Výsledky vyhledávání - "Membrane transport and intracellular motility Translational research [NCMLS 5]"

Autor: Kenneth M. Yamada, Peter Friedl, Erik Sahai, Stephen J. Weiss

Publikováno v: Nature Reviews. Molecular Cell Biology, 13, 743-7
Nature Reviews. Molecular Cell Biology, 13, 11, pp. 743-7

Item does not contain fulltext Studies of cell migration in three-dimensional (3D) cell culture systems and in vivo have revealed several differences when compared with cell migration in two dimensions, including their morphology and mechanical and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df44fea257f8be8367485ec4975cc76
https://doi.org/10.1038/nrm3459

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PED/PEA‐15 controls fibroblast motility and wound closure by ERK1/2‐dependent mechanisms

Autor: Ferdinando Giacco, Claudia Miele, Sergio Caserta, Angela Cassese, Francesco Beguinot, Pietro Formisano, Francesco Oriente, Corrado Garbi, Stefano Guido, Valentina Pagliara, Roberta Buonomo, Angela Vasaturo, Giuseppe Perruolo, Gelsomina Mansueto

Publikováno v: Journal of Cellular Physiology
Journal of Cellular Physiology; Vol 227
Journal of Cellular Physiology, 227, 5, pp. 2106-16
Journal of Cellular Physiology, 227, 2106-16
Journal of cellular physiology
(2012).
info:cnr-pdr/source/autori:Buonomo R, Giacco F, Vasaturo A, Caserta S, Guido S, Pagliara V, Garbi C, Mansueto G, Cassese A, Perruolo G, Oriente F, Miele C, Beguinot F, Formisano P./titolo:PED%2FPEA-15 controls fibroblast motility and wound closure by ERK1%2F2-dependent mechanisms./doi:/rivista:Journal of cellular physiology (Print)/anno:2012/pagina_da:/pagina_a:/intervallo_pagine:/volume

Cell migration is dependent on the control of signaling events that play significant roles in creating contractile force and in contributing to wound closure. We evaluated wound closure in fibroblasts from mice overexpressing (TgPED) or lacking ped/p

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https://doi.org/10.1002/jcp.22944

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Recording Intracellular Molecular Events from the Outside: Glycosylphosphatidylinositol-Anchored Avidin as a Reporter Protein for In Vivo Imaging

Autor: Steffi Lehmann, Alain Blanc, Markus Rudin, Ruth Keist, Roger Schibli, Elisa García Garayoa

Publikováno v: The Journal of Nuclear Medicine (1978), 52, 445-52
The Journal of Nuclear Medicine (1978), 52, 3, pp. 445-52

Item does not contain fulltext With the emergence of multimodal imaging strategies, genetically encoded reporters that can be flexibly combined with any imaging modality become highly attractive. Here we describe the use of glycosylphosphatidylinosit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cccd6cdb60c85ca3ed4206bc44b8c492
https://doi.org/10.2967/jnumed.110.082412

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Cytotoxic T lymphocyte migration and effector function in the tumor microenvironment

Autor: Peter Friedl, Marina Krause, Bettina Weigelin

Publikováno v: Immunology Letters, 138, 19-21
Immunology Letters, 138, 1, pp. 19-21

Item does not contain fulltext Immunological control of cancer lesions requires local uptake of tumor-specific antigen followed by the activation and expansion of tumor specific cytotoxic T-lymphocytes (CTL). An efficient effector phase further depen

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https://doi.org/10.1016/j.imlet.2011.02.016

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Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response

Autor: Bettina Weigelin, Peter Friedl, Stephanie Alexander, Frank Winkler

Publikováno v: Current Opinion in Cell Biology, 25, 5, pp. 659-71
Current Opinion in Cell Biology, 25, 659-71

Item does not contain fulltext Key steps of cancer progression and therapy response depend upon interactions between cancer cells with the reactive tumour microenvironment. Intravital microscopy enables multi-modal and multi-scale monitoring of cance

