Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Menelas N Pangalos"'
Autor:
Julie A. Douthwaite, Christopher A. Brown, John R. Ferdinand, Rahul Sharma, Jane Elliott, Molly A. Taylor, Nancy T. Malintan, Hannah Duvoisin, Thomas Hill, Oona Delpuech, Alexandra L. Orton, Haidee Pitt, Fred Kuenzi, Simon Fish, David J. Nicholls, Anna Cuthbert, Ian Richards, Giles Ratcliffe, Abhishek Upadhyay, Abigail Marklew, Craig Hewitt, Douglas Ross-Thriepland, Christopher Brankin, Matthieu Chodorge, Gareth Browne, Palwinder K. Mander, Ruud M. DeWildt, Shane Weaver, Penny A. Smee, Joost van Kempen, Jon G. Bartlett, Paula M. Allen, Emma L. Koppe, Charlotte A. Ashby, Julian D. Phipps, Nalini Mehta, David J. Brierley, David G. Tew, Melanie V. Leveridge, Stuart M. Baddeley, Ian G. Goodfellow, Clive Green, Chris Abell, Andy Neely, Ian Waddell, Steve Rees, Patrick H. Maxwell, Menelas N. Pangalos, Rob Howes, Roger Clark
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract On 11th March 2020, the UK government announced plans for the scaling of COVID-19 testing, and on 27th March 2020 it was announced that a new alliance of private sector and academic collaborative laboratories were being created to generate t
Externí odkaz:
https://doaj.org/article/b16f2bbb322448d5a5973467180ddaa4
Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting
Autor:
Vesa Anttila, Antti Saraste, Juhani Knuuti, Marja Hedman, Pekka Jaakkola, Karl-Ludwig Laugwitz, Markus Krane, Anders Jeppsson, Saara Sillanmäki, Jaya Rosenmeier, Pernilla Zingmark, Anna Rudvik, Pavlo Garkaviy, Christina Watson, Menelas N. Pangalos, Kenneth R. Chien, Regina Fritsche-Danielson, Anna Collén, Li-Ming Gan
Publikováno v:
Molecular Therapy. 31:866-874
Vascular endothelial growth factor A (VEGF-A) has therapeutic cardiovascular effects but delivery challenges have impeded clinical development. We report the first clinical study of naked mRNA encoding VEGF-A (AZD8601) injected into the human heart.
Autor:
Abhishek Nag, Ryan S. Dhindsa, Jonathan Mitchell, Chirag Vasavda, Andrew R. Harper, Dimitrios Vitsios, Andrea Ahnmark, Bilada Bilican, Katja Madeyski-Bengtson, Bader Zarrouki, Anthony W. Zoghbi, Quanli Wang, Katherine R. Smith, Jesus Alegre-Díaz, Pablo Kuri-Morales, Jaime Berumen, Roberto Tapia-Conyer, Jonathan Emberson, Jason M. Torres, Rory Collins, David M. Smith, Benjamin Challis, Dirk S. Paul, Mohammad Bohlooly-Y, Mike Snowden, David Baker, Regina Fritsche-Danielson, Menelas N. Pangalos, Slavé Petrovski
We performed collapsing analyses on 454,796 UK Biobank (UKB) exomes to detect gene-level associations with diabetes. Recessive carriers of nonsynonymous variants in MAP3K15 were 30% less likely to develop diabetes ( P = 5.7 × 10 −10 ) and had lowe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a682c76a1eca49d8219fc25c810730
https://doi.org/10.1126/sciadv.add5430
https://doi.org/10.1126/sciadv.add5430
Autor:
