Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Meng-Di Yin"'
Autor:
Juan-Juan Zhao, Xin-Yu Sun, Sai-Ning Tian, Zong-Ze Zhao, Meng-Di Yin, Mei Zhao, Feng Zhang, Si-Ang Li, Zhi-Xue Yang, Wei Wen, Tao Cheng, An Gong, Jian-Ping Zhang, Xiao-Bing Zhang
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background CRISPR-Cas9 technology has advanced in vivo gene therapy for disorders like hemophilia A, notably through the successful targeted incorporation of the F8 gene into the Alb locus in hepatocytes, effectively curing this disorder in
Externí odkaz:
https://doaj.org/article/6b00ee3c16a94b60a7273e094f61df57
Autor:
Wei Wen, Zi-Jun Quan, Si-Ang Li, Zhi-Xue Yang, Ya-Wen Fu, Feng Zhang, Guo-Hua Li, Mei Zhao, Meng-Di Yin, Jing Xu, Jian-Ping Zhang, Tao Cheng, Xiao-Bing Zhang
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)
Abstract Background After repairing double-strand breaks (DSBs) caused by CRISPR-Cas9 cleavage, genomic damage, such as large deletions, may have pathogenic consequences. Results We show that large deletions are ubiquitous but are dependent on editin
Externí odkaz:
https://doaj.org/article/df51a80f1e864427bde4af68b40acd79
Autor:
Jian-Ping Zhang, Xin-Xin Cheng, Mei Zhao, Guo-Hua Li, Jing Xu, Feng Zhang, Meng-Di Yin, Fei-Ying Meng, Xin-Yue Dai, Ya-Wen Fu, Zhi-Xue Yang, Cameron Arakaki, Ruijun Jeanna Su, Wei Wen, Wen-Tian Wang, Wanqiu Chen, Hannah Choi, Charles Wang, Guangping Gao, Lei Zhang, Tao Cheng, Xiao-Bing Zhang
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background Hemophilia A, a bleeding disorder resulting from F8 mutations, can only be cured by gene therapy. A promising strategy is CRISPR-Cas9-mediated precise insertion of F8 in hepatocytes at highly expressed gene loci, such as albumin (
Externí odkaz:
https://doaj.org/article/0175546634cc4b5da1856d314090ad7d
Publikováno v:
Medicine; 2/23/2024, Vol. 103 Issue 8, p1-5, 5p
Autor:
Feng Zhang, Tao Cheng, Jing Xu, Guo-Hua Li, Juan-Juan Zhao, Mei Zhao, Xiao-Bing Zhang, Meng-Di Yin, Yi-Dan Sun, Xin-Yu Sun, Beldon Zhang, Jian-Ping Zhang, Fei-Ying Meng, Si-Ang Li
Publikováno v:
Human Gene Therapy. 33:404-420
Hemophilia A (HA) is a monogenic disease characterized by plasma clotting factor 8 (F8) deficiency due to F8 mutation. We have been attempting to cure HA permanently using a CRISPR-Cas9 gene-editing strategy. Here, we induced targeted integration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e236c65da5999ab9a6bdb19285b223a
https://doi.org/10.1089/hum.2021.145
https://doi.org/10.1089/hum.2021.145
Autor:
Jing Xu, Mei Zhao, Wei Wen, Meng-Di Yin, Zi-Jun Quan, Tao Cheng, Ya-Wen Fu, Guo-Hua Li, Feng Zhang, Xiao-Bing Zhang, Zhi-Xue Yang, Jian-Ping Zhang, Si-Ang Li
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)
Genome Biology
Genome Biology
BackgroundAfter repairing double-strand breaks (DSBs) caused by CRISPR-Cas9 cleavage, genomic damage, such as large deletions, may have pathogenic consequences.ResultsWe show that large deletions are ubiquitous but are dependent on editing sites and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a207dbedddc97e3343e53f19f85f6a9
https://doaj.org/article/df51a80f1e864427bde4af68b40acd79
https://doaj.org/article/df51a80f1e864427bde4af68b40acd79
Autor:
Tao Cheng, Xin-Yue Dai, Guo-Hua Li, Xin-Xin Cheng, Fei-Ying Meng, Wen-Tian Wang, Feng Zhang, Jian-Ping Zhang, Ruijun Jeanna Su, Guangping Gao, Wanqiu Chen, Zhi-Xue Yang, Wei Wen, Jing Xu, Hannah Choi, Meng-Di Yin, Charles Wang, Xiao-Bing Zhang, Cameron Arakaki, Ya-Wen Fu, Lei Zhang, Mei Zhao
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-17 (2019)
Genome Biology
Genome Biology
Background Hemophilia A, a bleeding disorder resulting from F8 mutations, can only be cured by gene therapy. A promising strategy is CRISPR-Cas9-mediated precise insertion of F8 in hepatocytes at highly expressed gene loci, such as albumin (Alb). Unf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec7d067ef4ed93caf644a5f740f8148
https://doaj.org/article/0175546634cc4b5da1856d314090ad7d
https://doaj.org/article/0175546634cc4b5da1856d314090ad7d
Publikováno v:
Energies, Vol 9, Iss 3, p 209 (2016)
The pulse-based charging method for battery cells has been recognized as a fast and efficient way to overcome the shortcoming of a slow charging time in distributed battery cells, which is regarded as a connection of cells such as the Internet of Thi
Externí odkaz:
https://doaj.org/article/39c68be8ae8643d4b96cea5f82eb0740
Autor:
Zhang, Jian-Ping, Cheng, Xin-Xin, Zhao, Mei, Li, Guo-Hua, Xu, Jing, Zhang, Feng, Meng-Di Yin, Fei-Ying Meng, Dai, Xin-Yue, Fu, Ya-Wen, Yang, Zhi-Xue, Arakaki, Cameron, Ruijun Su, Wen, Wei, Wen-Tian Wang, Wanqiu Chen, Choi, Hannah, Wang, Charles, Guangping Gao, Zhang, Lei, Cheng, Tao, Zhang, Xiao-Bing
Additional file 1: Figure S1. Efficient cleavage of Cas9-sgAlb-E14 at the Alb stop codon. Figure S2. High-level knock-in efficiency mediated by the double-cut donor. Figure S3. PCR and sequencing analysis confirmed BDDF8 knock-in at Alb stop codon me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8914c881599799094f3ce8f44d9f98
Publikováno v:
Transactions of the Korean Society of Automotive Engineers. 24:112-121
AFLS (Adaptive front lighting system) is being applied to improve safety in driving automotive at night. Safe embedded system design for controlling head-lamps is required to improve noise robust ECU hardware and software simultaneously by considerin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4138de2e689ac08c8aa3c43e46bc688b
https://doi.org/10.7467/ksae.2016.24.1.112
https://doi.org/10.7467/ksae.2016.24.1.112