Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Mengfan Tang"'
Autor:
Litong Nie, Chao Wang, Min Huang, Xiaoguang Liu, Xu Feng, Mengfan Tang, Siting Li, Qinglei Hang, Hongqi Teng, Xi Shen, Li Ma, Boyi Gan, Junjie Chen
Publikováno v:
eLife, Vol 12 (2024)
Poly(ADP-ribose)ylation or PARylation by PAR polymerase 1 (PARP1) and dePARylation by poly(ADP-ribose) glycohydrolase (PARG) are equally important for the dynamic regulation of DNA damage response. PARG, the most active dePARylation enzyme, is recrui
Externí odkaz:
https://doaj.org/article/92e85ce7326f405eb84500e2b50e7d5b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16325 (2023)
The Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system, an RNA-based adaptive immune system found in bacteria and archaea, has catalyzed the development and application of a new generation of ge
Externí odkaz:
https://doaj.org/article/6d21b416e4914ff589d0de323cc92687
Autor:
Huimin Zhang, Yun Xiong, Dan Su, Chao Wang, Mrinal Srivastava, Mengfan Tang, Xu Feng, Min Huang, Zhen Chen, Junjie Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Here the authors find that MUS81 mediates excess DNA double strand break (DSB) generation in TDP1 KO cells after camptothecin treatment. They show that TOP1 cleavage complexes can be either resolved directly by TDP1 or be converted into DSBs and repa
Externí odkaz:
https://doaj.org/article/2f17fbf33b5f4af8b6a6dada3fa18f7b
Autor:
Jeong-Min Park, Huimin Zhang, Litong Nie, Chao Wang, Min Huang, Xu Feng, Mengfan Tang, Zhen Chen, Yun Xiong, Namsoo Lee, Siting Li, Ling Yin, Traver Hart, Junjie Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6545 (2023)
Etoposide (ETO) is an anticancer drug that targets topoisomerase II (TOP2). It stabilizes a normally transient TOP2–DNA covalent complex (TOP2cc), thus leading to DNA double-strand breaks (DSBs). Tyrosyl-DNA phosphodiesterases two (TDP2) is directl
Externí odkaz:
https://doaj.org/article/6c3609d1e8ed4e23bcc0a7e89023a8de
Publikováno v:
Applied Sciences, Vol 12, Iss 15, p 7546 (2022)
Malware detection is of great significance for maintaining the security of information systems. Malware obfuscation techniques and malware variants are increasingly emerging, but their samples and API (application programming interface) sequences are
Externí odkaz:
https://doaj.org/article/455424653c1d48c89be62d7ba2fec0bb
Autor:
Zhen Chen, Caoqi Lei, Chao Wang, Nan Li, Mrinal Srivastava, Mengfan Tang, Huimin Zhang, Jong Min Choi, Sung Yun Jung, Jun Qin, Junjie Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
AMPK is regulates cellular energy and has been extensively studied, although our knowledge of downstream substrates is incomplete. Here, Chen et al. perform global quantitative analysis for AMPK-dependent sites and validate one hit, ARMC10, as a dire
Externí odkaz:
https://doaj.org/article/c4d35187bada4634b09ee0cf3c4b49b5
Autor:
Mengfan Tang, Xu Feng, Guangsheng Pei, Mrinal Srivastava, Chao Wang, Zhen Chen, Siting Li, Huimin Zhang, Zhongming Zhao, Xu Li, Junjie Chen
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108018- (2020)
Summary: 53BP1 plays a central role in dictating DNA repair choice between non-homologous end joining (NHEJ) and homologous recombination (HR), which is important for the sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis) of BRCA1-deficie
Externí odkaz:
https://doaj.org/article/a978b774e9f94622979bc3e3541acc73
Autor:
Mrinal Srivastava, Zhen Chen, Huimin Zhang, Mengfan Tang, Chao Wang, Sung Yun Jung, Junjie Chen
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3869-3883.e4 (2018)
Summary: Eukaryotic cells use copious measures to ensure accurate duplication of the genome. Various genotoxic agents pose threats to the ongoing replication fork that, if not efficiently dealt with, can result in replication fork collapse. It is unk
Externí odkaz:
https://doaj.org/article/df1f95fdd6e245e29bf2e80f3da864c4
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/2204e074cb444f7d8a7d21814726f804
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82146 (2013)
Learning gene expression programs directly from a set of observations is challenging due to the complexity of gene regulation, high noise of experimental measurements, and insufficient number of experimental measurements. Imposing additional constrai
Externí odkaz:
https://doaj.org/article/413cb5c9b34a4dda9aa698aa417cebe0