Abhishek, Nag, Ryan S, Dhindsa, Jonathan, Mitchell, Chirag, Vasavda, Andrew R, Harper, Dimitrios, Vitsios, Andrea, Ahnmark, Bilada, Bilican, Katja, Madeyski-Bengtson, Bader, Zarrouki, Anthony W, Zoghbi, Quanli, Wang, Katherine R, Smith, Jesus, Alegre-Díaz, Pablo, Kuri-Morales, Jaime, Berumen, Roberto, Tapia-Conyer, Jonathan, Emberson, Jason M, Torres, Rory, Collins, David M, Smith, Benjamin, Challis, Dirk S, Paul, Mohammad, Bohlooly-Y, Mike, Snowden, David, Baker, Regina, Fritsche-Danielson, Menelas N, Pangalos, Slavé, Petrovski
Publikováno v:
Science advances. 8(46)
We performed collapsing analyses on 454,796 UK Biobank (UKB) exomes to detect gene-level associations with diabetes. Recessive carriers of nonsynonymous variants in
Autor:
Jacqueline P. Robbins, Leo Perfect, Elena M. Ribe, Marcello Maresca, Adrià Dangla-Valls, Evangeline M. Foster, Richard Killick, Paulina Nowosiad, Matthew J. Reid, Lucia Dutan Polit, Alejo J. Nevado, Daniel Ebner, Mohammad Bohlooly-Y, Noel Buckley, Menelas N. Pangalos, Jack Price, Simon Lovestone
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Our understanding of the molecular processes underlying Alzheimer’s disease (AD) is still limited, hindering the development of effective treatments, and highlighting the need for human-specific models. Advances in identifying components of the amy
Externí odkaz:
https://doaj.org/article/cbd88ea3b15f4424a992edf8c0d98186
Autor:
Hugh Montgomery, F D Richard Hobbs, Francisco Padilla, Douglas Arbetter, Alison Templeton, Seth Seegobin, Kenneth Kim, Jesus Abraham Simón Campos, Rosalinda H Arends, Bryan H Brodek, Dennis Brooks, Pedro Garbes, Julieta Jimenez, Gavin C K W Koh, Kelly W Padilla, Katie Streicher, Rolando M Viani, Vijay Alagappan, Menelas N Pangalos, Mark T Esser, Wakana Abe, Tania Adan De Varona, Daria Adiatullina, Daniel Aguilar Zapata, Kevin Ahlers, Carolina Aimo, Ayoade Akere, Elena Akimova, Jorge Alatorre Alexander, Logan Aldrich, Ismael Ali Garcia, Karim Ali García, Lee Allison, Rosa Alonso Zuñiga, Ivan Aloysius, Javier Altclas, Andres Alvarisqueta, Martti Antila, Camila Anton, Elisabet Árboix Alamo, Samir Arora, Ramón Alejandro Avilés Felix, Natalya Bakhtina, Varenka Barbero-Becerra, Armando Barragan-Reyes, Alejandro Barreira, Mitchell Barrett, Jiri Beran, Nikolett Berki, Viktoria Berki, Richard Betten, Claudia Binelli, Lenka Brunzová, Cecilia Bussolari, Karianna Byargeon, Justyna Bytnar, Carlos Camberos, Pedro Campos Corzo, Grazia Cannon, Valentina Canovi, Simone Carla da Rosa, Ana Caroline Moser, Luis Carrera Rivas, Marcelo Martin Casas, Paulo Castañeda-Méndez, Ana Cavalcante, Eugenia Cherepova, Alexei Chermenskii, Lauren Clark, Mauro Codeluppi, Flavia Coelho, Belinda Contreras, Alex Cran, Taylor Dao, Chrisette Dharma, Cosimo Di Castri, Victoria Diaz Balocchi, Omar Durán, Kara Earl, Adam Ellery, Tomoko Endo, Andrea Everding, Rainald Fischer, Benedito Fonseca, Chelsea C. Franklin, Susan-Beatrice Franz, Anna Fumagalli, Mauricio Galindo-Amaya, Mariagiulia Galli, Laura Gerna, Karolly Gil Ureña, Henrikki Gomes Antila, Laura Ines Gomes Maricato, Gabriela Goncalvez, Martin Gonzalez, Jesús González-Lama, Stephen Granier, Jacob Granier, Stephan Grunwald, David Guardeño-Ropero, Monica Guberti, Sridhar