Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Meng-Lu Liu"'
Autor:
Meng-Lu Liu, Shuaipeng Ma, Wenjiao Tai, Xiaoling Zhong, Haoqi Ni, Yuhua Zou, Jingcheng Wang, Chun-Li Zhang
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Effective therapeutics is much needed for amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease mainly affecting motor neurons. By screening chemical compounds in human patient-derived and aging-relevant motor neurons
Externí odkaz:
https://doaj.org/article/8de14841118a4091a8c6c8aac7b2349e
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 1043-1050 (2020)
Transcription factors play key roles in cell-fate decisions by regulating 3D genome conformation and gene expression. The traditional view is that methylation of DNA hinders transcription factors binding to them, but recent research has shown that ma
Externí odkaz:
https://doaj.org/article/311fb0858d994079a55ede95c6c76962
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-14 (2020)
Abstract Background Alzheimer’s disease (AD) is an adult-onset mental disorder with aging as a major risk factor. Early and progressive degeneration of basal forebrain cholinergic neurons (BFCNs) contributes substantially to cognitive impairments o
Externí odkaz:
https://doaj.org/article/a5c276bc190a4cebb63bd43ff52bf1f8
Autor:
Hao Lv, Fu-Ying Dao, Dan Zhang, Zheng-Xing Guan, Hui Yang, Wei Su, Meng-Lu Liu, Hui Ding, Wei Chen, Hao Lin
Publikováno v:
iScience, Vol 23, Iss 4, Pp - (2020)
Summary: 5hmC, 6mA, and 4mC are three common DNA modifications and are involved in various of biological processes. Accurate genome-wide identification of these sites is invaluable for better understanding their biological functions. Owing to the lab
Externí odkaz:
https://doaj.org/article/6467ae3bb7f248ce9412ec3f8be937f4
Publikováno v:
Stem Cell Reports, Vol 7, Iss 5, Pp 955-969 (2016)
Pro-neural transcription factors and small molecules can induce the reprogramming of fibroblasts into functional neurons; however, the immediate-early molecular events that catalyze this conversion have not been well defined. We previously demonstrat
Externí odkaz:
https://doaj.org/article/7d79580104844eddae9d6274ce2d12d1
Publikováno v:
Cell Reports, Vol 14, Iss 1, Pp 115-128 (2016)
Subtype-specific neurons obtained from adult humans will be critical to modeling neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). Here, we show that adult human skin fibroblasts can be directly and efficiently converted into h
Externí odkaz:
https://doaj.org/article/06b6a1fb70de46fb937f8aa7047da8f1
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
In vitro generation of motor neurons (MNs) is a promising approach for modeling motor neuron diseases (MNDs) such as amyotrophic lateral sclerosis (ALS). As aging is a leading risk factor for the development of neurodegeneration, it is important to r
Externí odkaz:
https://doaj.org/article/9c19086b74194312bdf8dbf9c02e2092
Autor:
Yu-Xue Gao, Qi-Qi Ning, Peng-Xiang Yang, Yuan-Yue Guan, Peng-Xiang Liu, Meng-Lu Liu, Lu-Xin Qiao, Xiang-Hua Guo, Tong-Wang Yang, De-Xi Chen
Publikováno v:
World Journal of Hepatology. 15:460-476
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::928c69cf0d833168831461616c62a6c4
https://doi.org/10.4254/wjh.v15.i4.460
https://doi.org/10.4254/wjh.v15.i4.460
Autor:
Meng-Lu Liu, Shuaipeng Ma, Wenjiao Tai, Xiaoling Zhong, Haoqi Ni, Yuhua Zou, Jingcheng Wang, Chun-Li Zhang
Effective therapeutics is much needed for amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease mainly affecting motor neurons. By screening chemical compounds in human patient-derived and aging-relevant motor neurons, we iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd1b4d476fe1b9d6dab5b9bb72c2ac1b
https://doi.org/10.1101/2023.04.24.538014
https://doi.org/10.1101/2023.04.24.538014
Publikováno v:
Current Medicinal Chemistry. 29:789-806
Abstract: Protein-ligand interactions are necessary for majority protein functions. Adenosine- 5’-triphosphate (ATP) is one such ligand that plays vital role as a coenzyme in providing energy for cellular activities, catalyzing biological reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de60867066e959d07191bef646b90e5
https://doi.org/10.2174/0929867328666210910125802
https://doi.org/10.2174/0929867328666210910125802