Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Men Thi Hoai Duong"'
1
Akademický článek
C-Jun N-terminal kinase inhibitors: Structural insight into kinase-inhibitor complexes
Autor: Men Thi Hoai Duong, Joon-Hwa Lee, Hee-Chul Ahn
Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1440-1457 (2020)
The activation of c-Jun N-terminal kinases (JNKs) plays an important role in physiological processes including neuronal function, immune activity, and development, and thus, JNKs have been a therapeutic target for various diseases such as neurodegene
Externí odkaz: https://doaj.org/article/43e7cb1b698640da9d3a4027d3c6fbfa
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2
Akademický článek
Fragment-Based and Structural Investigation for Discovery of JNK3 Inhibitors
Autor: Men Thi Hoai Duong, Hee-Chul Ahn
Publikováno v: Pharmaceutics, Vol 14, Iss 9, p 1900 (2022)
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are related to cell proliferation, gene expression, and cell death. JNK isoform 3 (JNK3) is an important therapeutic target in varieties of path
Externí odkaz: https://doaj.org/article/1910567bcefd4ec58c74645a482252f4
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3
Akademický článek
Structural Comparison of hMDH2 Complexed with Natural Substrates and Cofactors: The Importance of Phosphate Binding for Active Conformation and Catalysis
Autor: Yumi Eo, Men Thi Hoai Duong, Hee-Chul Ahn
Publikováno v: Biomolecules, Vol 12, Iss 9, p 1175 (2022)
Malate dehydrogenase (MDH), which catalyzes a reversible conversion of L-malate to oxaloacetate, plays essential roles in common metabolic processes, such as the tricarboxylic acid cycle, the oxaloacetate–malate shuttle, and the glyoxylate cycle. M
Externí odkaz: https://doaj.org/article/8e39df3009fd4d299cce8670b42d4063
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4
Akademický článek
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5
Akademický článek
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6
Sonidegib Suppresses Production of Inflammatory Mediators and Cell Migration in BV2 Microglial Cells and Mice Treated with Lipopolysaccharide via JNK and NF-κB Inhibition
Autor: Ngoc Minh Nguyen, Men Thi Hoai Duong, Bich Phuong Bui, Phuong Linh Nguyen, Xiaozhen Chen, Jungsook Cho, Hee-Chul Ahn
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10590
Our structure-based virtual screening of the FDA-approved drug library has revealed that sonidegib, a smoothened antagonist clinically used to treat basal cell carcinoma, is a potential c-Jun N-terminal kinase 3 (JNK3) inhibitor. This study investiga
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a38f7dc826c409783e0f547795db330
https://pubmed.ncbi.nlm.nih.gov/36142500
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7
Efonidipine Inhibits JNK and NF-κB Pathway to Attenuate Inflammation and Cell Migration Induced by Lipopolysaccharide in Microglial Cells
Autor: Ngoc Minh Nguyen, Men Thi Hoai Duong, Phuong Linh Nguyen, Bich Phuong Bui, Hee-Chul Ahn, Jungsook Cho
Publikováno v: Biomoleculestherapeutics. 30(5)
Efonidipine, a calcium channel blocker, is widely used for the treatment of hypertension and cardiovascular diseases. In our preliminary study using structure-based virtual screening, efonidipine was identified as a potential inhibitor of c-Jun N-ter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49027464de28d52385fe6cbc9c358f43
https://pubmed.ncbi.nlm.nih.gov/35993250
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8
A mixture of chloromethylisothiazolinone and methylisothiazolinone impairs rat vascular smooth muscle by depleting thiols and thereby elevating cytosolic Zn2+ and generating reactive oxygen species
Autor: Yoon Seok Seo, Sang Kyum Kim, Jung-Min Park, Van Quan Do, Moo Yeol Lee, Men Thi Hoai Duong, Hee Chul Ahn, Jieun Yu, Junichi Nakai
Publikováno v: Archives of Toxicology. 95:541-556
Chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) are biocidal preservatives and the active ingredients in Kathon CG, which contains ca. 1.5% mixture of CMIT and MIT at a ratio of 3:1 (CMIT/MIT). CMIT/MIT was misused as humidifier di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb4171b9ea10842ae37e32c8f8335a36
https://doi.org/10.1007/s00204-020-02930-z
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10
Suppression of LPS-Induced Inflammation and Cell Migration by Azelastine through Inhibition of JNK/NF-κB Pathway in BV2 Microglial Cells
Autor: Bich Phuong Bui, Men Thi Hoai Duong, Kyeong Lee, Hee-Chul Ahn, Jungsook Cho, Phuong Linh Nguyen
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9061, p 9061 (2021)
Volume 22
Issue 16
The c-Jun N-terminal kinases (JNKs) are implicated in many neuropathological conditions, including neurodegenerative diseases. To explore potential JNK3 inhibitors from the U.S. Food and Drug Administration-approved drug library, we performed structu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e35bba35982253f63168406206efc8
https://pubmed.ncbi.nlm.nih.gov/34445767
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