Výsledky vyhledávání

Resveratrol reduces DRP1‐mediated mitochondrial dysfunction via the SIRT1‐PGC1α signaling pathway in manganese‐induced nerve damage in mice

Autor: Bin Xu, Lin Cong, Yu Deng, Meng-Yu Lei, Wei Liu, Kuan Liu, Jing Li, Zhuo-Fan Liu, Zhi-Qi Liu, Zhuo Ma

Publikováno v: Environmental Toxicology. 37:282-298

Excessive manganese (Mn) exposure can cause nerve damage and mitochondrial dysfunction, which may involve defects in mitochondrial dynamics. Resveratrol (RSV) exerts a wide range of beneficial effects via activation of sirtuin 1 (SIRT1) and thus may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfe544cea9dcbe3b589843dfa396ed5
https://doi.org/10.1002/tox.23397

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Melatonin attenuates manganese-induced mitochondrial fragmentation by suppressing the Mst1/JNK signaling pathway in primary mouse neurons

Autor: Zhuo-Fan Liu, Kuan Liu, Zhi-Qi Liu, Lin Cong, Meng-Yu Lei, Jing Li, Zhuo Ma, Yu Deng, Wei Liu, Bin Xu

Publikováno v: The Science of the total environment. 844

Manganese (Mn) toxicity is mainly caused by excessive Mn content in drinking water and occupational exposure. Moreover, overexposure to Mn can impair mental, cognitive, memory, and motor capacities. Although melatonin (Mel) can protect against Mn-ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0f0eb2942826c3e1e99826945b66dd
https://pubmed.ncbi.nlm.nih.gov/35792268

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Resveratrol attenuates manganese-induced oxidative stress and neuroinflammation through SIRT1 signaling in mice

Autor: Meng-Yu Lei, Jing Li, Bin Xu, Wei Liu, Zhuo-Fan Liu, Lin Cong, Yu Deng, Kuan Liu, Zhi-Qi Liu, Zhuo Ma

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 153

Exposure to excess levels of manganese (Mn) leads to neurotoxicity. Increasing evidence demonstrates that oxidative stress and neuroinflammation are important pathological causes of neurotoxicity. Resveratrol (Rsv), a sirtuin-1 (SIRT1) activator, pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0a0695aae2ab17d5eeab1904807024
https://pubmed.ncbi.nlm.nih.gov/34029668

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Manganese-induced alpha-synuclein overexpression aggravates mitochondrial damage by repressing PINK1/Parkin-mediated mitophagy

Autor: Zhuo-Fan Liu, Meng-Yu Lei, Kuan Liu, Wei Liu, Yu Deng, Jing Li, Lin Cong, Zhi-Qi Liu, Zhuo Ma, Bin Xu

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 152

Chronic manganese (Mn) exposure is related to elevated risks of neurodegenerative diseases, and mitochondrial dysfunction is considered a critical pathophysiological feature of Mn neurotoxicity. Although previous research has demonstrated Mn-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3993c7b9b26313fe86cf58f0c0d80a74
https://pubmed.ncbi.nlm.nih.gov/34772531

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Corrigendum to 'Manganese-induced alpha-synuclein overexpression aggravates mitochondrial damage by repressing PINK1/Parkin-mediated mitophagy' [Food Chem. Toxicol. 152 (2021) 112213]

Autor: Lin Cong, Jing Li, Wei Liu, Yu Deng, Meng-Yu Lei, Bin Xu, Zhi-Qi Liu, Kuan Liu, Zhuo Ma, Zhuo-Fan Liu

Publikováno v: Food and Chemical Toxicology. 158:112660

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2847463cccd4d2f8a14023862d11f817
https://doi.org/10.1016/j.fct.2021.112660

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