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Toward Gene Therapy for Cystic Fibrosis Using a Lentivirus Pseudotyped With Sendai Virus Envelopes

Autor: Mitomo, Katsuyuki, Griesenbach, Uta, Inoue, Makoto ^*, Somerton, Lucinda, Meng, Cuixiang, Akiba, Eiji, Tabata, Toshiaki, Ueda, Yasuji, Frankel, Gad M, Farley, Raymond, Singh, Charanjit, Chan, Mario, Munkonge, Felix, Brum, Andrea, Xenariou, Stefania, Escudero-Garcia, Sara, Hasegawa, Mamoru, Alton, Eric WFW

Publikováno v: In Molecular Therapy June 2010 18(6):1173-1182

The role of doxorubicin in non-viral gene transfer in the lung

Autor: Griesenbach, Uta, Meng, Cuixiang, Farley, Raymond, Gardner, Aaron, Brake, Maresa A., Frankel, Gad M., Gruenert, Dieter C., Cheng, Seng H., Scheule, Ronald K., Alton, Eric W.F.W.

Publikováno v: In Biomaterials 2009 30(10):1971-1977

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis

Autor: Alton, Eric WFW, Beekman, Jeffery M, Boyd, A Christopher, Brand, June, Carlon, Marianne, Connolly, Mary M, Chan, Mario, Conlon, Sinead, Davidson, Heather E, Davies, Jane C, Davies, Lee A, Dekkers, Johanna F, Doherty, Ann, Gea-Sorli, Sabrina, Gill, Deborah R, Griesenbach, Uta, Hasegawa, Mamoru, Higgins, Tracy E, Hironaka, Takashi, Hyndman, Laura, McLachlan, Gerry, Inoue, Makoto, Hyde, Stephen C, Innes, J Alastair, Maher, Toby M, Moran, Caroline, Meng, Cuixiang, Paul-Smith, Michael C, Pringle, Ian A, Pytel, Kamila M, Rodriguez-Martinez, Andrea, Schmidt, Alexander C, Stevenson, Barbara J, Sumner-Jones, Stephanie G, Toshner, Richard, Tsugumine, Shu, Wasowicz, Marguerite W, Zhu, Jie

Publikováno v: Alton, E WFW, Beekman, J M, Boyd, A C, Brand, J, Carlon, M S, Connolly, M M, Chan, M, Conlon, S, Davidson, H, Davies, J C, Davies, L A, Dekkers, J F, Doherty, A, Gea-sorli, S, Gill, D R, Griesenbach, U, Hasegawa, M, Higgins, T E, Hironaka, T, Hyndman, L, McLachlan, G, Inoue, M, Hyde, S C, Innes, J A, Maher, T M, Moran, C, Meng, C, Paul-Smith, M C, Pringle, I A, Pytel, K M, Rodriguez-Martinez, A, Schmidt, A C, Stevenson, B, Sumner-Jones, S G, Toshner, R, Tsugumine, S, Wasowicz, M W & Zhu, J 2017, ' Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis ', Thorax, vol. 72, no. 2, pp. 137-147 . https://doi.org/10.1136/thoraxjnl-2016-208406
Thorax

We have recently shown that non-viral gene therapy can stabilise the decline of lung function in patients with cystic fibrosis (CF). However, the effect was modest, and more potent gene transfer agents are still required. Fuson protein (F)/Hemaggluti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f6bf734ca182ac101485c3ece68626a2
https://ora.ox.ac.uk/objects/uuid:06e16f3b-e8eb-4ccb-b37f-5e85a5a75530

A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

Autor: Alton, Eric Wfw, Armstrong, David K, Ashby, Deborah, Bayfield, Katie J, Bilton, Diana, Bloomfield, Emily V, Boyd, A Christopher, Brand, June, Buchan, Ruaridh, Calcedo, Roberto, Carvelli, Paula, Chan, Mario, Cheng, Seng H, Collie, David S, Cunningham, Steve, Davidson, Heather E, Davies, Gwyneth, Davies, Jane C, Davies, Lee A, Dewar, Maria H, Doherty, Ann, Donovan, Jackie, Dwyer, Natalie S, Elgmati, Hala I, Featherstone, Rosanna F, Gavino, Jemyr, Gea-sorli, Sabrina, Geddes, Duncan M, Gibson, James Sr, Gill, Deborah R, Greening, Andrew P, Griesenbach, Uta, Hansell, David M, Harman, Katharine, Higgins, Tracy E, Hodges, Samantha L, Hyde, Stephen C, Hyndman, Laura, Innes, J Alastair, Jacob, Joseph, Jones, Nancy, Keogh, Brian F, Limberis, Maria P, Lloyd-evans, Paul, Maclean, Alan W, Manvell, Michelle C, Mccormick, Dominique, Mcgovern, Michael, Mclachlan, Gerry, Meng, Cuixiang, Montero, M Angeles, Milligan, Hazel, Moyce, Laura J, Murray, Gordon D, Nicholson, Andrew G, Osadolor, Tina, Parra-leiton, Javier, Porteous, David J, Pringle, Ian A, Punch, Emma K, Pytel, Kamila M, Quittner, Alexandra L, Rivellini, Gina, Saunders, Clare J, Scheule, Ronald K, Sheard, Sarah, Simmonds, Nicholas J, Smith, Keith, Smith, Stephen N, Soussi, Najwa, Soussi, Samia, Spearing, Emma J, Stevenson, Barbara J, Sumner-jones, Stephanie G, Turkkila, Minna, Ureta, Rosa P, Waller, Michael D, Wasowicz, Marguerite Y, Wilson, James M, Wolstenholme-hogg, Paul

Publikováno v: Alton, E W, Armstrong, D K, Ashby, D, Bayfield, K J, Bilton, D, Bloomfield, E V, Boyd, A C, Brand, J, Buchan, R, Calcedo, R, Carvelli, P, Chan, M, Cheng, S H, Collie, D S, Cunningham, S, Davidson, H E, Davies, G, Davies, J C, Davies, L A, Dewar, M H, Doherty, A, Donovan, J, Dwyer, N S, Elgmati, H I, Featherstone, R F, Gavino, J, Gea-sorli, S, Geddes, D M, Gibson, J S, Gill, D R, Greening, A P, Griesenbach, U, Hansell, D M, Harman, K, Higgins, T E, Hodges, S L, Hyde, S C, Hyndman, L, Innes, J A, Jacob, J, Jones, N, Keogh, B F, Limberis, M P, Lloyd-evans, P, Maclean, A W, Manvell, M C, Mccormick, D, Mcgovern, M, Mclachlan, G, Meng, C, Montero, M A, Milligan, H, Moyce, L J, Murray, G D, Nicholson, A G, Osadolor, T, Parra-leiton, J, Porteous, D J, Pringle, I A, Punch, E K, Pytel, K M, Quittner, A L, Rivellini, G, Saunders, C J, Scheule, R K, Sheard, S, Simmonds, N J, Smith, K, Smith, S N, Soussi, N, Soussi, S, Spearing, E J, Stevenson, B J, Sumner-jones, S G, Turkkila, M, Ureta, R P, Waller, M D, Wasowicz, M Y, Wilson, J M & Wolstenholme-hogg, P 2016, A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis . Efficacy and Mechanism Evaluation, no. 5, vol. 3, vol. 3 . https://doi.org/10.3310/eme03050

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::652d7f6547305ca5fd120989d6732d40
https://hdl.handle.net/20.500.11820/6cbd29f1-9d74-4a71-a11a-6d87edad87e6