Suppression of multiple processes relevant to cancer progression by benzyl isothiocyanate may result from the inhibition of Aurora A kinase activity

Autor: Meng Ya Chang, Yi-Jen Hsieh, Chih-Jui Chang, Tzu-Tung Yu

Publikováno v: Food & Function. 11:9010-9019

Cruciferous vegetables are good sources of phytochemicals that have the potential to prevent cancer. Benzyl isothiocyanate (BITC) is the hydrolysis product of glucosinolates that are especially abundant in cruciferous vegetables. The anti-cancer acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1010ebd3e44a4eb98726dcbea94de0e0
https://doi.org/10.1039/d0fo01565b

Haemoglobin in pelvic fluid rescues Fallopian tube epithelial cells from reactive oxygen species stress and apoptosis

Autor: Hsuan-Shun Huang, Meng-Ya Chang, Sung-Chao Chu, Pao-Chu Chen, Dah-Ching Ding, Che-Fang Hsu, Tang-Yuan Chu

Publikováno v: The Journal of Pathology. 240:484-494

Fallopian tube fimbrial epithelium is considered to be the major site of origin of ovarian high-grade serous carcinoma, with p53 loss being the earliest and universal change. We previously reported that reactive oxygen species (ROS) in the ovulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd9a308da825d537a40e4aae4a4742f6
https://doi.org/10.1002/path.4807

Phenethyl Isothiocyanate Inhibits In Vivo Growth of Xenograft Tumors of Human Glioblastoma Cells

Autor: Fei Ting Hsu, Hsu Tung Lee, Rick Sai-Chuen Wu, Kuang Chi Lai, Tomor Harnod, Yea Jiuan Liang, Chiung Chyi Shen, Meng Ya Chang, Jing Gung Chung, Yu Cheng Chou

Publikováno v: Molecules, Vol 23, Iss 9, p 2305 (2018)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Volume 23
Issue 9

Phenethyl isothiocyanate (PEITC) from cruciferous vegetables can inhibit the growth of various human cancer cells. In previous studies, we determined that PEITC inhibited the in vitro growth of human glioblastoma GBM 8401 cells by inducing apoptosis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e961a5f5084b8c283766ce2e9b989902
http://www.mdpi.com/1420-3049/23/9/2305

PEITC inhibits human brain glioblastoma GBM 8401 cell migration and invasion through the inhibition of uPA, Rho A, and Ras with inhibition of MMP-2, -7 and -9 gene expression

Autor: Hsin Chung Liu, Mei Jen Wang, Chih Huang Hung, Meng Ya Chang, Tomor Harnod, Hsu Tung Lee, Yu Cheng Chou, Jing Gung Chung, Fu Shun Yu

Publikováno v: Oncology Reports. 34:2489-2496

Glioblastoma is the most aggressive primary brain malignancy, and the efficacy of multimodality treatments remains unsatisfactory. Phenethyl isothiocyanate (PEITC), one member of the isothiocyanate family, was found to inhibit the migration and invas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629b0828f209136639e11ac552e29dde
https://doi.org/10.3892/or.2015.4260

Kallistatin Ameliorates Influenza Virus Pathogenesis by Inhibition of Kallikrein-Related Peptidase 1-Mediated Cleavage of Viral Hemagglutinin

Autor: Shainn Wei Wang, Chia Hsing Leu, Ai Li Shiau, Yao Chang, Yi Cheng Chen, Nai Hui Chung, Julie Chao, Yen Jang Huang, Meng Ya Chang, Mei Lin Yang, Gia Shing Shieh, Yu Chu Su, Chia Cheng Lin, Chao Liang Wu, Lee Chao

Publikováno v: Antimicrobial Agents and Chemotherapy

Proteolytic cleavage of the hemagglutinin (HA) of influenza virus by host trypsin-like proteases is required for viral infectivity. Some serine proteases are capable of cleaving influenza virus HA, whereas some serine protease inhibitors (serpins) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708658ac241f33822f437b2a6122a6e3