Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Mengchao, Cui"'
Autor:
Ming Ni, Xingxing Zhu, Kaixuan Wang, Wenliang Guo, Qin Shi, Yuying Li, Mengchao Cui, Qiang Xie
Publikováno v:
ACS Omega, Vol 9, Iss 32, Pp 34675-34683 (2024)
Externí odkaz:
https://doaj.org/article/0238c755056f4f2a97f0dc906147ba95
Autor:
Cao Lu, Cong Meng, Yuying Li, Jinling Yuan, Xiaojun Ren, Liang Gao, Dongdong Su, Kai Cao, Mengchao Cui, Qing Yuan, Xueyun Gao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract To date, earlier diagnosis of Alzheimer’s disease (AD) is still challenging. Recent studies revealed the elevated expression of connective tissue growth factor (CTGF) in AD brain is an upstream regulator of amyloid-beta (Aβ) plaque, thus
Externí odkaz:
https://doaj.org/article/84c90d6c83f3430d926b57c7e80ad011
Autor:
Meiqi Wu, Chao Ren, Chenhui Mao, Liling Dong, Bo Li, Xueqian Yang, Zhenghai Huang, Haiqiong Zhang, Yuying Li, Mengshi Yan, Qi Ge, Runze Wu, Feng Feng, Mengchao Cui, Jing Gao, Li Huo
Publikováno v:
NeuroImage, Vol 298, Iss , Pp 120779- (2024)
[18F]-Florbetazine ([18F]-92) is a selective PET tracer for β-amyloid (Aβ) depositions with a novel diaryl-azine scaffold to reduce lipophilicity and to achieve higher gray-to-white matter contrast. We aimed to assess its diagnostic value in Alzhei
Externí odkaz:
https://doaj.org/article/5d31dd3711724024be285c142a7fafe2
Autor:
Ying Zhang, Tao Wang, Xiaojun Zhang, Winnie Deuther-Conrad, Hualong Fu, Mengchao Cui, Jinming Zhang, Peter Brust, Yiyun Huang, Hongmei Jia
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1406-1415 (2022)
We have discovered and synthesized a series of indole-based derivatives as novel sigma-2 (σ2) receptor ligands. Two ligands with high σ2 receptor affinity and subtype selectivity were then radiolabeled with F-18 in good radiochemical yields and pur
Externí odkaz:
https://doaj.org/article/852acf27fe804af4bcfde41df30ae36c
Autor:
Liping Fu, Jinming Zhang, Kaixiang Zhou, Xiaojun Zhang, Hengge Xie, Mingwei Zhu, Mengchao Cui, Ruimin Wang
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
ObjectiveTo evaluate the effectiveness of a new tracer (S)-1-(4-(6-(dimethylamino)quinoxalin-2-yl)phenoxy)-3-fluoropropan-2-ol ([18F]-S16), in distinguishing patients with AD from HCs.MethodsPaired [18F]-S16 and [18F]-THK5317 scans were acquired in f
Externí odkaz:
https://doaj.org/article/65a70d2522c94b9d95ccb25762a3a618
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2022)
Background: The goal of this study was to report a fully automated radiosynthetic procedure of a novel tau tracer [18F]-S16 and its safety, biodistribution, and dosimetry in healthy volunteers as well as the potential utility of [18F]-S16 positron em
Externí odkaz:
https://doaj.org/article/ebb1245da22e44d38a3ec7a9b4499078
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2022)
Purpose: This prospective trial aimed to evaluate the safety, dosimetry, and biodistribution of a novel theranostic probe 68Ga-DOTA-DiPSMA. Also, we have performed the first preliminary application with 68Ga-DOTA-DiPSMA in prostate cancer (PCa) patie
Externí odkaz:
https://doaj.org/article/d57b33788e3c4b64a70a2658c533bad1
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Breast cancer is the most common malignancy among women. Inorganic pyrophosphatase 1 (PPA1) is a multifunctional protein involved in the development of several tumors. However, the role of PPA1 in breast cancer progression remains unclear. In this st
Externí odkaz:
https://doaj.org/article/1b16bd9da9304ff0989ab567b1290a21
Publikováno v:
Journal of Medicinal Chemistry. 66:6889-6904
Autor:
Xiaohui Luan, Haoxi Zhou, Yimin Chen, Xiaojun Zhang, Mengchao Cui, Kuang Chen, Xiaodan Xu, Jinming Zhang, Baixuan Xu
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1252 (2022)
Purpose: Prostate cancer (PCa) is characterized by high expression of prostate-specific 1membrane antigen (PSMA), a type II transmembrane protein. Prostate-specific membrane antigen positron emission tomography (PSMA PET) has high sensitivity and spe
Externí odkaz:
https://doaj.org/article/8afe7e07323b4ef1899fb3ac1335553e