Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Menghan Du"'
Autor:
Patricia A. Clow, Menghan Du, Nathaniel Jillette, Aziz Taghbalout, Jacqueline J. Zhu, Albert W. Cheng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Three-dimensional (3D) structures of the genome are dynamic, heterogeneous and functionally important. Here the authors present a CRISPR-based approach for labeling the genome at multiple nonrepetitive loci in living cells and to image chromatin loop
Externí odkaz:
https://doaj.org/article/e739a9d4c7614d4c8e8421cc2d63189e
Autor:
Yingying Hu, Shuqian Zhang, Han Lou, Monayo Seth Mikaye, Run Xu, Ziyu Meng, Menghan Du, Pingping Tang, Zhouxiu Chen, Yongchao Chen, Xin Liu, Zhimin Du, Yong Zhang
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1275 (2023)
Diabetic cardiomyopathy (DCM) is widely recognized as a major contributing factor to the development of heart failure in patients with diabetes. Previous studies have demonstrated the potential benefits of traditional herbal medicine for alleviating
Externí odkaz:
https://doaj.org/article/2f79b5e4eb4e4bd1ad87382fb889fbd6
Publikováno v:
Mathematics, Vol 11, Iss 15, p 3376 (2023)
In this paper, we consider stochastic mixed vector variational inequality problems. Firstly, we present an equivalent form for the stochastic mixed vector variational inequality problems. Secondly, we present a deterministic bi-criteria model for giv
Externí odkaz:
https://doaj.org/article/e767f81eeb6d44de927aeaea87323ba9
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Control over splicing could be used for both therapeutic and engineering applications. Here the authors create artificial splicing factors using RNA-targeting CRISPR systems under small molecule control.
Externí odkaz:
https://doaj.org/article/fa264e04819c4745a7fbdb519bfa799a
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Selectable markers are widely used in cell engineering but there is only a limited variety to choose from. Here the authors split markers using inteins, allowing up to six transgene integration events to be selected for with one marker.
Externí odkaz:
https://doaj.org/article/c526fa456318455daf9b51a1e8c0784b
Autor:
Aziz Taghbalout, Menghan Du, Nathaniel Jillette, Wojciech Rosikiewicz, Abhijit Rath, Christopher D. Heinen, Sheng Li, Albert W. Cheng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
DNA methylation plays an important role in regulating a wide variety of cellular processes and is implicated in a range of diseases. Here the authors present Casilio-ME to assemble protein complexes to demethylate target loci.
Externí odkaz:
https://doaj.org/article/6bfa03502fb24550a614110069d7480f
Autor:
Abhijit Rath, Christopher D. Heinen, Nathaniel Jillette, Aziz Taghbalout, Wojciech Rosikiewicz, Albert W. Cheng, Menghan Du, Sheng Li
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Here we develop a methylation editing toolbox, Casilio-ME, that enables not only RNA-guided methylcytosine editing by targeting TET1 to genomic sites, but also by co-delivering TET1 and protein factors that couple methylcytosine oxidation to DNA repa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf4f8f65468435755e8e34e31fa32fc
https://doaj.org/article/6bfa03502fb24550a614110069d7480f
https://doaj.org/article/6bfa03502fb24550a614110069d7480f
Autor:
Alphons J.M. Vermorken, Mingwei Chen, Qian Liu, Qinlu Zhang, Menghan Du, Lixia Zhang, Yali Cui, Lili Guo, Le Ma
Publikováno v:
Journal of Magnetism and Magnetic Materials. 481:122-128
Non-small cell lung cancer (NSCLC) accounts for 80–85% of all lung cancer which is the leading cause of cancer death worldwide. Eighty percent of NSCLC patients exhibit high levels of epidermal growth factor receptor (EGFR) expression. In recent ye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9758af620c63a4cc4ff22b512185aeeb
https://doi.org/10.1016/j.jmmm.2019.01.021
https://doi.org/10.1016/j.jmmm.2019.01.021
Autor:
Patricia A. Clow, Menghan Du, Nathaniel Jillette, Aziz Taghbalout, Jacqueline J. Zhu, Albert W. Cheng
Three-dimensional (3D) structures of the genome are dynamic, heterogeneous and functionally important. Live cell imaging has become the leading method for chromatin dynamics tracking. However, existing CRISPR- and TALE-based genomic labeling techniqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e4f040663b8103b84ab5e75e77518a
https://doi.org/10.1101/2020.03.03.974923
https://doi.org/10.1101/2020.03.03.974923
Selectable markers are widely adopted in transgenesis and genome editing for selecting engineered cells with desired genotype but are limited in choices. We present here split selectable markers each allowing for selection of multiple “unlinked”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c800cb75f2c3519e1225b78d48754e0
https://doi.org/10.1101/452979
https://doi.org/10.1101/452979