Výsledky vyhledávání - "Meng Tiak Toh"

Akademický článek

Targeted next-generation sequencing to diagnose disorders of HDL cholesterol

Autor: Singh N. Sadananda, Jia Nee Foo, Meng Tiak Toh, Lubomira Cermakova, Laia Trigueros-Motos, Teddy Chan, Herty Liany, Jennifer A. Collins, Sima Gerami, Roshni R. Singaraja, Michael R. Hayden, Gordon A. Francis, Jiri Frohlich, Chiea Chuen Khor, Liam R. Brunham

Publikováno v: Journal of Lipid Research, Vol 56, Iss 10, Pp 1993-2001 (2015)

A low level of HDL cholesterol (HDL-C) is a common clinical scenario and an important marker for increased cardiovascular risk. Many patients with very low or very high HDL-C have a rare mutation in one of several genes, but identification of the mol

Externí odkaz: https://doaj.org/article/d70d79cdd481407b9644a9666ec59f06

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Genetic diversity of variants involved in drug response and metabolism in Sri Lankan populations: implications for clinical implementation of pharmacogenomics

Autor: Liam R. Brunham, Sze Ling Chan, Vajira H. W. Dissanayake, Colin J. D. Ross, Meng Tiak Toh, Michael R. Hayden, Bruce Carleton, Yik Ying Teo, Nilakshi Samaranayake

Publikováno v: Pharmacogenetics and Genomics

Supplemental Digital Content is available in the text.
Background Interpopulation differences in drug responses are well documented, and in some cases they correspond to differences in the frequency of associated genetic markers. Understanding t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be4404a7ac06b516b09a4be0122b568
http://europepmc.org/articles/PMC4890825

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A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation

Autor: Sudipto Roy, Meng Tiak Toh, Vijayashankaranarayanan Narasimhan, Semil P. Choksi, Hao Lu, Surin Kumar Thamilselvam

Publikováno v: Developmental Biology. 397(2):225-236

Cilia perform a variety of functions in a number of developmental and physiological contexts, and are implicated in the pathogenesis of a wide spectrum of human disorders. While the ciliary axoneme is assembled by intraflagellar transport, how ciliar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61acdf23b008dfe1d72c170edf07c203

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NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity

Autor: Yan Yan Hou, Xueying Wang, Meng Tiak Toh

Publikováno v: Cell Biochemistry and Function. 30:233-242

Studies revealed that Nijmegen Breakage Syndrome protein 1 (NBS1) plays an important role in maintaining genome stability, but the underlying mechanism is controversial and elusive. Our results using clinical samples showed that NBS1 was involved in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::172b03f3b49f75e96eda400d66feb3e9
https://doi.org/10.1002/cbf.1840

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