Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Meng-Kwoon Sim"'
Autor:
Hong Wang, Meng-Kwoon Sim, Weng Keong Loke, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Feng Ru Tang, Gautam Sethi
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
This study was aimed to evaluate the possible protective effects of ursolic acid (UA) against gamma radiation induced damage both in vitro as well as in vivo. It was observed that the exposure to gamma radiation dose- and time-dependently caused a si
Externí odkaz:
https://doaj.org/article/57b31acd5042449aae95c860096486c9
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138009 (2015)
ACE inhibitors and ARBs (angiotensin receptor blockers) have been shown to attenuate radiation injuries in animal models of lethal gamma irradiation. These two classes of drug act by curtailing the actions of angiotensin II-linked inflammatory pathwa
Externí odkaz:
https://doaj.org/article/27a04f09cf4a40a8b0751ee0c34467b5
Publikováno v:
Drugs in R&D
In an earlier single-dose escalation study to evaluate the safety and pharmacokinetics of orally administered des-aspartate-angiotensin I (DAA-I) in healthy subjects, the plasma level of DAA-I could not be determined because DAA-I is rapidly degraded
Publikováno v:
Drugs in R&D
Des-aspartate-angiotensin I (DAA-I) is an endogenous angiotensin peptide and a prototype angiotensin receptor agonist (ARA). It acts on the angiotensin AT1 receptor and antagonises the deleterious actions of angiotensin II. DAA-I attenuates animal mo
Autor:
Meng-Kwoon Sim
Publikováno v:
European Journal of Pharmacology. 760:36-41
The review describes DAA-I (des-aspartate-angiotensin-I) as a prototype of a novel class of drugs that acts as agonists on the angiotensin AT1 receptor or ARAs (angiotensin receptor agonists). DAA-I is a component of the renin angiotensin system. Ear
Publikováno v:
European Journal of Pharmacology. 683:310-315
The high frequency of rhinovirus (RV) infection and the lack of an effective treatment, underline the importance of research on novel anti-rhinoviral agents. The present study investigated the effects of des-aspartate-angiotensin I (DAA-I) on the sur
Publikováno v:
Biochemical Pharmacology. 82:1198-1208
Although clinical studies suggested that blockade of the renin-angiotensin system may prevent diabetes, the mechanism is uncertain. As a follow-up to an earlier study, we investigated how des-aspartate-angiotensin-1 (DAA-1) and its metabolite, angiot
Publikováno v:
Endocrinology. 148:5925-5932
The present study investigated the hypoglycemic action of des-aspartate-angiotensin I (DAA-I), a metabolite of angiotensin I, in two animal models of type 2 diabetes. The rationale was based on our earlier studies demonstrating that DAA-I acts on the
Publikováno v:
European Journal of Pharmacology. 561:144-150
Angiotensin 1-7, a heptapeptide derived from metabolism of either angiotensin I or angiotensin II, is a biologically active peptide of the renin– angiotensin system. The present study investigated the effect of angiotensin 1-7 on the vasopressor ac
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0138009 (2015)
PLoS ONE, Vol 10, Iss 9, p e0138009 (2015)
ACE inhibitors and ARBs (angiotensin receptor blockers) have been shown to attenuate radiation injuries in animal models of lethal gamma irradiation. These two classes of drug act by curtailing the actions of angiotensin II-linked inflammatory pathwa