Zobrazeno 1 - 10
of 2 661
pro vyhledávání: '"Membrane interaction"'
Autor:
Maki Mizogami, Hironori Tsuchiya
Publikováno v:
Future Pharmacology, Vol 4, Iss 2, Pp 437-448 (2024)
Among nonsteroidal anti-inflammatory drugs, ibuprofen, diclofenac, and celecoxib have been frequently used in multimodal analgesia. Recent studies challenge the conventional theory that they exhibit activity and toxicity by acting on cyclooxygenase s
Externí odkaz:
https://doaj.org/article/971a907586ed47bd9e9b1fb722236cd0
Publikováno v:
Biophysica, Vol 4, Iss 2, Pp 207-226 (2024)
Drug delivery systems play a pivotal role in targeted pharmaceutical transport and controlled release at specific sites. Liposomes, commonly used as drug carriers, constitute a fundamental part of these systems. Moreover, the drug–liposome model se
Externí odkaz:
https://doaj.org/article/7ac1039f615b49658f84df96c05654a7
Autor:
Chae Eun Lee, Sungjun Kim, Hee Won Park, Wonjeong Lee, Ashok Kumar Jangid, Yonghyun Choi, Woo-Jin Jeong, Kyobum Kim
Publikováno v:
Nano Convergence, Vol 10, Iss 1, Pp 1-13 (2023)
Abstract Natural killer (NK) cells have clinical advantages in adoptive cell therapy owing to their inherent anticancer efficacy and their ability to identify and eliminate malignant tumors. However, insufficient cancer-targeting ligands on NK cell s
Externí odkaz:
https://doaj.org/article/272cce9355d344deaf7274c6b8423662
Autor:
Rosa Bellavita, Annarita Falanga, Francesco Merlino, Gabriella D’Auria, Nicola Molfetta, Anella Saviano, Francesco Maione, Umberto Galdiero, Maria Rosaria Catania, Stefania Galdiero, Paolo Grieco, Emanuela Roscetto, Lucia Falcigno, Elisabetta Buommino
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 36-50 (2023)
The increasing resistance of fungi to conventional antifungal drugs has prompted worldwide the search for new compounds. In this work, we investigated the antifungal properties of acylated Temporin L derivatives, Pent-1B and Dec-1B, against Candida a
Externí odkaz:
https://doaj.org/article/39c43ad04aa145468deb70d283b01f6c
Publikováno v:
Biophysica, Vol 3, Iss 4, Pp 620-635 (2023)
The cell-penetrating peptide (CPP) penetratin (PEN) has garnered attention for its potential to enter tumor cells. However, its translocation mechanism and lack of selectivity remain debated. This study investigated PEN’s insertion into healthy cel
Externí odkaz:
https://doaj.org/article/8656dea1316e44c68fa6e24ce78e6dc1
Autor:
Weining Yin, Junting Yao, Xuwei Leng, Chengbang Ma, Xiaoling Chen, Yangyang Jiang, Tao Wang, Tianbao Chen, Chris Shaw, Mei Zhou, Lei Wang
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 1098 (2024)
Antibiotic resistance poses a serious threat to public health globally, reducing the effectiveness of conventional antibiotics in treating bacterial infections. ESKAPE pathogens are a group of highly transmissible bacteria that mainly contribute to t
Externí odkaz:
https://doaj.org/article/ba36cd16f7284bf3869172d63390aded
Publikováno v:
Journal of Analytical Science and Technology, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Amphipathic α-helical peptides (AHPs) have shown potential as a therapeutic approach against multi-drug-resistant bacterial infections due to their broad-spectrum antimicrobial activity by disrupting bacterial membranes. However, their nons
Externí odkaz:
https://doaj.org/article/7a95bdaacf514c43b83343fc1a1ac265
Autor:
Liana Costa Pereira Vilas Boas, Danieli Fernanda Buccini, Rhayfa Lorrayne Araújo Berlanda, Bruno de Paula Oliveira Santos, Mariana Rocha Maximiano, Luciano Morais Lião, Sónia Gonçalves, Nuno C. Santos, Octávio Luiz Franco
Publikováno v:
Viruses, Vol 16, Iss 6, p 948 (2024)
Human alphaherpesvirus 1 (HSV-1) is a significantly widespread viral pathogen causing recurrent infections that are currently incurable despite available treatment protocols. Studies have highlighted the potential of antimicrobial peptides sourced fr
Externí odkaz:
https://doaj.org/article/948ac4f3521049b6aacf91238513b194
Autor:
Sushanth Gudlur, Filipe Viana Ferreira, Javier Shu Ming Ting, Carmen Domene, Syed Maricar, Anton P. Le Brun, Nageshwar Yepuri, Michael Moir, Robert Russell, Tamim Darwish, Ali Miserez, Marité Cárdenas
Publikováno v:
Frontiers in Soft Matter, Vol 3 (2024)
Peptide-based liquid droplets (coacervates) produced by spontaneous liquid-liquid phase separation (LLPS), have emerged as a promising class of drug delivery systems due to their high entrapping efficiency and the simplicity of their formulation. How
Externí odkaz:
https://doaj.org/article/e7f747c19c1e4446a35d005be56c212d
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3456 (2024)
The linear undecapeptide KKLFKKILKYL-NH2 (BP100) highlights for its antibacterial activity against Gram-negative bacteria and its low toxicity. These excellent biological properties prompted the investigation of its mechanism of action, which were un
Externí odkaz:
https://doaj.org/article/8fc13b94245245799ac764a953475070