Multilayered Computational Framework for Designing Peptide Inhibitors of HVEM-LIGHT Interaction.

Autor: Ciura P; Faculty of Chemistry, Fahrenheit Union of Universities in Gdańsk, University of Gdańsk, Baż̇yńskiego 8, 80-309 Gdansḱ, Poland., Smardz P; Institute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, 02-668 Warsaw, Poland., Spodzieja M; Faculty of Chemistry, Fahrenheit Union of Universities in Gdańsk, University of Gdańsk, Baż̇yńskiego 8, 80-309 Gdansḱ, Poland., Sieradzan AK; Faculty of Chemistry, Fahrenheit Union of Universities in Gdańsk, University of Gdańsk, Baż̇yńskiego 8, 80-309 Gdansḱ, Poland., Krupa P; Institute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, 02-668 Warsaw, Poland.

Publikováno v: The journal of physical chemistry. B [J Phys Chem B] 2024 Jul 18; Vol. 128 (28), pp. 6770-6785. Date of Electronic Publication: 2024 Jul 03.

HVEM in acute lymphocytic leukemia facilitates tumour immune escape by inhibiting CD8 ⁺ T cell function.

Autor: Liu Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Wang L; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China. wanglx37@mail2.sysu.edu.cn.; Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. wanglx37@mail2.sysu.edu.cn., Li Y; Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Zhong C; Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Wang X; Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Wang X; Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Xia Z; Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Liao J; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, China., Huang C; Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China., Mao C; Department of Anatomy and Histology, Shenzhen University Medical School, Shenzhen, China., Feng Y; Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Luo C; Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Mai W; Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Song H; Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Li H; Guangdong Engineering and Technology Research Center for Disease-Model Animals, Laboratory Animal Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Bao L; Yichun Central Blood Station, Yichun, China., Chen D; Department of Pediatrics, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China., Sheng Y; Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, China., Zhang H; Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Wei X; Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China., Chen J; Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. chenjun23@mail.sysu.edu.cn.; Guangdong Engineering and Technology Research Center for Disease-Model Animals, Laboratory Animal Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. chenjun23@mail.sysu.edu.cn.; Key Laboratory of Tropical Disease Control of the Ministry of Education, Sun Yat-sen University, Guangzhou, China. chenjun23@mail.sysu.edu.cn.; Jinfeng Laboratory, Chongqing, China. chenjun23@mail.sysu.edu.cn., Yi W; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China. yiwei@gzzoc.com.

Publikováno v: Cellular oncology (Dordrecht, Netherlands) [Cell Oncol (Dordr)] 2024 Oct; Vol. 47 (5), pp. 1779-1796. Date of Electronic Publication: 2024 May 29.

Distinct characteristics of BTLA/HVEM axis expression on Tregs and its impact on the expansion and attributes of Tregs in patients with active pulmonary tuberculosis.

Autor: Tang P; Department of Biochemistry and Molecular Biology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.; Department of Tuberculosis, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital of Soochow University, Suzhou, China., Shen X; Department of Critical Care Medicine, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital of Soochow University, Suzhou, China., Gao J; Department of Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou, China., Zhang J; Department of Tuberculosis, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital of Soochow University, Suzhou, China., Feng Y; Department of Tuberculosis, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Disease Hospital of Soochow University, Suzhou, China., Zhang J; Department of Ophthalmology, The Second Affiliated Hospital of Suzhou University, Suzhou, China., Huang Z; Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Gastrointestinal Tumor Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China., Wang X; Department of Biochemistry and Molecular Biology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.

Publikováno v: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2024 Sep 25; Vol. 14, pp. 1437207. Date of Electronic Publication: 2024 Sep 25 (Print Publication: 2024).

Chimeric Antigen Receptor T Cell Bearing Herpes Virus Entry Mediator Co-Stimulatory Signal Domain Exhibits Exhaustion-Resistant Properties.

Autor: Nunoya JI; Department of Microbiology, Dokkyo Medical University School of Medicine, Tochigi 321-0293, Japan., Imuta N; Department of Microbiology, Dokkyo Medical University School of Medicine, Tochigi 321-0293, Japan., Masuda M; Department of Microbiology, Dokkyo Medical University School of Medicine, Tochigi 321-0293, Japan.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 08; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 08.

The BTLA-HVEM axis restricts CAR T cell efficacy in cancer.

Autor: Guruprasad P; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Carturan A; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Zhang Y; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Cho JH; Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA., Kumashie KG; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Patel RP; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Kim KH; R&D Center, AbClon Inc., Seoul, Republic of Korea., Lee JS; R&D Center, AbClon Inc., Seoul, Republic of Korea., Lee Y; R&D Center, AbClon Inc., Seoul, Republic of Korea., Kim JH; R&D Center, AbClon Inc., Seoul, Republic of Korea., Chung J; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea., Joshi A; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Cohen I; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Shestov M; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Ghilardi G; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Harris J; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Pajarillo R; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Angelos M; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Lee YG; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.; College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Republic of Korea., Liu S; Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA., Rodriguez J; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Wang M; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Ballard HJ; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Gupta A; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Ugwuanyi OH; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Hong SJA; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Bochi-Layec AC; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Sauter CT; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Chen L; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Paruzzo L; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Kammerman S; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Shestova O; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Liu D; Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA., Vella LA; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Schuster SJ; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Svoboda J; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Porazzi P; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Ruella M; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu.; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu.; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu.

Publikováno v: Nature immunology [Nat Immunol] 2024 Jun; Vol. 25 (6), pp. 1020-1032. Date of Electronic Publication: 2024 Jun 03.