Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Meng-Chieh Shen"'
Autor:
Yang Jin, Darby Kozan, Eric D. Young, Monica R. Hensley, Meng-Chieh Shen, Jia Wen, Tabea Moll, Jennifer L. Anderson, Hannah Kozan, John F. Rawls, Steven A. Farber
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 10, Pp 100637- (2024)
Zebrafish are an ideal model organism to study lipid metabolism and to elucidate the molecular underpinnings of human lipid-associated disorders. Unlike murine models, to which various standardized high lipid diets such as a high-cholesterol diet (HC
Externí odkaz:
https://doaj.org/article/159ff70980c24266ae6b70193f1640e1
Autor:
James H. Thierer, Ombretta Foresti, Pradeep Kumar Yadav, Meredith H. Wilson, Tabea O. C. Moll, Meng-Chieh Shen, Elisabeth M. Busch-Nentwich, Margaret Morash, Karen L. Mohlke, John F. Rawls, Vivek Malhotra, M. Mahmood Hussain, Steven A. Farber
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Vertebrates transport hydrophobic triglycerides through the circulatory system by packaging them within amphipathic particles called Triglyceride-Rich Lipoproteins. Yet, it remains largely unknown how triglycerides are loaded onto these part
Externí odkaz:
https://doaj.org/article/0c842b9c7eca4be6a40b1c67e56efa1a
Autor:
James H. Thierer, Ombretta Foresti, Pradeep Kumar Yadav, Meredith H. Wilson, Tabea O. C. Moll, Meng-Chieh Shen, Elisabeth M. Busch-Nentwich, Margaret Morash, Karen L. Mohlke, John F. Rawls, Vivek Malhotra, M. Mahmood Hussain, Steven A. Farber
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/1aabdb2bf28d41d2a79b6d4579ae6e87
Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 3, Pp 283-295 (2017)
Caveolae and their structural protein caveolin 1 (CAV1) have roles in cellular lipid processing and systemic lipid metabolism. Global deletion of CAV1 in mice results in insulin resistance and increases in atherogenic plasma lipids and cholesterol, b
Externí odkaz:
https://doaj.org/article/ff86e8b3ccf140b795d907a5f053f5c2
Autor:
Jennifer L Anderson, Timothy S Mulligan, Meng-Chieh Shen, Hui Wang, Catherine M Scahill, Frederick J Tan, Shao J Du, Elisabeth M Busch-Nentwich, Steven A Farber
Publikováno v:
PLoS Genetics, Vol 13, Iss 11, p e1007105 (2017)
As model organism-based research shifts from forward to reverse genetics approaches, largely due to the ease of genome editing technology, a low frequency of abnormal phenotypes is being observed in lines with mutations predicted to lead to deleterio
Externí odkaz:
https://doaj.org/article/113fcbe6ef3a4950b7f16a238692a5a8
Autor:
Meng-Chieh Shen, 沈孟頡
105
As of July 2016, the total number of convenience stores in Taiwan has exceeded 10,000. The total population of Taiwan's population, with an average population of about 2,300 people, has a convenience store with a density of the world's highe
As of July 2016, the total number of convenience stores in Taiwan has exceeded 10,000. The total population of Taiwan's population, with an average population of about 2,300 people, has a convenience store with a density of the world's highe
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/bt7469
Autor:
James H. Thierer, Ombretta Foresti, Pradeep Kumar Yadav, Meredith H. Wilson, Tabea Moll, Meng-Chieh Shen, Elisabeth M. Busch-Nentwich, Margaret Morash, Karen L. Mohlke, John F. Rawls, Vivek Malhotra, M. Mahmood Hussain, Steven A. Farber
SUMMARYTriglyceride-rich lipoproteins (TRLs) are micelle-like particles that enable efficient transport of lipids throughout the bloodstream, but also promote atherosclerotic cardiovascular disease. Despite this central relevance to cardiovascular di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a49cab08cd4069bee55359cf42e0292
https://doi.org/10.1101/2022.08.02.502564
https://doi.org/10.1101/2022.08.02.502564
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 316:G350-G365
Difficulty in imaging the vertebrate intestine in vivo has hindered our ability to model nutrient and protein trafficking from both the lumenal and basolateral aspects of enterocytes. Our goal was to use live confocal imaging to increase understandin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26a54cda4ae1c2f88a515e9ca984eff
https://doi.org/10.1152/ajpgi.00080.2018
https://doi.org/10.1152/ajpgi.00080.2018
Autor:
Chune Liu, Michael J. Wolfgang, Steven A. Farber, Shan Zhao, Debaditya Mukhopadhyay, Meng Chieh Shen, Wei Shao, Jiwon Hwang, Peter J. Espenshade, Ebru S. Selen
Publikováno v:
The Journal of Biological Chemistry
Oxygen regulates hypoxia-inducible factor (HIF) transcription factors to control cell metabolism, erythrogenesis, and angiogenesis. Whereas much has been elucidated about how oxygen regulates HIF, whether lipids affect HIF activity is un-known. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6645fbc76d3db2c7222fe60363566e
https://pubmed.ncbi.nlm.nih.gov/33109611
https://pubmed.ncbi.nlm.nih.gov/33109611
Autor:
Rolf O. Karlstrom, Matthew D. Loring, Ira Male, Rita R. Fagan, Alyssa Lutservitz, A. Tuba Ozacar, Veronica A. Pace, Meng-Chieh Shen, Christine Devine
While neurogenesis in the adult hypothalamus is now known to be essential for proper function, the cell-cell signaling events that regulate neurogenesis in this evolutionarily conserved brain region remain poorly understood. Here we show that Hedgeho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bbd2380edacf4cdffbcd4353e927d49
https://doi.org/10.1101/740613
https://doi.org/10.1101/740613