpretable machine-learning framework based on max-logistic competing risk factor models to identify a parsimonious set of differentially expressed genes (DEGs) that play a pivotal role in the devel
Externí odkaz:
https://doaj.org/article/078d3f8d2c1c4d429d38596b8f6484c1
Autor:
Qin Tang, Guanghui Hu, Ye Sang, Yulu Chen, Guangyan Wei, Meiyan Zhu, Mengke Chen, Shiyong Li, Rengyun Liu, Zhenwei Peng
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 5, Pp n/a-n/a (2024)
Abstract Background Hotspot mutations in the promoter of telomerase reverse transcriptase (TERT) gene are the most common genetic variants in hepatocellular carcinoma (HCC) and associated with poor prognosis of the disease. However, no drug was curre
Externí odkaz:
https://doaj.org/article/70872f9b1ffa48a7bbc1407a22f3f09e
Autor:
Fengjiao Pan, Ruixiao Zhang, Xuyan Liu, Xiaomeng Shi, Qing Xin, Dan Qiao, Changying Li, Yan Zhang, Mengke Chen, Wencong Guo, Shufang Luan, Leping Shao
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Background: X-linked hypophosphatemia (XLH, OMIM 307800) is a rare phosphorus metabolism disorder caused by PHEX gene variants. Many variants simply classified as missense or nonsense variants were only analyzed at the DNA level. However, growing evi
Externí odkaz:
https://doaj.org/article/645763076f2b49b2a0327a68bc254522
Autor:
Weiwen Shi, Mengke Chen, Tingting Pan, Mengjie Chen, Yongjun Cheng, Yimei Hao, Sheng Chen, Yuanjia Tang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The role of host genetic factors in COVID-19 outcomes remains unclear despite various genome-wide association studies (GWAS). We annotate all significant variants and those variants in high LD (R2 > 0.8) from the COVID-19 host genetics initi
Externí odkaz:
https://doaj.org/article/56ca75da8d514d7ba9400faaa0fd9ebe
Autor:
Xuyan Liu, Xiaomeng Shi, Qing Xin, Zhiying Liu, Fengjiao Pan, Dan Qiao, Mengke Chen, Yiyin Zhang, Wencong Guo, Changying Li, Yan Zhang, Leping Shao, Ruixiao Zhang
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic multisystem disease caused primarily by mutations in the PKD1 gene or PKD2 gene. There is increasing evidence that some of these variants, which are descri
Externí odkaz:
https://doaj.org/article/f5715f55bb2b42f5894b66d609e557c4
Autor:
Mengke Chen, Yi Fang, Meinong Liang, Ning Zhang, Xinyue Zhang, Lixia Xu, Xuxin Ren, Qingfeng Zhang, Yufeng Zhou, Sui Peng, Jun Yu, Judeng Zeng, Xiaoxing Li
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Both dysregulation of mechanistic target of rapamycin (mTOR) signalling and DNA methylation patterns have been shown to be closely associated with tumor progression and serve as promising targets for hepatocellular carcinoma (HCC)
Externí odkaz:
https://doaj.org/article/6b7fdee91e614b1088a79007fc3316f9
Autor:
Mengke Chen, Junyu Xue, Ye Sang, Wenting Jiang, Weiman He, Shubin Hong, Weiming Lv, Haipeng Xiao, Rengyun Liu
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background Thyroid cancer is the most frequent malignancy of the endocrine system, of which papillary thyroid cancer (PTC) is the predominant form with a rapid increasing incidence worldwide. Rearranged during transfection (RET) fusions are
Externí odkaz:
https://doaj.org/article/d679a23b0db241c29457eb68e599f432