Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mena Cimino"'
Autor:
Maxime Mistretta, Mena Cimino, Pascal Campagne, Stevenn Volant, Etienne Kornobis, Olivier Hebert, Christophe Rochais, Patrick Dallemagne, Cédric Lecoutey, Camille Tisnerat, Alban Lepailleur, Yann Ayotte, Steven R. LaPlante, Nicolas Gangneux, Monika Záhorszká, Jana Korduláková, Sophie Vichier-Guerre, Frédéric Bonhomme, Laura Pokorny, Marvin Albert, Jean-Yves Tinevez, Giulia Manina
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Drug-recalcitrant infections are a leading global-health concern. Bacterial cells benefit from phenotypic variation, which can suggest effective antimicrobial strategies. However, probing phenotypic variation entails spatiotemporal analysis
Externí odkaz:
https://doaj.org/article/fa9c75f3b4af4a52a3bae94cff9e5192
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-9 (2017)
Abstract Background Tuberculosis (TB) is caused by Mycobacterium tuberculosis and represents one of the major challenges facing drug discovery initiatives worldwide. The considerable rise in bacterial drug resistance in recent years has led to the ne
Externí odkaz:
https://doaj.org/article/9d539ce22669430e9264ba01e6742a5a
Autor:
Olga Mestre, Raquel Hurtado-Ortiz, Tiago Dos Vultos, Amine Namouchi, Mena Cimino, Madalena Pimentel, Olivier Neyrolles, Brigitte Gicquel
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53486 (2013)
Mycobacterium tuberculosis has the remarkable capacity to survive within the hostile environment of the macrophage, and to resist potent antibacterial molecules such as reactive oxygen species (ROS). Thus, understanding mycobacterial resistance mecha
Externí odkaz:
https://doaj.org/article/81f705ad3b37454c986a168e7f3abf31
Autor:
Mena Cimino, Christophe Thomas, Amine Namouchi, Sarah Dubrac, Brigitte Gicquel, Deshmukh N Gopaul
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42876 (2012)
BACKGROUND: The Mycobacterium tuberculosis PhoP/PhoR two-component signal transduction system controls the expression of about 2% of the genome and plays a major role in pathogenicity. However, its regulon has not been well characterized. METHODOLOGY
Externí odkaz:
https://doaj.org/article/ee6047195d9a44e28905324457ed7d39
Autor:
Maxime Mistretta, Mena Cimino, Pascal Campagne, Stevenn Volant, Etienne Kornobis, Olivier Hebert, Christophe Rochais, Patrick Dallemagne, Cédric Lecoutey, Camille Tisnerat, Alban Lepailleur, Yann Ayotte, Steven R. LaPlante, Nicolas Gangneux, Monika Záhorszká, Jana Korduláková, Sophie Vichier-Guerre, Frédéric Bonhomme, Laura Pokorny, Marvin Albert, Jean-Yves Tinevez, Giulia Manina
Drug-recalcitrant infections are a leading global-health concern. Bacterial cells benefit from phenotypic variation, which can suggest effective anti-microbial strategies. However, probing phenotypic variation entails spatiotemporal analysis of indiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::341d224a1ebe6ec3997b591329728341
https://doi.org/10.1101/2023.03.31.535085
https://doi.org/10.1101/2023.03.31.535085
Autor:
Laura Cioetto-Mazzabò, Francesca Boldrin, Claire Beauvineau, Martin Speth, Alberto Marina, Amine Namouchi, Greta Segafreddo, Mena Cimino, Sandrine Favre-Rochex, Seetha Balasingham, Beatriz Trastoy, Hélène Munier-Lehmann, Gareth Griffiths, Brigitte Gicquel, Marcelo E Guerin, Riccardo Manganelli, Noelia Alonso-Rodríguez
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2023, 51 (1), pp.144-165. ⟨10.1093/nar/gkac1173⟩
Nucleic Acids Research, 2023, 51 (1), pp.144-165. ⟨10.1093/nar/gkac1173⟩
The emergence of drug-resistant Mycobacterium tuberculosis strains highlights the need to discover anti-tuberculosis drugs with novel mechanisms of action. Here we discovered a mycobactericidal strategy based on the prodrug activation of selected che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94091fc5c666832d004bd83e00b3c133
