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H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Pediatric High-Grade Gliomas.

Autor: Garcia-Fabiani MB; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Current address: Leloir Institute Foundation, Buenos Aires, Argentina., Haase S; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Banerjee K; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., McClellan B; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Zhu Z; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Mujeeb A; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Li Y; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Yu J; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Current address: Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Kadiyala P; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Taher A; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Núñez FJ; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Alghamri MS; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Comba A; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Mendez FM; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Nicola Candia AJ; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Salazar B; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Cancer Biology Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA., Koschmann C; Department of Pediatrics, Chad Carr Pediatric Brain Tumor Center, University of Michigan Medical School, MI 48109, USA., Nunez FM; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Edwards M; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Qin T; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Sartor MA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Lowenstein PR; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Bioengineering, University of Michigan, Ann Arbor, MI 48109, USA., Castro MG; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 13. Date of Electronic Publication: 2023 Jun 13.

Immune-stimulatory (TK/Flt3L) gene therapy opens the door to a promising new treatment strategy against brainstem gliomas.

Autor: Faisal SM; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Mendez FM; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Nunez F; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Castro MG; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Lowenstein PR; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Publikováno v: Oncotarget [Oncotarget] 2020 Dec 15; Vol. 11 (50), pp. 4607-4612. Date of Electronic Publication: 2020 Dec 15 (Print Publication: 2020).

Enzyme replacement therapy interruption in patients with Mucopolysaccharidoses: Recommendations for distinct scenarios in Latin America.

Autor: Solano M; Fundacion Cardioinfantil de Bogota, Colombia., Fainboim A; Polivalent Day Hospital, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina., Politei J; Laboratorio de Neuroquímica Dr. N. A. Chamoles, Fundación para el Estudio de Enfermedades Neurometabólicas (FESEN), Buenos Aires, Argentina., Porras-Hurtado GL; Clinica Comfamiliar Risaralda, Colombia., Martins AM; Reference Center of Metabolic Inborn Errors, Universidade Federal de São Paulo, São Paulo, Brazil., Souza CFM; Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Koch FM; Pediatric Neurology, Puerto Montt Hospital, Chile., Amartino H; Servicio de Neurología Infantil y Clinica de Mucopolisacaridosis y transtornos relacionados, Hospital Universitario Austral, Buenos Aires, Argentina., Satizábal JM; Department of Physiological Sciences, School of Basic Sciences, Faculty of Health, Universidad del Valle, Cali, Colombia., Horovitz DDG; Medical Genetics Department, National Institute of Women, Children and Adolescents Health Fernandes Figueira/Fiocruz, Rio de Janeiro, Brazil., Medeiros PFV; Unidade Acadêmica de Medicina, Hospital Universitário Alcides Carneiro, Universidade Federal de Campina Grande, Brazil., Honjo RS; Genetics Unit, Instituto da Criança do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., Lourenço CM; Faculdade de Medicina, Centro Universitario Estácio de Ribeirão Preto, Ribeirão Preto, Brazil.

Publikováno v: Molecular genetics and metabolism reports [Mol Genet Metab Rep] 2020 Feb 27; Vol. 23, pp. 100572. Date of Electronic Publication: 2020 Feb 27 (Print Publication: 2020).

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response.

Autor: Núñez FJ; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Mendez FM; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Kadiyala P; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Alghamri MS; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Savelieff MG; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Garcia-Fabiani MB; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Haase S; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Koschmann C; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Calinescu AA; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Kamran N; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Saxena M; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Patel R; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Carney S; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Guo MZ; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Edwards M; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Ljungman M; Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Environmental Health Science, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA., Qin T; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Sartor MA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Tagett R; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Venneti S; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Brosnan-Cashman J; Departments of Pathology, Oncology and Urology, Johns Hopkins University, Baltimore, MD 21287, USA., Meeker A; Departments of Pathology, Oncology and Urology, Johns Hopkins University, Baltimore, MD 21287, USA., Gorbunova V; Department of Biology, University of Rochester, Rochester, NY 14627, USA., Zhao L; Department of Biostatistics, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Kremer DM; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.; Graduate Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA., Zhang L; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA., Lyssiotis CA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA., Jones L; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA., Herting CJ; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30322, USA.; Graduate Division of Molecular and Systems Pharmacology, Emory University, Atlanta, GA 30322, USA., Ross JL; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30322, USA.; Graduate Division of Cancer Biology, Emory University, Atlanta, GA 30322, USA., Hambardzumyan D; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30322, USA., Hervey-Jumper S; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Figueroa ME; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136-1000, USA., Lowenstein PR; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA. mariacas@med.umich.edu pedrol@med.umich.edu.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Castro MG; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA. mariacas@med.umich.edu pedrol@med.umich.edu.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2019 Feb 13; Vol. 11 (479).