Zobrazeno 1 - 10
of 1 383
pro vyhledávání: '"Mendelian Randomisation"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Prior research has identified associations between immune cells and aplastic anaemia (AA); however, the causal relationships between them have not been conclusively established. A two-sample Mendelian randomisation analysis was conducted to
Externí odkaz:
https://doaj.org/article/5e169c8032a74f31b8954b88d7e52d5e
Autor:
Zhongyuan Bai, Jiawei Hao, Miaoran Chen, Kaixin Yao, Leilei Zheng, Liu Liu, Jingxi Hu, Kaiqing Guo, Yongqiang Lv, Feng Li
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Inflammatory bowel disease (IBD) is a chronic disease that includes Crohn’s disease (CD) and ulcerative colitis (UC). Although genome-wide association studies (GWASs) have identified many relevant genetic risk loci, the impact of these loc
Externí odkaz:
https://doaj.org/article/1b7282519a0041b8a641d24c720eeffb
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-11 (2024)
Abstract Background We aimed to explore the association and potential causality between polyunsaturated fatty acids concentrations and the risk of periodontal disease. Materials and methods Data were collected from the 2011–2014 National Health and
Externí odkaz:
https://doaj.org/article/f8e5d2c661e246aeb9798b8cb1d15c5a
Autor:
Xin Li, Jiang-Shan Tan, Jing Xu, Zhihui Zhao, Qing Zhao, Yi Zhang, Anqi Duan, Zhihua Huang, Sicheng Zhang, Luyang Gao, Yue Jin Yang, Tao Yang, Qi Jin, Qin Luo, Yanmin Yang, Zhihong Liu
Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Patients with pulmonary arterial hypertension (PAH) exhibit a distinct gut microbiota profile; however, the causal association between gut microbiota, associated metabolites, and PAH remains elusive. We aimed to investigate this c
Externí odkaz:
https://doaj.org/article/9aa62a0517354f45834e5d84f774b8ac
Autor:
Adrian Dahl Askelund, Robyn E. Wootton, Fartein A. Torvik, Rebecca B. Lawn, Helga Ask, Elizabeth C. Corfield, Maria C. Magnus, Ted Reichborn-Kjennerud, Per M. Magnus, Ole A. Andreassen, Camilla Stoltenberg, George Davey Smith, Neil M. Davies, Alexandra Havdahl, Laurie J. Hannigan
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-27 (2024)
Abstract Background The timing of puberty may have an important impact on adolescent mental health. In particular, earlier age at menarche has been associated with elevated rates of depression in adolescents. Previous research suggests that this rela
Externí odkaz:
https://doaj.org/article/29d3f4adc7b245f58693f6795fcdf5dd
Publikováno v:
The Journal of Clinical Hypertension, Vol 26, Iss 4, Pp 382-390 (2024)
Abstract It has been suggested that Omega‐3 fatty acids may improve endothelial thickness and thereby reduce the onset of cardiovascular diseases such as coronary atherosclerosis and hypertension. However, published observational epidemiological st
Externí odkaz:
https://doaj.org/article/9c2b87681e4d4af4bdee3f871eb781b1
Autor:
Heba Alwan, Jian'an Luan, Alice Williamson, Julia Carrasco-Zanini, Isobel D. Stewart, Nicholas J. Wareham, Claudia Langenberg, Maik Pietzner
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105306- (2024)
Summary: Background: Variation in thyroid function parameters within the normal range has been observationally associated with adverse health outcomes. Whether those associations reflect causal effects is largely unknown. Methods: We systematically t
Externí odkaz:
https://doaj.org/article/04442198906241d39b35ff64d8cfb475
Autor:
Haibing Xiong, Ran Jiang, Lingzhi Xing, Jiaojiao Zheng, Xinhong Tian, Jiajie Leng, Xin Guo, Shi Zeng, Haofeng Xiong, Jianhong Huo, Letai Li
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundPrevious observational clinical studies and meta-analyses have yielded inconsistent results regarding the relationship between vitamin D and headache, and the causal relationship remains unclear. The aim of this study was to investigate the
Externí odkaz:
https://doaj.org/article/c129bdc366af4e29946ca9e45b2828d7
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe gut microbiota significantly influences the onset and progression of juvenile idiopathic arthritis (JIA) and associated uveitis (JIAU); however, the causality remains unclear. This study aims to establish a causal link between gut micro
Externí odkaz:
https://doaj.org/article/8b99fc411ac14758820102ef735710df
Autor:
Yaodong Sun, Dongdong Du, Jiantao Zhang, Linlin Zhao, Bufan Zhang, Yi Zhang, Tianxu Song, Naishi Wu
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundThis Mendelian randomization (MR) study aimed to explore the causal relationship between the genetic predisposition to type 2 diabetes mellitus (T2DM) and aortic dissection (AD), and to assess associations with genetically predicted glycemi
Externí odkaz:
https://doaj.org/article/8899d06f260e42a49750e868aa94ee19