https://hal.science/hal-04117778
https://hal.science/hal-04117778
Autor:
Paul Ogadinma, Yann Ayotte, Laurent Chatel-Chaix, François Bilodeau, Marthe Lebughe, Mena Cimino, Giulia Manina, Aïssatou Aïcha Sow, Frédéric J. Veyrier, Albert Descoteaux, Eve Bernet, Dominic Gagnon, Sarah-Lisa Ouali, Maxime Mistretta, Dave Richard, Steven R. LaPlante
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, 2021, 16 (11), pp.2158-2163. ⟨10.1021/acschembio.1c00657⟩
ACS Chemical Biology, 2021, 16 (11), pp.2158-2163. ⟨10.1021/acschembio.1c00657⟩
International audience; Fragment-based lead discovery has emerged over the last decades as one of the most powerful techniques for identifying starting chemical matter to target specific proteins or nucleic acids in vitro. However, the use of such lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520f95ea52cd1b9e6547f5e3c06e7b81
https://pubmed.ncbi.nlm.nih.gov/34699722
https://pubmed.ncbi.nlm.nih.gov/34699722
Autor:
Rita, Székely, Monica, Rengifo-Gonzalez, Vinayak, Singh, Olga, Riabova, Andrej, Benjak, Jérémie, Piton, Mena, Cimino, Etienne, Kornobis, Valerie, Mizrahi, Kai, Johnsson, Giulia, Manina, Vadim, Makarov, Stewart T, Cole
Publikováno v:
ACS infectious diseases. 6(11)
Screening of a diversity-oriented compound library led to the identification of two 6,11-dioxobenzo[
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::20bc613cb3ee5e2ecd48ca769261dc30
https://pubmed.ncbi.nlm.nih.gov/32930569
https://pubmed.ncbi.nlm.nih.gov/32930569
Autor:
Patrick Dallemagne, Mahama Ouattara, Cédric Lecoutey, Songuigama Coulibaly, Julien Briffotaux, Maria Virginia Buchieri, Christophe Rochais, Noelia Alonso-Rodriguez, Mena Cimino, Brigitte Gicquel, Damien Mornico
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2020, 207, pp.112821. ⟨10.1016/j.ejmech.2020.112821⟩
European Journal of Medicinal Chemistry, 2020, 207, pp.112821. ⟨10.1016/j.ejmech.2020.112821⟩
European Journal of Medicinal Chemistry, Elsevier, 2020, 207, pp.112821. ⟨10.1016/j.ejmech.2020.112821⟩
European Journal of Medicinal Chemistry, 2020, 207, pp.112821. ⟨10.1016/j.ejmech.2020.112821⟩
International audience; Several phenanthrolinic analogs of quinolones have been synthesized and their antibacterial activity tested against Mycobacterium tuberculosis, other mycobacterial species and bacteria from other genera. Some of them show high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264c1673e515d98e3659bafffbd189cb
https://hal-pasteur.archives-ouvertes.fr/pasteur-03261309
https://hal-pasteur.archives-ouvertes.fr/pasteur-03261309
Autor:
Gerald Larrouy-Maumus, Sandrine Favre-Rochex, Alessandro Cascioferro, Hélène Munier-Lehmann, Sonia Rebollo-Ramirez, Claire Beauvineau, Delphine Naud-Martin, Mena Cimino, Brigitte Gicquel, Maria Virginia Buchieri, Olivier Helynck
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (17), pp.7425-7433. ⟨10.1021/acs.jmedchem.7b00726⟩
Journal of Medicinal Chemistry, 2017, 60 (17), pp.7425-7433. ⟨10.1021/acs.jmedchem.7b00726⟩
Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (17), pp.7425-7433. ⟨10.1021/acs.jmedchem.7b00726⟩
Journal of Medicinal Chemistry, 2017, 60 (17), pp.7425-7433. ⟨10.1021/acs.jmedchem.7b00726⟩
International audience; In this study, we aimed to decipher the natural resistance mechanisms of mycobacteria against novel compounds isolated by whole-cell-based high-throughput screening (HTS). We identified active compounds using Mycobacterium aur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc121eccd96b56ad0e81344220e3315b
https://doi.org/10.1021/acs.jmedchem.7b00726
https://doi.org/10.1021/acs.jmedchem.7b00726