Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Melvin R. Hayden"'
Autor:
Melvin R. Hayden
Publikováno v:
Neuroglia, Vol 4, Iss 4, Pp 307-328 (2023)
Astrocytes (ACs) are the most abundant cells in the brain and, importantly, are the master connecting and communicating cells that provide structural and functional support for brain cells at all levels of organization. Further, they are recognized a
Externí odkaz:
https://doaj.org/article/d926e59b741e4aa09060006af228220c
Autor:
Melvin R. Hayden
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1463 (2024)
Globally, cerebral microbleeds (CMBs) are increasingly being viewed not only as a marker for cerebral small vessel disease (SVD) but also as having an increased risk for the development of stroke (hemorrhagic/ischemic) and aging-related dementia. Rec
Externí odkaz:
https://doaj.org/article/f3833e70df444888ac7cc30727aa402b
Autor:
Melvin R. Hayden
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 96 (2024)
The recently described perivascular unit (PVU) resides immediately adjacent to the true capillary neurovascular unit (NVU) in the postcapillary venule and contains the normal-benign perivascular spaces (PVS) and pathological enlarged perivascular spa
Externí odkaz:
https://doaj.org/article/6454952538e142ad85f64beca5b09fca
Autor:
Melvin R. Hayden
Publikováno v:
Life, Vol 13, Iss 10, p 1955 (2023)
The brain endothelial cell (BEC) glycocalyx (ecGCx) is a BEC surface coating consisting of a complex interwoven polysaccharide (sweet husk) mesh-like network of membrane-bound proteoglycans, glycoproteins, and glycosaminoglycans (GAGs) covering the a
Externí odkaz:
https://doaj.org/article/4f91331fe60c4c1cb332eff7ccc207d9
Autor:
Melvin R. Hayden
Publikováno v:
Medicina, Vol 59, Iss 7, p 1337 (2023)
Embryonic genetic mechanisms are present in the brain and ready to be placed into action upon cellular injury, termed the response to injury wound-healing (RTIWH) mechanism. When injured, regional brain endothelial cells initially undergo activation
Externí odkaz:
https://doaj.org/article/fb0f7b0996b848b0abf3ef15ff2f3aaa
Autor:
Melvin R. Hayden
Publikováno v:
Medicina, Vol 59, Iss 6, p 1124 (2023)
Brain capillary endothelial cell(s) (BECs) have numerous functions, including their semipermeable interface-barrier (transfer and diffusion of solutes), trophic (metabolic homeostasis), tonic (vascular hemodynamics), and trafficking (vascular permeab
Externí odkaz:
https://doaj.org/article/6cef22d4c5714979acf7581826b09172
Publikováno v:
Medicina, Vol 59, Iss 5, p 917 (2023)
Perivascular spaces (PVS) and their enlargement (EPVS) have been gaining interest as EPVS can be visualized non-invasively by magnetic resonance imaging (MRI) when viewing T-2-weighted images. EPVS are most commonly observed in the regions of the bas
Externí odkaz:
https://doaj.org/article/04d58e850c5343db94084718ac27ee16
Autor:
Melvin R. Hayden
Publikováno v:
Medicina, Vol 59, Iss 3, p 561 (2023)
Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily increasing globally and seems to parallel the increasing prevalence of obesity. It consists of a cluster of risk factors which traditionally includes obesity and hype
Externí odkaz:
https://doaj.org/article/80d4a4f7c7dc4cd3ae80da0c1bb14538
Autor:
Javad Habibi, Annayya R. Aroor, Nitin A. Das, Camila M. Manrique-Acevedo, Megan S. Johnson, Melvin R. Hayden, Ravi Nistala, Charles Wiedmeyer, Bysani Chandrasekar, Vincent G. DeMarco
Publikováno v:
Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-17 (2019)
Abstract Objective Diabetic nephropathy (DN) is characterized by glomerular and tubulointerstitial injury, proteinuria and remodeling. Here we examined whether the combination of an inhibitor of neprilysin (sacubitril), a natriuretic peptide-degradin
Externí odkaz:
https://doaj.org/article/6f54e723c3864b1dbf725c1cbaff7b4d
Autor:
Zhongli Chen, Qiqi Xue, Lijuan Cao, Yanpin Wang, Yuanyuan Chen, Xiaojie Zhang, Fan Xiao, Ying Yang, Melvin R. Hayden, Yan Liu, Ke Yang
Publikováno v:
Mediators of Inflammation, Vol 2021 (2021)
Oxidized low-density lipoprotein (oxLDL) induced a foam-cell-like phenotype of the vascular smooth muscle cells (VSMCs), leading to the inflammatory responses incorporating Toll-like receptor- (Tlr-) mediated cellular alterations. However, the role o
Externí odkaz:
https://doaj.org/article/29cc00efa0d44020b40baf3b07e053d7