Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target

Autor: Ye, S M, Huang, Y D, Mullendorff, K, Dong, L M, Giedt, G, Meng, E C, Cohen, F E, Kuntz, I D, Weisgraber, Karl H, Mahley, R W

Publikováno v: Ye, S M; Huang, Y D; Mullendorff, K; Dong, L M; Giedt, G; Meng, E C; et al.(2005). Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target. Proceedings of the National Academy of Sciences of the United States of America, 102(51), 18700-18705. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2tq6k7v4

Apolipoprotein (apo) E4 is a major risk factor for Alzheimer's disease, and many studies have suggested that apoE has isoform-specific effects on the deposition or clearance of amyloid beta (A beta) peptides. We examined the effects of apoE isoforms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::331d595a6a0334f411e08b5d6f40559b
http://www.escholarship.org/uc/item/2tq6k7v4

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Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation.

Autor: Sheikh, S P, Vilardarga, J P, Baranski, T J, Lichtarge, O, Iiri, T, Meng, E C, Nissenson, R A, Bourne, H R

Publikováno v: Journal of Biological Chemistry; June 1999, Vol. 274 Issue: 24 p17033-41, 9p

Receptor activation: what does the rhodopsin structure tell us?

Autor: Meng EC; Dept of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143-0450, USA., Bourne HR

Publikováno v: Trends in pharmacological sciences [Trends Pharmacol Sci] 2001 Nov; Vol. 22 (11), pp. 587-93.

Structure. Rhodopsin sees the light.

Autor: Bourne HR; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 94143, USA. bourne@cmp.ucsf.edu, Meng EC

Publikováno v: Science (New York, N.Y.) [Science] 2000 Aug 04; Vol. 289 (5480), pp. 733-4.