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3-butyl-6-fluoro-1(3H)-isobenzofuranone (6-F-NBP), a derivative of dl-n-butylphthalide, inhibits glutamate-induced cytotoxicity in PC12 cells

Autor: Meng-Xue Ji, Na Zhao, Ling Xu, Bian-Sheng Ji

Publikováno v: Drug Development Research. 73:11-17

It is widely recognized that glutamate (Glu)-induced cytotoxicity, intracellular calcium overload and the excessive free radical production are key events in the development and progression of ischemic brain injury. dl-3-n-butylphthalide (NBP), an an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0c1012eda266b729d56a170af281d0d
https://doi.org/10.1002/ddr.20444

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3-butyl-6-fluoro-1 (3H)-isobenzofuranone, a derivative of dl-n-butylphthalide, attenuates hydrogen peroxide-induced damage in PC12 cells

Autor: Bian-Sheng Ji, Meng-Xue Ji, Ling Xu, Na Zhao

Publikováno v: Drug Development Research. 72:259-264

The anti-cerebral ischemia agent, dl-3-n-butylphthalide (NBP), is effective in models of vascular dementia in animals. The present study investigates the protective effect of 3-butyl-6-fluoro-1 (3H)-isobenzofuranone (6-F-NBP), a fluoro derivative of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4d7e04cd45a0b9cafb79a7ea8543c8a
https://doi.org/10.1002/ddr.20393

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