Zobrazeno 1 - 10
of 811
pro vyhledávání: '"Menden, P."'
We establish empirical risk minimization principles for active learning by deriving a family of upper bounds on the generalization error. Aligning with empirical observations, the bounds suggest that superior query algorithms can be obtained by combi
Externí odkaz:
http://arxiv.org/abs/2409.09078
Autor:
Pierre Marrec, Susanne Menden‐Deuer
Publikováno v:
Limnology and Oceanography Letters, Vol 9, Iss 5, Pp 624-633 (2024)
Abstract Microzooplankton grazing is an essential parameter to predict the fate of organic matter production in planktonic food webs. To identify predictors of grazing, we leveraged a 6‐yr time series of coastal plankton growth and grazing rates ac
Externí odkaz:
https://doaj.org/article/6c2ff2bb3c484524af5ea7c93132b598
Autor:
Juliane Tschuck, Vidya Padmanabhan Nair, Ana Galhoz, Carole Zaratiegui, Hin-Man Tai, Gabriele Ciceri, Ina Rothenaigner, Jason Tchieu, Brent R. Stockwell, Lorenz Studer, Daphne S. Cabianca, Michael P. Menden, Michelle Vincendeau, Kamyar Hadian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The development of functional neurons is a complex orchestration of multiple signaling pathways controlling cell proliferation and differentiation. Because the balance of antioxidants is important for neuronal survival and development, we hy
Externí odkaz:
https://doaj.org/article/444c8caf5d9e4924ae0ce2d1e59fd94d
Autor:
Irineos Papakyriacou, Ginte Kutkaite, Marta Rúbies Bedós, Divya Nagarajan, Liam P. Alford, Michael P. Menden, Yumeng Mao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Immune checkpoint blockade therapy aims to activate the immune system to eliminate cancer cells. However, clinical benefits are only recorded in a subset of patients. Here, we leverage genome-wide CRISPR/Cas9 screens in a Tumor-Immune co-Cul
Externí odkaz:
https://doaj.org/article/b4b21ac099f0476298aa50b1eda1257e
Autor:
Olaf Riess, Marc Sturm, Benita Menden, Alexandra Liebmann, German Demidov, Dennis Witt, Nicolas Casadei, Jakob Admard, Leon Schütz, Stephan Ossowski, Stacie Taylor, Sven Schaffer, Christopher Schroeder, Andreas Dufke, Tobias Haack
Publikováno v:
npj Genomic Medicine, Vol 9, Iss 1, Pp 1-10 (2024)
Abstract In the era of precision medicine, genome sequencing (GS) has become more affordable and the importance of genomics and multi-omics in clinical care is increasingly being recognized. However, how to scale and effectively implement GS on an in
Externí odkaz:
https://doaj.org/article/cb6dc089453740c187c43de73a2285ff
Autor:
S. A. Castillo Cieza, R. H. R. Stanley, P. Marrec, D. N. Fontaine, E. T. Crockford, D. J. McGillicuddy Jr., A. Mehta, S. Menden-Deuer, E. E. Peacock, T. A. Rynearson, Z. O. Sandwith, W. Zhang, H. M. Sosik
Publikováno v:
Biogeosciences, Vol 21, Pp 1235-1257 (2024)
Because of its temperate location, high dynamic range of environmental conditions, and extensive human activity, the long-term ecological research site in the coastal Northeastern US Shelf (NES) of the northwestern Atlantic Ocean offers an ideal oppo
Externí odkaz:
https://doaj.org/article/04e0fd532d58495c84307338cecfeca6
Autor:
Eric S. Geanes, Rebecca McLennan, Stephen H. Pierce, Heather L. Menden, Oishi Paul, Venkatesh Sampath, Todd Bradley
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109975- (2024)
Summary: Severe COVID-19 often leads to secondary infections and sepsis that contribute to long hospital stays and mortality. However, our understanding of the precise immune mechanisms driving severe complications after SARS-CoV-2 infection remains
Externí odkaz:
https://doaj.org/article/66359978581b4fd894b7c2cfb051929c
Autor:
Kevin Menden, Margherita Francescatto, Tenzin Nyima, Cornelis Blauwendraat, Ashutosh Dhingra, Melissa Castillo-Lizardo, Noémia Fernandes, Lalit Kaurani, Deborah Kronenberg-Versteeg, Burcu Atasu, Eldem Sadikoglou, Barbara Borroni, Salvador Rodriguez-Nieto, Javier Simon-Sanchez, Andre Fischer, David Wesley Craig, Manuela Neumann, Stefan Bonn, Patrizia Rizzu, Peter Heutink
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-8 (2023)
Abstract Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are curre
Externí odkaz:
https://doaj.org/article/88edd2738c9d48e8ab92b285970b6bb0
Autor:
Alexander J. Ohnmacht, Arndt Stahler, Sebastian Stintzing, Dominik P. Modest, Julian W. Holch, C. Benedikt Westphalen, Linus Hölzel, Marisa K. Schübel, Ana Galhoz, Ali Farnoud, Minhaz Ud-Dean, Ursula Vehling-Kaiser, Thomas Decker, Markus Moehler, Matthias Heinig, Volker Heinemann, Michael P. Menden
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Precision medicine has revolutionised cancer treatments; however, actionable biomarkers remain scarce. To address this, we develop the Oncology Biomarker Discovery (OncoBird) framework for analysing the molecular and biomarker landscape of r
Externí odkaz:
https://doaj.org/article/6154ff20ebe74724a6a6c7ebb50722a3
Autor:
Heumos, Lukas, Ehmele, Philipp, Cuellar, Luis Kuhn, Menden, Kevin, Miller, Edmund, Lemke, Steffen, Gabernet, Gisela, Nahnsen, Sven
Machine learning has shown extensive growth in recent years and is now routinely applied to sensitive areas. To allow appropriate verification of predictive models before deployment, models must be deterministic. However, major machine learning libra
Externí odkaz:
http://arxiv.org/abs/2104.07651