Synthesis, in vitro pharmacology and radiosynthesis of N-(cis-4-fluoromethylcyclohexyl)-4-(1(H)-imidazol-4-yl)piperidine-1 -thiocarbonamide (VUF 5000), a potential pet ligand for the histamine H3 receptor

Autor: Windhorst, Albert D., Timmerman, Henk, Menge, Wiro M P B, Leurs, Rob, Herscheid, Jacobus D M

Publikováno v: Windhorst, A D, Timmerman, H, Menge, W M P B, Leurs, R & Herscheid, J D M 1999, ' Synthesis, in vitro pharmacology and radiosynthesis of N-(cis-4-fluoromethylcyclohexyl)-4-(1(H)-imidazol-4-yl)piperidine-1-thiocarbonamide (VUF 5000), a potential pet ligand for the histamine H3 receptor ', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 42, no. 3, pp. 293-307 . https://doi.org/10.1002/(SICI)1099-1344(199903)42:3<293::AID-JLCR191>3.0.CO;2-B
Journal of Labelled Compounds and Radiopharmaceuticals, 42(3), 293-307. John Wiley and Sons Ltd

The synthesis of N-(cis-4-fluoromethylcyclohexyl)-4-(1(H)-imidazol-4-yl)piperidine-1 -thiocarbonamide (VUF 5000) 3, a fluorinated analogue of the potent (pA2 value of 8.9 ± 0.1, K(i) = 4.3 ± 0.9 nM) histamine H3 receptor antagonist thioperamide 2 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::925f2099a4acee639bd65dd783d6d07f
https://research.vumc.nl/en/publications/c544e33d-73ee-4ff0-9ad9-60934733476d

A Qualitative Model for the Histamine H3 Receptor Explaining Agonistic and Antagonistic Activity Simultaneously.

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Synthesis, in vitro pharmacology and radiosynthesis of N-( cis-4-fluoromethylcycloyhexyl)-4-(1(H)-imidazol-4-yl)piperidine-11-thiocarbonamide (VUF 5000), a potential PET ligand for the histamine H3 receptor.

Autor: Windhorst, Albert D., Timmerman, Henk, Menge, Wiro M. P. B., Leurs, Rob, Herscheid, Jacobus D. M.

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