Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Meng C Wang"'
Autor:
Yong Yu, Shihong M Gao, Youchen Guan, Pei-Wen Hu, Qinghao Zhang, Jiaming Liu, Bentian Jing, Qian Zhao, David M Sabatini, Monther Abu-Remaileh, Sung Yun Jung, Meng C Wang
Publikováno v:
eLife, Vol 13 (2024)
Lysosomes are active sites to integrate cellular metabolism and signal transduction. A collection of proteins associated with the lysosome mediate these metabolic and signaling functions. Both lysosomal metabolism and lysosomal signaling have been li
Externí odkaz:
https://doaj.org/article/e0e6d3cb9074413abcb47380357cca41
Autor:
Lucas A Hartsough, Mooncheol Park, Matthew V Kotlajich, John Tyler Lazar, Bing Han, Chih-Chun J Lin, Elena Musteata, Lauren Gambill, Meng C Wang, Jeffrey J Tabor
Publikováno v:
eLife, Vol 9 (2020)
Gut microbial metabolism is associated with host longevity. However, because it requires direct manipulation of microbial metabolism in situ, establishing a causal link between these two processes remains challenging. We demonstrate an optogenetic me
Externí odkaz:
https://doaj.org/article/6f776754ae384b3780c2adadc3fed1cb
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004752 (2014)
Reproductive senescence is a hallmark of aging. The molecular mechanisms regulating reproductive senescence and its association with the aging of somatic cells remain poorly understood. From a full genome RNA interference (RNAi) screen, we identified
Externí odkaz:
https://doaj.org/article/31e3b03dd3ba493ba4938414a6557c73
Autor:
Paola Sebastiani, Monty Montano, Annibale Puca, Nadia Solovieff, Toshio Kojima, Meng C Wang, Efthymia Melista, Micah Meltzer, Sylvia E J Fischer, Stacy Andersen, Stephen H Hartley, Amanda Sedgewick, Yasumichi Arai, Aviv Bergman, Nir Barzilai, Dellara F Terry, Alberto Riva, Chiara Viviani Anselmi, Alberto Malovini, Aya Kitamoto, Motoji Sawabe, Tomio Arai, Yasuyuki Gondo, Martin H Steinberg, Nobuyoshi Hirose, Gil Atzmon, Gary Ruvkun, Clinton T Baldwin, Thomas T Perls
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8210 (2009)
The strong familiality of living to extreme ages suggests that human longevity is genetically regulated. The majority of genes found thus far to be associated with longevity primarily function in lipoprotein metabolism and insulin/IGF-1 signaling. Th
Externí odkaz:
https://doaj.org/article/fa7f218462b9403da2649f61a12fb2b8
Autor:
Michele M. Comerota, Manasee Gedam, Wen Xiong, Feng Jin, Lisheng Deng, Meng C. Wang, Jin Wang, Hui Zheng
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-19 (2023)
Abstract Background Age is the strongest risk factor for the development of Alzheimer’s disease (AD). Besides the pathological hallmarks of β-amyloid (Aβ) plaques and neurofibrillary tangles, emerging evidence demonstrates a critical role of micr
Externí odkaz:
https://doaj.org/article/915df7df485d404fa63a17c6ead8abed
Autor:
Manasee Gedam, Michele M. Comerota, Nicholas E. Propson, Tao Chen, Feng Jin, Meng C. Wang, Hui Zheng
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Microglia are the major cell type expressing complement C3a receptor (C3aR) in the brain. Using a knockin mouse line in which a Td-tomato reporter is incorporated into the endogenous C3ar1 locus, we identified 2 major subpopulations of microglia with
Externí odkaz:
https://doaj.org/article/81d504a6a6004f80a9955a74fb44174b
Autor:
Isaiah A. A. Neve, Jessica N. Sowa, Chih-Chun J. Lin, Priya Sivaramakrishnan, Christophe Herman, Youqiong Ye, Leng Han, Meng C. Wang
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 1, Pp 189-198 (2020)
Externí odkaz:
https://doaj.org/article/43c7d2a909784a36a923713130d35f06
Autor:
Katharina Papsdorf, Jason W. Miklas, Amir Hosseini, Matias Cabruja, Christopher S. Morrow, Marzia Savini, Yong Yu, Carlos G. Silva-García, Nicole R. Haseley, Luke Meraz Murphy, Pallas Yao, Elisa de Launoit, Scott J. Dixon, Michael P. Snyder, Meng C. Wang, William B. Mair, Anne Brunet
Publikováno v:
Nature Cell Biology. 25:672-684
Dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. But the mechanisms by which MUFAs extend lifespan remain unclear. Here we show that an organelle network involving lipid droplets and peroxisomes is critical for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d8e027898b2da2515f4ffe32358c512
https://doi.org/10.1038/s41556-023-01136-6
https://doi.org/10.1038/s41556-023-01136-6
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100170- (2020)
Summary: Glutathione (GSH) is a highly dynamic, high abundance molecule regulating redox homeostasis in most mammalian cells. Traditional methods could not achieve quantification of glutathione in live cells with high spatial and temporal resolution.
Externí odkaz:
https://doaj.org/article/4699a548b820447ebfb752e0e9b3189b
Autor:
Marzia Savini, Andrew Folick, Yi-Tang Lee, Feng Jin, André Cuevas, Matthew C. Tillman, Jonathon D. Duffy, Qian Zhao, Isaiah A. Neve, Pei-Wen Hu, Yong Yu, Qinghao Zhang, Youqiong Ye, William B. Mair, Jin Wang, Leng Han, Eric A. Ortlund, Meng C. Wang
Publikováno v:
Nature cell biology, vol 24, iss 6
Lysosomes are key cellular organelles that metabolize extra- and intracellular substrates. Alterations in lysosomal metabolism are implicated in ageing-associated metabolic and neurodegenerative diseases. However, how lysosomal metabolism actively co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a9c44c6427ca09aa20051e49ca8ee7
https://doi.org/10.1038/s41556-022-00926-8
https://doi.org/10.1038/s41556-022-00926-8