Editorial: Perforins and Cholesterol-Dependent Cytolysins in Immunity and Pathogenesis

Autor: George P. Munson, Robert J. C. Gilbert, Gabriele Pradel

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Externí odkaz: https://doaj.org/article/98dbd3af90104f8787cd8bc906f36b19

Serum Complement Activation by C4BP-IgM Fusion Protein Can Restore Susceptibility to Antibiotics in Neisseria gonorrhoeae

Autor: Serena Bettoni, Karolina Maziarz, M Rhia L Stone, Mark A T Blaskovich, Jan Potempa, Maria Luiza Bazzo, Magnus Unemo, Sanjay Ram, Anna M. Blom

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Neisseria gonorrhoeae is the etiological agent of gonorrhea, the second most common bacterial sexually transmitted infection worldwide. Reproductive sequelae of gonorrhea include infertility, ectopic pregnancy and chronic pelvic pain. Most antibiotic

Externí odkaz: https://doaj.org/article/03c7d679788e4513a54e468ecd9f8a56

Deposition of the Membrane Attack Complex in Healthy and Diseased Human Kidneys

Autor: Jacob J. E. Koopman, Mieke F. van Essen, Helmut G. Rennke, Aiko P. J. de Vries, Cees van Kooten

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

The membrane attack complex—also known as C5b-9—is the end-product of the classical, lectin, and alternative complement pathways. It is thought to play an important role in the pathogenesis of various kidney diseases by causing cellular injury an

Externí odkaz: https://doaj.org/article/5ed534407d7945cb90453cf0eea900ce

Molecular Mechanisms Involved in Pseudomonas aeruginosa Bacteremia

Autor: Stéphane Pont, Manon Janet-Maitre, Eric Faudry, François Cretin, Ina Attrée

Publikováno v: Pseudomonas aeruginosa
Pseudomonas aeruginosa, 1386, Springer International Publishing, pp.325-345, 2022, Advances in Experimental Medicine and Biology, ⟨10.1007/978-3-031-08491-1_12⟩
Advances in Experimental Medicine and Biology ISBN: 9783031084904

International audience; Bloodstream infections (BSI) with Pseudomonas aeruginosa account for 8.5% of all BSIs, their mortality rate, at about 40%, is the highest among causative agents. For this reason and due to its intrinsic and acquired resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b6583a981fbbc0175d09718b8bd347
https://hal.science/hal-03917582

Complement-5 Inhibition Deters Progression of Fulminant Hepatitis to Acute Liver Failure in Murine ModelsSummary

Autor: Junya Kawasoe, Yusuke Okamura, Tatsuaki Tsuruyama, Tetsuya Tajima, Shinji Uemoto, Ichiro Tamaki, Jiro Kusakabe, Hidetaka Miyauchi, Tatsuya Okamoto, Yi Wang, Xiangdong Zhao, Koichiro Hata

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1351-1367 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Acute liver failure (ALF) is a life-threatening condition with limited treatment alternatives. ALF pathogenesis seemingly involves the complement system. However, no complement-targeted intervention has been clinically applied. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6669f967241dbe7c95b87171c6e3a302
http://www.sciencedirect.com/science/article/pii/S2352345X21000011