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https://pubmed.ncbi.nlm.nih.gov/23896198

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A Cellular Potts Model simulating cell migration on and in matrix environments

Autor: Katarina Wolf, Luigi Preziosi, Marco Scianna

Publikováno v: Mathematical Biosciences and Engineering, 10, 235-61
Mathematical Biosciences and Engineering, 10, 1, pp. 235-61

Item does not contain fulltext Cell migration on and through extracellular matrix is fundamental in a wide variety of physiological and pathological phenomena, and is exploited in scaffold-based tissue engineering. Migration is regulated by a number

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99c39ed32dbfa31920e609831064628
https://doi.org/10.3934/mbe.2013.10.235

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A new, straightforward ex vivo organoid bladder mucosal model for preclinical research

Autor: Dick A W Janssen, Julia Odenthal, Wout Feitz, Jack A. Schalken, John Heesakkers, Paul J. Geutjes, Toin H. van Kuppevelt

Publikováno v: Journal of Urology, 190, 341-9
Journal of Urology, 190, 1, pp. 341-9

Item does not contain fulltext PURPOSE: We developed an experimental ex vivo organoid bladder mucosal model that can be used for experimental research purposes to create alternatives to current animal models. MATERIALS AND METHODS: We developed an ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3531065eddcdf75eaf35fef5390cef8
https://doi.org/10.1016/j.juro.2012.12.103

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Mechanotransduction of mesenchymal melanoma cell invasion into 3D collagen lattices: Filopod-mediated extension-relaxation cycles and force anisotropy

Autor: Peter Friedl, Kerstin Maaser, Bernhard Wehrle-Haller, Josefine Starke

Publikováno v: Experimental Cell Research, 319, 2424-33
Experimental Cell Research, 319, 16, pp. 2424-33
Experimental Cell Research, Vol. 319, No 16 (2013) pp. 2424-2433

Item does not contain fulltext Mesenchymal cell migration in interstitial tissue is a cyclic process of coordinated leading edge protrusion, adhesive interaction with extracellular matrix (ECM) ligands, cell contraction followed by retraction and mov

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https://doi.org/10.1016/j.yexcr.2013.04.003

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Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

Autor: Amanda L. Willis, Katarina Wolf, Mariska te Lindert, Stephen J. Weiss, Robert M. Hoffman, Carl G. Figdor, Peter Friedl, Marina Krause, Joost te Riet, Stephanie Alexander

Publikováno v: Journal of Cell Biology, 201, 7, pp. 1069-84
Journal of Cell Biology, 201, 1069-84

Item does not contain fulltext Cell migration through 3D tissue depends on a physicochemical balance between cell deformability and physical tissue constraints. Migration rates are further governed by the capacity to degrade ECM by proteolytic enzyme

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https://doi.org/10.1083/jcb.201210152

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Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1-HSP90

Autor: Dennis J. Eastburn, Mirjam M. P. Zegers, Keith E. Mostov

Publikováno v: Development (Cambridge), vol 139, iss 18
Eastburn, DJ; Zegers, MM; & Mostov, KE. (2012). Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1-HSP90. Journal of Cell Science, 125(17), 4147-4157. doi: 10.1242/jcs.108670. UCSF: Retrieved from: http://www.escholarship.org/uc/item/73x4g7s5
Journal of Cell Science, 125, Pt 17, pp. 4147-57
Journal of cell science, vol 125, iss Pt 17
Journal of Cell Science, 125, 4147-57
Eastburn, DJ; Zegers, MM; & Mostov, KE. (2012). Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1-HSP90. Development (Cambridge), 139(18), 1-30. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1r42k1v0

Item does not contain fulltext Scribble was originally identified as a Drosophila protein that regulates epithelial polarity and formation of the basolateral surface. The mammalian orthologue, Scrib, is evolutionarily conserved, but does not appear t

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https://escholarship.org/uc/item/1r42k1v0

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