Zobrazeno 1 - 10
of 306
pro vyhledávání: '"Menggang Yu"'
Autor:
Nicholas R. Rydzewski, Yue Shi, Chenxuan Li, Matthew R. Chrostek, Hamza Bakhtiar, Kyle T. Helzer, Matthew L. Bootsma, Tracy J. Berg, Paul M. Harari, John M. Floberg, Grace C. Blitzer, David Kosoff, Amy K. Taylor, Marina N. Sharifi, Menggang Yu, Joshua M. Lang, Krishnan R. Patel, Deborah E. Citrin, Kaitlin E. Sundling, Shuang G. Zhao
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Histopathologic diagnosis and classification of cancer plays a critical role in guiding treatment. Advances in next-generation sequencing have ushered in new complementary molecular frameworks. However, existing approaches do not independent
Externí odkaz:
https://doaj.org/article/27df8447126a4b8db5d9d92bb0d0f133
Autor:
Hamza Bakhtiar, Kyle T. Helzer, Yeonhee Park, Yi Chen, Nicholas R. Rydzewski, Matthew L. Bootsma, Yue Shi, Paul M. Harari, Marina Sharifi, Martin Sjöström, Joshua M. Lang, Menggang Yu, Shuang G. Zhao
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract DNA mutations in specific genes can confer preferential benefit from drugs targeting those genes. However, other molecular perturbations can “phenocopy” pathogenic mutations, but would not be identified using standard clinical sequencing
Externí odkaz:
https://doaj.org/article/e2291cadffc94043a32301fcbd5da0f7
Autor:
Taja Lozar, Israa Laklouk, Athena E. Golfinos, Niki Gavrielatou, Jin Xu, Christopher Flynn, Aysenur Keske, Menggang Yu, Justine Y. Bruce, Wei Wang, Cvetka Grasic Kuhar, Howard H. Bailey, Paul M. Harari, Huy Q. Dinh, David L. Rimm, Rong Hu, Paul F. Lambert, Megan B. Fitzpatrick
Publikováno v:
Cancers, Vol 15, Iss 19, p 4905 (2023)
Low response rates in immune check-point blockade (ICB)-treated head and neck squamous cell carcinoma (HNSCC) drive a critical need for robust, clinically validated predictive biomarkers. Our group previously showed that stress keratin 17 (CK17) supp
Externí odkaz:
https://doaj.org/article/5c15423f7eb347d0a60f6ff2e7942a5f
Publikováno v:
BMC Medical Research Methodology, Vol 22, Iss 1, Pp 1-7 (2022)
Abstract Background The exchange of knowledge between statisticians developing new methodology and clinicians, reviewers or authors applying them is fundamental. This is specifically true for clinical trials with time-to-event endpoints. Thereby, one
Externí odkaz:
https://doaj.org/article/231bf7d3da304d6789db16a6cedc2f32
Autor:
Yingzhou Liu, Menggang Yu, Jamie N LaMantia, Jennifer Mason Lobo, Justin J Boutilier, Yao Liu, Meghan B Brennan
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0294813 (2023)
ObjectiveSpecialty care may improve diabetic foot ulcer outcomes. Medically underserved populations receive less specialty care. We aimed to determine the association between specialty care and ulcer progression, major amputation, or death. If a bene
Externí odkaz:
https://doaj.org/article/11cdf7c35bb24015a280be632f129f66
Autor:
Shuang G. Zhao, Jamie M. Sperger, Jennifer L. Schehr, Rana R. McKay, Hamid Emamekhoo, Anupama Singh, Zachery D. Schultz, Rory M. Bade, Charlotte N. Stahlfeld, Cole S. Gilsdorf, Camila I. Hernandez, Serena K. Wolfe, Richel D. Mayberry, Hannah M. Krause, Matt Bootsma, Kyle T. Helzer, Nicholas Rydzewski, Hamza Bakhtiar, Yue Shi, Grace Blitzer, Christos E. Kyriakopoulos, David Kosoff, Xiao X. Wei, John Floberg, Nan Sethakorn, Marina Sharifi, Paul M. Harari, Wei Huang, Himisha Beltran, Toni K. Choueiri, Howard I. Scher, Dana E. Rathkopf, Susan Halabi, Andrew J. Armstrong, David J. Beebe, Menggang Yu, Kaitlin E. Sundling, Mary-Ellen Taplin, Joshua M. Lang
