Výsledky vyhledávání - "Memory B Cells/immunology"

Secretory IgA and T cells targeting SARS-CoV-2 spike protein are transferred to the breastmilk upon mRNA vaccination

Autor: Filipe Ferreira, Margarida Archer, Maria João Amorim, Diogo Athayde, Fátima Serrano, Helena Soares, A. Margarida Juliano, Nádia Charepe, Marta Alenquer, Juliana Gonçalves

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cell Reports Medicine

In view of the scarcity of data to guide decision making, we evaluated how BNT162b2 and mRNA-1273 vaccines affect the immune response in lactating women and the protective profile of breastmilk. Compared with controls, lactating women had a higher fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0697d0233892737494159ff341ef8be

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BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors

Autor: Eirini Sevdali, Violeta Block, Marie Lataretu, Huiying Li, Cristian R. Smulski, Jana-Susann Briem, Yannic Heitz, Beate Fischer, Neftali-Jose Ramirez, Bodo Grimbacher, Hans-Martin Jäck, Reinhard E. Voll, Martin Hölzer, Pascal Schneider, Hermann Eibel

Publikováno v: Cell reports, vol. 39, no. 13, pp. 111019

Binding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the same levels of BAFFR, but only memory B cells seem to survive witho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89a50854c4165b9b92eb2c12a699f6d
https://doi.org/10.1016/j.celrep.2022.111019

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Single-cell transcriptome profiling and the use of AID deficient mice reveal that B cell activation combined with antibody class switch recombination and somatic hypermutation do not benefit the control of experimental trypanosomosis

Autor: Magdalena Radwanska, Stefan Magez, Hang Thi Thu Nguyen, Robin B. Guevarra

Publikováno v: PLoS Pathogens
PLOS PATHOGENS
PLoS Pathogens, Vol 17, Iss 11, p e1010026 (2021)

Salivarian trypanosomes are extracellular protozoan parasites causing infections in a wide range of mammalian hosts, with Trypanosoma evansi having the widest geographic distribution, reaching territories far outside Africa and occasionally even Euro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47e3f7f7cb5d23162e5d5c18750af98
https://pubmed.ncbi.nlm.nih.gov/34762705

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