Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Meng Han Wu"'
Autor:
Meng-Han Wu, Felipe Valenca-Pereira, Francesca Cendali, Emily L. Giddings, Catherine Pham-Danis, Michael C. Yarnell, Amanda J. Novak, Tonya M. Brunetti, Scott B. Thompson, Jorge Henao-Mejia, Richard A. Flavell, Angelo D’Alessandro, M. Eric Kohler, Mercedes Rincon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Mitochondrial respiration is essential for the survival and function of T cells used in adoptive cellular therapies. However, strategies that specifically enhance mitochondrial respiration to promote T cell function remain limited. Here, we
Externí odkaz:
https://doaj.org/article/d0884f5a1b81480bad4290e7a5d667fa
Autor:
Christopher M Cox, Meng-Han Wu, Marco Padilla-Rodriguez, Isabella Blum, Samina Momtaz, Stefanie A T Mitchell, Jean M Wilson
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0296003 (2024)
Maintenance of the intestinal epithelium requires constant self-renewal and regeneration. Tight regulation of proliferation and differentiation of intestinal stem cells within the crypt region is critical to maintaining homeostasis. The transcription
Externí odkaz:
https://doaj.org/article/f986c9d467cc4e4db3f9735ef88e3c7f
Autor:
Emily L. Giddings, Devin P. Champagne, Meng-Han Wu, Joshua M. Laffin, Tina M. Thornton, Felipe Valenca-Pereira, Rachel Culp-Hill, Karen A. Fortner, Natalia Romero, James East, Phoebe Cao, Hugo Arias-Pulido, Karatatiwant S. Sidhu, Brian Silverstrim, Yoonseok Kam, Shana Kelley, Mark Pereira, Susan E. Bates, Janice Y. Bunn, Steven N. Fiering, Dwight E. Matthews, Robert W. Robey, Domink Stich, Angelo D’Alessandro, Mercedes Rincon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Drug efflux through ABC transporters is a common mechanism leading to chemoresistance in cancer. Here, the authors show that mitochondrial respiration provides ATP to allow ABC transporters activity so mitochondrial respiration inhibition overcomes c
Externí odkaz:
https://doaj.org/article/96cc5e262fc1481b86eceff834f1a9ce
Autor:
Yang-Hsiang Lin, Yu-Chin Liu, Cheng-Yi Chen, Hsiang-Cheng Chi, Meng-Han Wu, Po-Shuan Huang, Cheng-Chih Chang, Tzu-Kang Lin, Chau-Ting Yeh, Kwang-Huei Lin
Publikováno v:
Cells, Vol 11, Iss 16, p 2610 (2022)
Tumor metastasis is a complex process modulated by both intrinsic and extrinsic factors that ultimately result in poorer patient outcomes, including diminished survival. Pseudogene-derived long non-coding RNAs (lncRNA) play important roles in cancer
Externí odkaz:
https://doaj.org/article/22ab67304b3547bab19ad34d0439b3ca
Autor:
Alexander J Neuwelt, Abigail K Kimball, Amber M Johnson, Benjamin W Arnold, Bonnie L Bullock, Rachael E Kaspar, Jeff W Kwak, Meng-Han Wu, Lynn E Heasley, Robert C Doebele, Howard Y Li
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
BackgroundProgrammed death 1/programmed death ligand 1 (PD-1/PD-L1) targeted immunotherapy affords clinical benefit in ~20% of unselected patients with lung cancer. The factor(s) that determine whether a tumor responds or fails to respond to immunoth
Externí odkaz:
https://doaj.org/article/392478c81db649bab2de6e5e9eb696a8
Autor:
Yu-zheng Du, Xin-xin Gao, Cheng-Ting Wang, Hai-zhen Zheng, Yun Lei, Meng-han Wu, Xue-min Shi, Hai-peng Ban, Wen-long Gu, Xiang-gang Meng, Mao-ti Wei, Chun-xiao Hu
Publikováno v:
Trials, Vol 18, Iss 1, Pp 1-10 (2017)
Abstract Background Stroke is the prime cause of morbidity and mortality in the general population, and hypertension will increase the recurrence and mortality of stroke. We report a protocol of a pragmatic randomized controlled trial (RCT) using blo
Externí odkaz:
https://doaj.org/article/b9ff3117d9b647ac9393d81bca2ecab8
Publikováno v:
International Journal of Ophthalmology, Vol 10, Iss 1, Pp 1-5 (2017)
AIM: To identify the disease-causing mutation responsible for the presence of congenital cataract in a Chinese family. METHODS: The study recruited a four-generation Chinese pedigree affected by autosomal dominant congenital cataract (ADCC). Family
Externí odkaz:
https://doaj.org/article/9ca51c7a731745bea3a66b5d69959705
Autor:
Abigail Camenisch, Isabella R. Blum, Stefanie A.T. Mitchell, Meng-Han Wu, Christopher M. Cox, Matthew T Ollerton, Pawel R. Kiela, Marco Padilla-Rodriguez, Vanessa Figliuolo da Paz, John Muller, Curtis A. Thorne, Jean M. Wilson, Samina Momtaz
Publikováno v:
Dev Biol
During postnatal intestinal development, the intestinal epithelium is highly proliferative, and this proliferation is regulated by signaling in the intervillous and crypt regions. This signaling is primarily mediated by Wnt, and requires membrane tra
Publikováno v:
Cells, Vol 9, Iss 2, p 262 (2020)
Thyroid hormone (T3) and its receptor (TR) are involved in cell metabolism and cancer progression. Hypothyroidism is associated with significantly elevated risk of hepatocellular carcinoma (HCC). Levels of the glycoprotein alpha-fetoprotein (AFP) are
Externí odkaz:
https://doaj.org/article/8f89f181dbef4af5adf4f4833a74a597
Publikováno v:
Oncogene. 40:4675-4685
Long non-coding RNAs (lncRNA) play crucial roles in hepatocellular carcinoma (HCC) progression. However, the specific functions of lncRNAs in alternative splicing (AS) and the metastatic cascade in liver cancer remain largely unclear. In this study,