Guduri, Carolina Guerrero García, Jehad Haggiagi, Kacie Hale, Toshimasa Hayashi, Maiara Hermes, Dante Hernandez Colin, Yuji Hirai, Masayuki Hojo, Tetsuya Homma, Billy Hour, Andreas Huber, Diego Iacovelli, Noriomi Ishibashi, Yutaro Iwabe, Shinyu Izumi, Arne Jessen, Heiko Jessen, Wilner Jeudy, Marta Jiménez Marcos, Rebecca Johnson, Eva Juárez-Hernández, Kiyomi Kabasawa, Katarzyna Kamińska, Megumi Kawabe, Angela Kemp, Oleg Khmelnitskiy, Carina Klassen, Olena Kobrynska, Pavel Koleckar, Stephanie Korn, Marc Kornmann, Viktor Kostenko, Evgenii Kovalchuk, Yana Kovalchuk, Tim Kümmerle, Ulrike Lachmund, Kerstin Lammersmann, Flávio Lastebasse, Ivana Lattuada, Felicitas Lauer, Kyrylo Lebed, Olga Lebed, Diego Lecona-Garcia, Maria Christina Leoni, Marina Lima, Raymond Little, Holly Little, Andrea Lizardi-Díaz, Michele Lobo-Becker, Francesco Luppi, Veronica Macias, Shigefumi Maesaki, Cristiano Magnaghi, Annalisa Mancini, Stanisław Mazur, Tatiana Melnikova, Sergio Menchaca, Ibrahim Menendez-Perez, Ewa Międlar, Shuuichi Mizunuma, Anastasiya Mochalova, Mihad Mohamed, Theresa Moll, Camila Montalvo, Amber Mottola, Birgit Mück, Rebeca Mussi Brugnolli, Akanksha Nanda, Dörthe Neuner, Agatha Ngwueke, Sebastian Noe, Martin Novacek, Laura Nuzzolo-Shihadeh, Emeka Obiekwe, Isaias G. Ocampo Gaytán, Norio Ohmagari, Shin Ohta, Ptuonye Onyewuchi, Iurii Pankov, Maurício Pedrosa, Yael Peré, Alejandro Pereyra, Eliana Perez, Eduardo Perez-Alba, Paloma Perpiña Lozano, Tanya Perrei, Dena Peterson, Ligia Pierroti, Felipe Pineda-Cárdenas, Teresa Plascencia Sanchez, Camila Poletti, Chiara Pomaranzi, Lisette Portes, Nils Postel, Monica Ramirez, Isabel Ramírez, Miguel Ramirez-Baena, Mahadev Ramjee, Giovanna Ratti, Jackie Reeve, Petr Reichert, Petra Reichertová, Edgar Alejandro Reyes Garcia, Celso Ricardo, Nicomedes Rodríguez Rodríguez, Jaun Roldán Sánchez, Matilde Romero-Lopez, Tyrone Rosales, Harvey Rosales, Mohamed Roshan, Simran Roshan, Patrizia Rovere Querini, Heather Rutter, Sadaf Sachwani, Hironori Sagara, Jun Sakai, Nina Samson, José Héctor Sánchez Mijangos, Liliana Sánchez, Ana Sánchez-González, Micko Sandford, Laura Santana, Felipe Santos de Carvalho, Reiko Sasao, Lubna Sato, Elizabeth Scheuermann, Olaf Schmidt, Masafumi Seki, Safia Shaikh, Daishi Shimada, Masaharu Shinkai, Masahiro Shinoda, Jackie Smith, Fernando Solorzano, Silvia Soncini, Katalin Soregine, Erica Sosa, Olalekan Sowade, Veronika Špinková, Ruth Staniford, Iska Steigemann, Vivien Steiner, Vladimir Strelkov, Cintya R. Suárez Pineda, Hiroki Suenaga, Shintaro Suzaki, Hannah Swayze, Yuji Tada, Yuichiro Takeshita, Yasuo Takiguchi, Akihiko Tanaka, Norihito Tarumoto, Albina Tatarintseva, Michelle Taubert, Elizaveta Terenya, César Tinoco, Tomohiro Tomiyasu, Gladys Torres-Vidal, Gabriela Trejo-Aguiar, Kenji Tsushima, Emma Tunstall, Caterina Turrà, Yoandy Valdes, Nelly Valencia Castro, Guilherme Visconti, Giordano Vitali, Apinya Vutikullird, Jezdancher Watti, Doreen Werth, Cheyanne Wilson, Philippe Wilson, Amy Workman, Pamela Wörle, Christoph Wyen, Yoshiko Yamaguchi, Kei Yamamoto
