Zobrazeno 1 - 10
of 325
pro vyhledávání: '"Meng‐Qiu Dong"'
Autor:
Xiangyang Chen, Ke Wang, Farees Ud Din Mufti, Demin Xu, Chengming Zhu, Xinya Huang, Chenming Zeng, Qile Jin, Xiaona Huang, Yong-hong Yan, Meng-qiu Dong, Xuezhu Feng, Yunyu Shi, Scott Kennedy, Shouhong Guang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Germ granules are biomolecular condensates present in most animal germ cells. One function of germ granules is to help maintain germ cell totipotency by organizing mRNA regulatory machinery, including small RNA-based gene regulatory pathways
Externí odkaz:
https://doaj.org/article/e60a6a28da724963b1079731422ad276
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100553- (2024)
Multiple isozymes are encoded in the Caenorhabditis elegans genome for the various sphingolipid biosynthesis reactions, but the contributions of individual isozymes are characterized only in part. We developed a simple but effective reversed-phase li
Externí odkaz:
https://doaj.org/article/bad08cb09be6421796b57c9d3e207865
Autor:
Jin-Xin Zheng, Tong-Yang Du, Guang-Can Shao, Zhu-Hui Ma, Zhao-Di Jiang, Wen Hu, Fang Suo, Wanzhong He, Meng-Qiu Dong, Li-Lin Du
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Killer meiotic drivers (KMDs) skew allele transmission in their favor by killing meiotic progeny not inheriting the driver allele. Despite their widespread presence in eukaryotes, the molecular mechanisms behind their selfish behavior are po
Externí odkaz:
https://doaj.org/article/6f858570b0fb410981a12ca9eebe3d6e
Publikováno v:
PLoS Biology, Vol 21, Iss 12, p e3002421 (2023)
Neuronal development orchestrates the formation of an enormous number of synapses that connect the nervous system. In developing presynapses, the core active zone structure has been found to assemble through liquid-liquid phase separation. Here, we f
Externí odkaz:
https://doaj.org/article/e9a46681a4ef4f64ade5bbc93f5a73db
Autor:
Chen-Xi Zou, Zhu-Hui Ma, Zhao-Di Jiang, Zhao-Qian Pan, Dan-Dan Xu, Fang Suo, Guang-Can Shao, Meng-Qiu Dong, Li-Lin Du
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002372 (2023)
Selective macroautophagy of the endoplasmic reticulum (ER) and the nucleus, known as ER-phagy and nucleophagy, respectively, are processes whose mechanisms remain inadequately understood. Through an imaging-based screen, we find that in the fission y
Externí odkaz:
https://doaj.org/article/b96c4a34f02f423db6e3fac00e54fb51
Autor:
Yan-Ping Zhang, Wen-Hong Zhang, Pan Zhang, Qi Li, Yue Sun, Jia-Wen Wang, Shaobing O. Zhang, Tao Cai, Cheng Zhan, Meng-Qiu Dong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The role of lifespan-regulating protein expression in specific tissues in C. elegans is murky. Here, the authors provide clarity by inducible degradation of longevity-related proteins, demonstrating that intestinal DAF-2 is a major determinant of lif
Externí odkaz:
https://doaj.org/article/35e79ba0b0574bc1818d025588906364
Autor:
Lei Guan, Bin Wu, Ting Li, Lynn A. Beer, Gaurav Sharma, Mingyue Li, Chin Nien Lee, Shujing Liu, Changsong Yang, Lili Huang, Dennie T. Frederick, Genevieve M. Boland, Guangcan Shao, Tatyana M. Svitkina, Kathy Q. Cai, Fangping Chen, Meng-Qiu Dong, Gordon B. Mills, Lynn M. Schuchter, Giorgos C. Karakousis, Tara C. Mitchell, Keith T. Flaherty, David W. Speicher, Youhai H. Chen, Meenhard Herlyn, Ravi K. Amaravadi, Xiaowei Xu, Wei Guo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Lack of CD8+ T-cell infiltration into solid tumors is associated with poor responsiveness to immune checkpoint therapy (ICT). Here, the authors show that blocking the phosphorylation of HRS to reduce the induction of immunosuppressive exosomes promot
Externí odkaz:
https://doaj.org/article/718e304323ab40bb82fc54fc7895e125
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 13, Iss 4 (2023)
AbstractAbnormal nuclear morphology is suggested to be a hallmark of aging and one such abnormality is nuclear blebbing. However, little is known about whether and how nuclear blebbing participates in animal aging, and what regulates it. In this stud
Externí odkaz:
https://doaj.org/article/62db23faccaa44a49067b57c7f10c878
Autor:
Jian-Hua Wang, Yu-Liang Tang, Zhou Gong, Rohit Jain, Fan Xiao, Yu Zhou, Dan Tan, Qiang Li, Niu Huang, Shu-Qun Liu, Keqiong Ye, Chun Tang, Meng-Qiu Dong, Xiaoguang Lei
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Conformations sampled by a protein while it unfolds are difficult to visualize. Here, the authors develop di-ortho-phthalaldehyde cross-linkers for rapid chemical cross-linking mass spectrometry analysis and demonstrate that this method captures the
Externí odkaz:
https://doaj.org/article/b10d776a376f43adb33ba9a0733ab6fd
Autor:
Wen-Jun Li, Chen-Wei Wang, Li Tao, Yong-Hong Yan, Mei-Jun Zhang, Ze-Xian Liu, Yu-Xin Li, Han-Qing Zhao, Xue-Mei Li, Xian-Dong He, Yu Xue, Meng-Qiu Dong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
How phosphorylation mediated by Insulin/IGF-1 Signaling kinases regulates lifespan remains unclear. Here the authors perform a large-scale quantitative phosphoproteomic analysis of wildtype and IIS mutant C. elegans strains to reveal detailed functio
Externí odkaz:
https://doaj.org/article/79b32e5ef67f4e64b5c54680fd9b724a