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
Background Neuroendocrine prostate cancer (NEPC) is an aggressive subtype, the presence of which changes the prognosis and management of metastatic prostate cancer.Methods We performed analytical validation of a Circulating Tumor Cell (CTC) multiplex
Externí odkaz:
https://doaj.org/article/ec5e2f5145314e94b0c25808c0d5eee0
Autor:
Nicholas R. Rydzewski, Erik Peterson, Joshua M. Lang, Menggang Yu, S. Laura Chang, Martin Sjöström, Hamza Bakhtiar, Gefei Song, Kyle T. Helzer, Matthew L. Bootsma, William S. Chen, Raunak M. Shrestha, Meng Zhang, David A. Quigley, Rahul Aggarwal, Eric J. Small, Daniel R. Wahl, Felix Y. Feng, Shuang G. Zhao
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract We are now in an era of molecular medicine, where specific DNA alterations can be used to identify patients who will respond to specific drugs. However, there are only a handful of clinically used predictive biomarkers in oncology. Herein, w
Externí odkaz:
https://doaj.org/article/683460200e2546bd8518fb156fad7efa
Publikováno v:
Journal of Medical Internet Research, Vol 24, Iss 6, p e29420 (2022)
BackgroundImpactability modeling promises to help solve the nationwide crisis in caring for high-need high-cost patients by matching specific case management programs with patients using a “benefit” or “impactability” score, but there are lim
Externí odkaz:
https://doaj.org/article/75d7f846e69646f6bde76f42cfbfd56f
Publikováno v:
Statistical Theory and Related Fields, Vol 4, Iss 2, Pp 202-213 (2020)
Quantile treatment effects can be important causal estimands in evaluation of biomedical treatments or interventions for health outcomes such as medical cost and utilisation. We consider their estimation in observational studies with many possible co
Externí odkaz:
https://doaj.org/article/6fb433d3a968464fadcf5167cbf064a6
Autor:
Michael C Fiore, Stevens S Smith, Robert T Adsit, Daniel M Bolt, Karen L Conner, Steven L Bernstein, Oliver D Eng, David Lazuk, Alec Gonzalez, Douglas E Jorenby, Heather D'Angelo, Julie A Kirsch, Brian Williams, Margaret B Nolan, Todd Hayes-Birchler, Sean Kent, Hanna Kim, Thomas M Piasecki, Wendy S Slutske, Stan Lubanski, Menggang Yu, Youmi Suk, Yuxin Cai, Nitu Kashyap, Jomol P Mathew, Gabriel McMahan, Betsy Rolland, Hilary A Tindle, Graham W Warren, Lawrence C An, Andrew D Boyd, Darlene H Brunzell, Victor Carrillo, Li-Shiun Chen, James M Davis, Deepika Dilip, Edward F Ellerbeck, Eduardo Iturrate, Thulasee Jose, Niharika Khanna, Andrea King, Elizabeth Klass, Michael Newman, Kimberly A Shoenbill, Elisa Tong, Janice Y Tsoh, Karen M Wilson, Wendy E Theobald, Timothy B Baker
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274571 (2022)
Main objectiveThere is limited information on how patient outcomes have changed during the COVID-19 pandemic. This study characterizes changes in mortality, intubation, and ICU admission rates during the first 20 months of the pandemic.Study design a
Externí odkaz:
https://doaj.org/article/f04f7458f5a34700b43c44ba4f5d21c3