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Akademický článek

Betaine delays age‐related muscle loss by mitigating Mss51‐induced impairment in mitochondrial respiration via Yin Yang1

Autor: Si Chen, Tongtong He, Jiedong Chen, Dongsheng Wen, Chen Wang, Wenge Huang, Zhijun Yang, Mengtao Yang, Mengchu Li, Siyu Huang, Zihui Huang, Huilian Zhu

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 2104-2117 (2024)

Abstract Background Mitochondrial dysfunction is one of the hallmarks of aging and a leading contributor to sarcopenia. Nutrients are essential for improving mitochondrial function and skeletal muscle health during the aging process. Betaine is a nut

Externí odkaz: https://doaj.org/article/451c8f7fa99b48b296cc8ca5cf2196c3

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Akademický článek

Open-source interactive design platform for 3D-printed microfluidic devices

Autor: Yushen Zhang, Mengchu Li, Tsun-Ming Tseng, Ulf Schlichtmann

Publikováno v: Communications Engineering, Vol 3, Iss 1, Pp 1-13 (2024)

Abstract Microfluidics and 3D printing offer exciting opportunities for the development of new technologies and applications in the fields of biology, chemistry, and medicine. However, the design of 3D-printed microfluidic devices remains a challengi

Externí odkaz: https://doaj.org/article/8852d4d8baa1419dac6a822767019f9b

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Akademický článek

Effects of Selective and Mixed-Action Kappa and Delta Opioid Receptor Agonists on Pain-Related Behavioral Depression in Mice

Autor: S. Stevens Negus, Celsey M. St. Onge, Young K. Lee, Mengchu Li, Kenner C. Rice, Yan Zhang

Publikováno v: Molecules, Vol 29, Iss 14, p 3331 (2024)

We recently developed a series of nalfurafine analogs (TK10, TK33, and TK35) that may serve as non-addictive candidate analgesics. These compounds are mixed-action agonists at the kappa and delta opioid receptors (KOR and DOR, respectively) and produ

Externí odkaz: https://doaj.org/article/3bd22c861a0e4555aaa74314112260cd

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Akademický článek

LightR: A Fault-Tolerant Wavelength-Routed Optical Networks-on-Chip Topology

Autor: Zhidan Zheng, Mengchu Li, Tsun-Ming Tseng, Ulf Schlichtmann

Publikováno v: Applied Sciences, Vol 13, Iss 15, p 8871 (2023)

Optical networks-on-chip (NoCs) have emerged as a next-generation solution to overcome the limitations of electrical NoCs. In particular, wavelength-routed optical networks-on-chip (WRONoCs) are well known for their high bandwidth and ultra-low signa

Externí odkaz: https://doaj.org/article/cd2cfbf5cea64538a9ca7f7223313141

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Akademický článek

Agonist-Promoted Phosphorylation and Internalization of the Kappa Opioid Receptor in Mouse Brains: Lack of Connection With Conditioned Place Aversion

Autor: Chongguang Chen, Peng Huang, Kathryn Bland, Mengchu Li, Yan Zhang, Lee-Yuan Liu-Chen

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Selective kappa opioid receptor (KOR) agonists are promising antipruritic agents and analgesics. However, clinical development of KOR agonists has been limited by side effects, including psychotomimetic effects, dysphoria, and sedation, except for na

Externí odkaz: https://doaj.org/article/b6b3def666d547b68d79b7c05e40fed6

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