A G-quadruplex stabilizer, CX-5461 combined with two immune checkpoint inhibitors enhances in vivo therapeutic efficacy by increasing PD-L1 expression in colorectal cancer

Autor: Shin-Yi Chung, Yu-Chan Chang, Dennis Shin-Shian Hsu, Ya-Chi Hung, Meng-Lun Lu, Yi-Ping Hung, Nai-Jung Chiang, Chun-Nan Yeh, Michael Hsiao, John Soong, Yeu Su, Ming-Huang Chen

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 35, Iss , Pp 100856- (2023)

Purpose: Immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy can improve the limited efficacy of colorectal cancer (CRC) immunotherapy. CX-5461 causes substantial DNA damage and genomic instability and can increase ICIs’ t

Externí odkaz: https://doaj.org/article/eae41350494446be825f26c9caba4d14

Establishment of a novel gene panel as a biomarker of immune checkpoint inhibitor response

Autor: Yi‐Ru Pan, Chiao‐En Wu, Yu‐Chao Wang, Yi‐Chen Yeh, Meng‐Lun Lu, Yi‐Ping Hung, Yee Chao, Da‐Wei Yeh, Chien‐Hsing Lin, Jason Chia‐Hsun Hsieh, Ming‐Huang Chen, Chun‐Nan Yeh

Publikováno v: Clinical & Translational Immunology, Vol 9, Iss 7, Pp n/a-n/a (2020)

Abstract Objective Immune checkpoint inhibitors (ICIs) have become the standard of care in various cancers, although the predictive tool is still unknown. Methods This study aimed to develop a novel gene panel by selecting DNA damage response (DDR) g

Externí odkaz: https://doaj.org/article/32eaf414769d41edbd652067a66e7adf

Inhibition of IL-1β-induced COX-2 and IL-8 Expression by Histone Deacetylase Inhibitor Trichostatin A (TSA) in Human Lung Adenocarcinoma Cells

Autor: Meng-Lun Lu, 呂孟倫

98
Chronic inflammation has been proposed to be associated with cancer progression, and indeed the pro-inflammatory cytokine interleukin (IL)-1β was shown to up-regulate the expression of several inflammation-related genes, such as cyclooxygena

Externí odkaz: http://ndltd.ncl.edu.tw/handle/21082418530547281607

Rapid Control of a SARS-CoV-2 B.1.617.2 (Delta) Variant COVID-19 Community Outbreak: The Successful Experience in Pingtung County of Taiwan

Autor: Cherng-Gueih Shy, Jian-He Lu, Hui-Chen Lin, Min-Nan Hung, Hsiu-Chun Chang, Meng-Lun Lu, How-Ran Chao, Yao-Shen Chen, Pi-Sheng Wang

Publikováno v: International Journal of Environmental Research and Public Health; Volume 19; Issue 3; Pages: 1421
International Journal of Environmental Research and Public Health, Vol 19, Iss 1421, p 1421 (2022)

The Severe Acute Respiratory Syndrome-associated Coronavirus 2 (SARS-CoV-2) was an outbreak in December, 2019 and rapidly spread to the world. All variants of SARS-CoV-2, including the globally and currently dominant Delta variant (Delta-SARS-CoV-2),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018b886760ab5c44db8f5972ede6a0e2

Combined Microsatellite Instability and Elevated Microsatellite Alterations at Selected Tetranucleotide Repeats (EMAST) Might Be a More Promising Immune Biomarker in Colorectal Cancer

Autor: Yee Chao, Shung Haur Yang, Chien Hsing Lin, Yuan Tzu Lan, Wen Yi Liang, Jiun I. Lai, Hung Hsin Lin, Pei Ching Lin, Meng Lun Lu, Shih Ching Chang, Ming Huang Chen, Chun Chi Lin, Muh Hwa Yang

Publikováno v: The Oncologist. 24:1534-1542

Background The form of microsatellite instability (MSI) affecting tetranucleotide repeats known as elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) has emerged as a new potential biomarker in multiple cancers. In colore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a94a5f854334e325a53b448eb12ab74
https://doi.org/10.1634/theoncologist.2019-0171