Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Melvyn Baez"'
Autor:
Mark J. Benvenga, Stephen F. Chaney, Melvyn Baez, Thomas C. Britton, William J. Hornback, James A. Monn, Gerard J. Marek
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
There is substantial evidence that glutamate can modulate the effects of 5-hydroxytryptamine2A (5-HT2A) receptor activation through stimulation of metabotropic glutamate2/3 (mGlu2/3) receptors in the prefrontal cortex. Here we show that constitutive
Externí odkaz:
https://doaj.org/article/9f965940a60d4dd5ac6205b068ebae96
Autor:
Mark J, Benvenga, Stephen F, Chaney, Melvyn, Baez, Thomas C, Britton, William J, Hornback, James A, Monn, Gerard J, Marek
Publikováno v:
Frontiers in Pharmacology
There is substantial evidence that glutamate can modulate the effects of 5-hydroxytryptamine2A (5-HT2A) receptor activation through stimulation of metabotropic glutamate2/3 (mGlu2/3) receptors in the prefrontal cortex. Here we show that constitutive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c0af9b23c7f0343c501750daec48ed5
https://pubmed.ncbi.nlm.nih.gov/29599719
https://pubmed.ncbi.nlm.nih.gov/29599719
Publikováno v:
Life Sciences. 89:862-867
Aims Convergent data suggest that there is a hyperglutamatergic state that arises during relapse to drug seeking. Blockade of mGlu5 receptors provides one approach to dampening glutamate tone. However, the role of mGlu5 receptors in relapse to food s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06593b1b215b4fe3dcc4f5c451b01e35
https://doi.org/10.1016/j.lfs.2011.09.014
https://doi.org/10.1016/j.lfs.2011.09.014
Autor:
Patrick Q. Mooney, Stephanie W. Watts, Melvyn Baez, Darryle D. Schoepp, Marlene L. Cohen, Bryan G. Johnson
Publikováno v:
Journal of Neurochemistry. 62:934-943
Heterogeneity of the 5-hydroxytryptamine2 (5-HT2) receptor across species has been implicated in several pharmacological and physiological studies. Although 5-HT2 receptors in the rat have been linked to increases in phosphoinositide (PI) hydrolysis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c66a7a7a4d27ab7ff0105aa4cae3b5
https://doi.org/10.1046/j.1471-4159.1994.62030934.x
https://doi.org/10.1046/j.1471-4159.1994.62030934.x
Autor:
Christian C. Felder, Audrey B. Bergeron, David H. Randle, Hannah J. Gitschier, Melvyn Baez, Paul Goldsmith, Lisa M. Broad, Caryn E. Bacon, Douglas A. Schober, Peiyi Yang
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781493926169
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::251a65f7bdd703f8e397cbb35002bcdf
https://doi.org/10.1007/978-1-4939-2617-6_11
https://doi.org/10.1007/978-1-4939-2617-6_11
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 319:254-259
Antidepressant-like effects of metabotropic glutamate (mGlu)5 receptor antagonists have been reported previously. We now provide definitive identification of mGlu5 receptors as a target for these effects through the combined use of selective antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926d5521af2bad1ef9ff4a777a8b62a7
https://doi.org/10.1124/jpet.106.103143
https://doi.org/10.1124/jpet.106.103143
Publikováno v:
Journal of Cellular Biochemistry. 92:603-611
Neurotensin (NT) regulates a variety of biological processes primarily through interaction with neurotensin receptor-1 (NTR1), a heterotrimeric G-protein-coupled receptor (GPCR). Stimulation of NTR1 has been linked to activation of multiple signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec521c46364bea1c4a142cbf79fa1e8
https://doi.org/10.1002/jcb.20098
https://doi.org/10.1002/jcb.20098
Autor:
G. Erik Jagdmann, Joseph P. Tizzano, David O. Callagaro, Darryle D. Schoepp, Michael P. Johnson, Thomas H. Large, James A. Monn, Thomas C. Britton, Melvyn Baez
Publikováno v:
Journal of Medicinal Chemistry. 46:3189-3192
This report describes recently discovered novel allosteric modulators of metabotropic glutamate2 (mGlu2) receptors. These pyridylmethylsulfonamides (e.g., 3) potentiate glutamate, shifting agonist potency by 2-fold. This effect was specific for mGlu2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cfce582d17cc9ab1d5c4038c66071f
https://doi.org/10.1021/jm034015u
https://doi.org/10.1021/jm034015u
Autor:
Melvyn Baez, Lisa M. Churgay, Mcclure Don B, Leonard N. Boggs, Patrick C. May, Kimberly S. Fuson, Gerald W. Becker
Publikováno v:
Journal of Neurochemistry. 67:1324-1327
Clusterin is a secreted glycoprotein that is markedly induced in many disease states and after tissue injury. In the CNS, clusterin expression is elevated in neuropathological conditions such as Alzheimer's disease (AD), where it is found associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5ef7a8a615cef73e0e78fb78525847
https://doi.org/10.1046/j.1471-4159.1996.67031324.x
https://doi.org/10.1046/j.1471-4159.1996.67031324.x
Autor:
Melvyn Baez, Harlan E. Shannon, Steven C. Peters, D D Schoepp, Jianliang Yu, Bryan G. Johnson, Anja Köster, M Tian, Yi Wang, Anni-Maija Linden
Publikováno v:
Neuropharmacology. 43:251-259
Pre-synaptic metabotropic glutamate (mGlu) receptors modulate neuronal excitability by controlling glutamate and gamma-aminobutyric acid (GABA) release. The mGlu8 receptor is predominantly found in pre-synaptic terminals and its expression is highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181cba0bdfdb4ce1be86bdad8916e14b
https://doi.org/10.1016/s0028-3908(02)00079-5
https://doi.org/10.1016/s0028-3908(02)00079-5