Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.

Autor: Salvador JAR; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal; Center for Neuroscience and Cell Biology, Coimbra, Portugal. Electronic address: salvador@ci.uc.pt., Leal AS; Michigan State University, Department of Pharmacology and Toxicology, Life Science Building 1355, Bogue St Room 430, USA., Valdeira AS; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal; Center for Neuroscience and Cell Biology, Coimbra, Portugal., Gonçalves BMF; Center for Neuroscience and Cell Biology, Coimbra, Portugal; CHEM4PHARMA, Biocant - Parque Tecnológico de Cantanhede, Núcleo 4, Lote 14, 3060-197, Cantanhede, Portugal., Alho DPS; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal; Center for Neuroscience and Cell Biology, Coimbra, Portugal., Figueiredo SAC; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal; Center for Neuroscience and Cell Biology, Coimbra, Portugal., Silvestre SM; Center for Neuroscience and Cell Biology, Coimbra, Portugal; CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal., Mendes VIS; Center for Neuroscience and Cell Biology, Coimbra, Portugal; CHEM4PHARMA, Biocant - Parque Tecnológico de Cantanhede, Núcleo 4, Lote 14, 3060-197, Cantanhede, Portugal.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2017 Dec 15; Vol. 142, pp. 95-130. Date of Electronic Publication: 2017 Jul 14.

Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells.

Autor: Mendes VIS; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548, Coimbra, Portugal; Center for Neuroscience and Cell Biology, Coimbra, Portugal., Bartholomeusz GA; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ayres M; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gandhi V; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: vgandhi@mdanderson.org., Salvador JAR; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548, Coimbra, Portugal; Center for Neuroscience and Cell Biology, Coimbra, Portugal. Electronic address: salvador@ci.uc.pt.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2016 Nov 10; Vol. 123, pp. 317-331. Date of Electronic Publication: 2016 Jul 22.