Background: Early intramuscular administration of SARS-CoV-2-neutralising monoclonal antibody combination, tixagevimab–cilgavimab, to non-hospitalised adults with mild to moderate COVID-19 has potential to prevent disease progression. We aimed to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94fa5ffbc73770cc232f4cba4d22465
https://ora.ox.ac.uk/objects/uuid:a692f8eb-aeed-49a1-a1a8-3275e433517b
https://ora.ox.ac.uk/objects/uuid:a692f8eb-aeed-49a1-a1a8-3275e433517b
Autor:
Myron J, Levin, Andrew, Ustianowski, Steven, Thomas, Alison, Templeton, Yuan, Yuan, Seth, Seegobin, Catherine F, Houlihan, Ibrahim, Menendez-Perez, Simon, Pollett, Rosalinda H, Arends, Rohini, Beavon, Kanika, Dey, Pedro, Garbes, Elizabeth J, Kelly, Gavin C K W, Koh, Stefan, Ivanov, Karen A, Near, Audrey, Sharbaugh, Katie, Streicher, Menelas N, Pangalos, Mark T, Esser
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
We report primary results of a phase 3 trial of AZD7442 (tixagevimab/cilgavimab) for post-exposure prophylaxis to prevent symptomatic coronavirus disease 2019 (COVID-19).Adults without prior SARS-CoV-2 infection or COVID-19 vaccination were enrolled
Autor:
Myron J, Levin, Andrew, Ustianowski, Stéphane, De Wit, Odile, Launay, Miles, Avila, Alison, Templeton, Yuan, Yuan, Seth, Seegobin, Adam, Ellery, Dennis J, Levinson, Philip, Ambery, Rosalinda H, Arends, Rohini, Beavon, Kanika, Dey, Pedro, Garbes, Elizabeth J, Kelly, Gavin C K W, Koh, Karen A, Near, Kelly W, Padilla, Konstantina, Psachoulia, Audrey, Sharbaugh, Katie, Streicher, Menelas N, Pangalos, Mark T, Esser, Michelle, Owens
Publikováno v:
The New England journal of medicine. 386(23)
The monoclonal-antibody combination AZD7442 is composed of tixagevimab and cilgavimab, two neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that have an extended half-life and have been shown to have prophy
Autor:
Shari Wiseman, Tarek G. Deeb, Menelas N. Pangalos, Angus C. Nairn, Paul A. Slesinger, Xiaofan Li, Miho Terunuma, Stephen J. Moss
Publikováno v:
The Journal of Neuroscience. 40:2808-2816
Addictive drugs usurp the brain's intrinsic mechanism for reward, leading to compulsive and destructive behaviors. In the ventral tegmental area (VTA), the center of the brain's reward circuit, GABAergic neurons control the excitability of dopamine (
Autor:
Benjamin Challis, Andrew R. Harper, David J. Smith, Menelas N. Pangalos, Mohammad Bohlooly-Y, Katherine R. Smith, Bader Zarrouki, Katja Madeyski-Bengtson, Dirk S. Paul, David Baker, Bilada Bilican, Andrea Ahnmark, Dimitrios Vitsios, Abhishek Nag, Mike Snowden, Regina Fritsche-Danielson, Quanli Wang, Ryan S. Dhindsa, Slavé Petrovski
Diabetes mellitus is a chronic health condition that can result in significant end-organ complications and is estimated to impact at least 8.5% of the global adult population. Here, we performed gene-level collapsing analysis on exome sequences from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0674becf0ec3222eca26279fed3d6ee
https://doi.org/10.1101/2021.11.14.21266328
https://doi.org/10.1101/2021.11.14.21266328