Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Menachem J, Gunzburg"'
Autor:
Mahta Mansouri, Shawn Rumrill, Shane Dawson, Adam Johnson, Jo-Anne Pinson, Menachem J. Gunzburg, Catherine F. Latham, Nicholas Barlow, George W. Mbogo, Paula Ellenberg, Stephen J. Headey, Nicolas Sluis-Cremer, David Tyssen, Joseph D. Bauman, Francesc X. Ruiz, Eddy Arnold, David K. Chalmers, Gilda Tachedjian
Publikováno v:
Molecules, Vol 28, Iss 7, p 3103 (2023)
Human immunodeficiency virus type I (HIV-1) is a retrovirus that infects cells of the host’s immune system leading to acquired immunodeficiency syndrome and potentially death. Although treatments are available to prevent its progression, HIV-1 rema
Externí odkaz:
https://doaj.org/article/c7cd4c19945d4662b4ccbad1fae4b33e
Autor:
Luke A. Adams, Lorna E. Wilkinson-White, Menachem J. Gunzburg, Stephen J. Headey, Biswaranjan Mohanty, Martin J. Scanlon, Ben Capuano, Joel P. Mackay, Bradley C. Doak
Publikováno v:
Journal of Medicinal Chemistry. 66:5859-5872
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de010768ec5512cd1a8a32538465d72f
https://doi.org/10.1021/acs.jmedchem.3c00137
https://doi.org/10.1021/acs.jmedchem.3c00137
Autor:
Adam J. Vogrin, Neil I. Bower, Menachem J. Gunzburg, Sally Roufail, Kazuhide S. Okuda, Scott Paterson, Stephen J. Headey, Steven A. Stacker, Benjamin M. Hogan, Marc G. Achen
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2023-2036.e4 (2019)
Summary: Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. In diverse vertebrate organs, lymphatic vessels display organotypic function and develop in an organ-specific manner. In all sett
Externí odkaz:
https://doaj.org/article/4ff63854e2ad428099b435bfa53eb1db
Autor:
Gregory M Davis, Shikui Tu, Joshua WT Anderson, Rhys N Colson, Menachem J Gunzburg, Michelle A Francisco, Debashish Ray, Sean P Shrubsole, Julia A Sobotka, Uri Seroussi, Robert X Lao, Tuhin Maity, Monica Z Wu, Katherine McJunkin, Quaid D Morris, Timothy R Hughes, Jacqueline A Wilce, Julie M Claycomb, Zhiping Weng, Peter R Boag
Publikováno v:
eLife, Vol 7 (2018)
Proper regulation of germline gene expression is essential for fertility and maintaining species integrity. In the C. elegans germline, a diverse repertoire of regulatory pathways promote the expression of endogenous germline genes and limit the expr
Externí odkaz:
https://doaj.org/article/02c779641e7847d38284aedcaf454370
Publikováno v:
Frontiers in Molecular Biosciences, Vol 4 (2017)
Growth factor receptor bound protein 7 (Grb7) is an adaptor protein with established roles in the progression of both breast and pancreatic cancers. Through its C-terminal SH2 domain, Grb7 binds to phosphorylated tyrosine kinases to promote prolifera
Externí odkaz:
https://doaj.org/article/482bae1ab93e491496655d5cce312e3b
Autor:
Ram Prasad Bhusal, Pramod Aryal, Shankar Raj Devkota, Rina Pokhrel, Menachem J. Gunzburg, Simon R. Foster, Herman D. Lim, Richard J. Payne, Matthew C. J. Wilce, Martin J. Stone
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(9)
As natural chemokine inhibitors, evasin proteins produced in tick saliva are potential therapeutic agents for numerous inflammatory diseases. Engineering evasins to block the desired chemokines and avoid off-target side effects requires structural un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2454c667f2d1c3b56383b01c9509197a
https://pubmed.ncbi.nlm.nih.gov/35217625
https://pubmed.ncbi.nlm.nih.gov/35217625
Autor:
Matthew C.J. Wilce, Danella L West, Simon Crawford, Fionna E. Loughlin, Jacqueline A. Wilce, Saboora Waris, Menachem J. Gunzburg
Publikováno v:
Nucleic Acids Research
TIA-1 is an RNA-binding protein that sequesters target RNA into stress granules under conditions of cellular stress. Promotion of stress granule formation by TIA-1 depends upon self-association of its prion-like domain that facilitates liquid-liquid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7061d1296c88f4f685619c109afaa3ad
https://pubmed.ncbi.nlm.nih.gov/33621982
https://pubmed.ncbi.nlm.nih.gov/33621982
Autor:
Martin J. Scanlon, Ben Capuano, Lorna Wilkinson-White, Bradley C. Doak, Stephen J. Headey, Menachem J. Gunzburg, Joel P. Mackay, Luke A. Adams
The development of low-affinity fragment hits into higher affinity leads is a major hurdle in fragment-based drug design. Here we demonstrate an approach for the Rapid Elaboration of Fragments into Leads (REFiL) applying an integrated workflow that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea2d21a7e1661748dc4e9d99108608f
https://doi.org/10.26434/chemrxiv.12026952.v1
https://doi.org/10.26434/chemrxiv.12026952.v1
Autor:
Jacqueline A. Wilce, Matthew C.J. Wilce, Patrick Perlmutter, Gabrielle M. Watson, Jianrong Sang, Menachem J. Gunzburg, Xiuquan Ma, Ketav Kulkarni
Publikováno v:
Journal of Medicinal Chemistry. 60:9349-9359
Grb7 is a signaling protein with critical roles in tumor cell proliferation and migration and an established cancer therapeutic target. Here we explore chemical space to develop a new bicyclic peptide inhibitor, incorporating thioether and lactam lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c8deed38a2a193aa0bc4b3f9338740
https://doi.org/10.1021/acs.jmedchem.7b01320
https://doi.org/10.1021/acs.jmedchem.7b01320
Autor:
Joshua Wt Anderson, Menachem J. Gunzburg, Timothy P. Hughes, Debashish Ray, Gregory M. Davis, Uri Seroussi, Sean P Shrubsole, Monica Z. Wu, Julie M. Claycomb, Peter R. Boag, Quaid Morris, Zhiping Weng, Jacqueline A. Wilce, Julia A. Sobotka, Shikui Tu, Rhys N Colson, Tuhin S. Maity, Robert X Lao, Katherine McJunkin, Michelle A Francisco
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Proper regulation of germline gene expression is essential for fertility and maintaining species integrity. In the C. elegans germline, a diverse repertoire of regulatory pathways promote the expression of endogenous germline genes and limit the expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73fed43f02878d9aef31fe2720ab94b7
http://europepmc.org/articles/PMC6351104
http://europepmc.org/articles/PMC6351104