Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Melvin Reichman"'
Autor:
Arturo Bravo-Nuevo, Alice Marcy, Minzhou Huang, Frank Kappler, Jennifer Mulgrew, Lisa Laury-Kleintop, Melvin Reichman, Annette Tobia, George C Prendergast
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90031 (2014)
Metabolic syndrome, diabetes and diabetes complications pose a growing medical challenge worldwide, accentuating the need of safe and effective strategies for their clinical management. Here we present preclinical evidence that the sorbitol derivativ
Externí odkaz:
https://doaj.org/article/028aec2c386442f4a5d19bc9bf208a09
Autor:
Francesco F. De Pascali, Michael Ippolito, Nathan Hopfinger, Konstantin E. Komolov, Daniela K. Laurinavichyute, Leon A. Sakkal, Ajay P. Nayak, Poli AN. Reddy, Preston S. Donover, Melvin Reichman, Joseph M. Salvino, Raymond B. Penn, Roger S. Armen, Charles P. Scott, Jeffrey L. Benovic
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ca1cb4060d5973b2589d48aaf27a873
https://doi.org/10.1124/jpet.122.147630
https://doi.org/10.1124/jpet.122.147630
Publikováno v:
ASSAY and Drug Development Technologies. 14:240-251
Glycosyltransferase enzymes play diverse metabolic and regulatory roles by catalyzing the transfer of sugar molecules to protein, lipid, and carbohydrate acceptors, and they are increasingly of interest as therapeutic targets in a number of diseases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1a91f47997a7c30c8983835e233c7b
https://doi.org/10.1089/adt.2016.711
https://doi.org/10.1089/adt.2016.711
Preclinical study of the long-range safety and anti-inflammatory effects of high-dose oral meglumine
Autor:
George C. Prendergast, Carol M. Artlett, Melvin Reichman, Annette Tobia, Summer Sedano, Arturo Bravo-Nuevo, Allyson R. Minton, Lisa Laury-Kleintop, Alice Marcy, Kaylend Manley, Susan K. Gilmour
Publikováno v:
Journal of cellular biochemistry.
Meglumine is a methylamino derivative of sorbitol that is an approved drug excipient. Recent preclinical studies suggest that administration of high-dose oral meglumine can exert beneficial medicinal effects to treat diabetes, obesity, and fatty live
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6cf290134abb7c4af85ef8c768d27a
https://pubmed.ncbi.nlm.nih.gov/30809852
https://pubmed.ncbi.nlm.nih.gov/30809852
Autor:
Marlin Yohn, Matthew Sim, Andrew Wright, Amanda R. Schabdach, Preston S. Donover, Melvin Reichman, Chip Allee, Sandesh Gowda
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 16:180-188
The Lankenau Institute for Medical Research Chemical Genomics Center, Inc. has developed a new (patents issued and pending) Nanotube Automated Repository System (NARS) for dynamic storage of millions of 'single-shot' samples stored in a new monolithi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2d3d4c1a4e006402a220b5b8712519
https://doi.org/10.2174/1386207311316030003
https://doi.org/10.2174/1386207311316030003
Autor:
Peter B. Simpson, Melvin Reichman
Publikováno v:
Drug discovery today. 21(5)
Open innovation in pharmaceutical R&D evolved from a triple helix of convergent paradigm shifts in academic, industrial and government research sectors. The birth of the biotechnology sector catalyzed shifts in location dynamics that led to the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a8d4f223217d03e21b1c3e1b1fdb38
https://pubmed.ncbi.nlm.nih.gov/26743597
https://pubmed.ncbi.nlm.nih.gov/26743597
Autor:
Melvin Reichman, Thomas Zielinski, Robert G. Lowery, Amanda R. Schabdach, Lisa Laury-Kleintop, Preston S. Donover, Meera Kumar
Publikováno v:
Journal of biomolecular screening. 20(10)
Ras homologous (Rho) family GTPases act as molecular switches controlling cell growth, movement, and gene expression by cycling between inactive guanosine diphosphate (GDP)- and active guanosine triphosphate (GTP)-bound conformations. Guanine nucleot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df19cfdec56ef41419762d9a3eb8024
https://pubmed.ncbi.nlm.nih.gov/26195453
https://pubmed.ncbi.nlm.nih.gov/26195453
Autor:
Lisa Laury-Kleintop, Alice Marcy, Minzhou Huang, Melvin Reichman, George C. Prendergast, Annette Tobia, Arturo Bravo-Nuevo, Frank Kappler, Jennifer Mulgrew
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e90031 (2014)
PLoS ONE, Vol 9, Iss 2, p e90031 (2014)
Metabolic syndrome, diabetes and diabetes complications pose a growing medical challenge worldwide, accentuating the need of safe and effective strategies for their clinical management. Here we present preclinical evidence that the sorbitol derivativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1417f534a664bb2815dc9190e82eef4
http://europepmc.org/articles/PMC3937407
http://europepmc.org/articles/PMC3937407
Autor:
Melvin Reichman, Peter B. Simpson
Publikováno v:
Nature reviews. Drug discovery. 13(1)
Early-stage drug discovery is rapidly evolving into an endeavour in which scientific research communities in both the public and private sectors are finding new ways to share knowledge, expertise and resources. Here, we discuss some of the challenges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee060ed6ebb96535198388b45210c16c
https://pubmed.ncbi.nlm.nih.gov/24378783
https://pubmed.ncbi.nlm.nih.gov/24378783
Publikováno v:
Endocrinology. 138:3779-3786
Postmenopausal women receiving hormone replacement therapy have a lower risk of coronary heart disease than women who do not receive hormone treatment. Multiple mechanisms are likely to underlie estrogen’s cardioprotective action, including lowerin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f907504326110de91698a8722183fff
https://doi.org/10.1210/endo.138.9.5404
https://doi.org/10.1210/endo.138.9.5404