Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Melvin K. Spigelman"'
Publikováno v:
Respirology. 15:764-778
Although treatment of drug-susceptible tuberculosis (TB) under ideal conditions may be successful in >or=95% of cases, cure rates in the field are often significantly lower due to the logistical challenges of administering and properly supervising th
Autor:
Julia Nieves, James F. Holland, Shankar Vallabhajosula, P. Alberto Paciucci, Rosemaria Gennuso, Melvin K. Spigelman, Rosario A. Zappulla, Stanley J. Goldsmith, Marco Chinol
Publikováno v:
Cancer Investigation. 11:118-128
In this study of 25 central nervous system (CNS) tumor-bearing rats, the CNS biodistribution of intravenously administered, indium-labeled liposomes was investigated. In 16 animals, the blood-brain barrier and blood-tumor barrier were modified using
Autor:
Melvin K Spigelman
Publikováno v:
The Journal of infectious diseases. 196
Novel chemotherapeutic drugs are needed to improve tuberculosis (TB) control, especially in the developing world. Given the magnitude of the problem and the resources available in countries that have the highest burden of disease, the present standar
Autor:
Melvin K. Spigelman
Publikováno v:
JAMA: The Journal of the American Medical Association. 277:1199
In Reply. —The letter from Dr Spigelman contains several inaccuracies and misconceptions. Treatment guidelines from the leading thyroid societies all were prepared before publication of current data so that current guidelines may need to be updated
Autor:
E. J. Feuer, Raphael P. Davis, R.A. Zappulla, James F. Holland, L. I. Malis, Melvin K. Spigelman
Publikováno v:
Acta Neurochirurgica. 83:138-143
The potential interactive effects between subarachnoid hemorrhage (SAH) and blood brain barrier (BBB) disruption were studied in a rat model. Experimental subarachnoid hemorrhage was produced in twenty rats (experimental group) by the intracisternal
Autor:
James F. Holland, Melvin K. Spigelman, Judith D. Goldberg, Rosario A. Zappulla, Leonard I. Malis, D. Marotta, Stanley J. Goldsmith
Publikováno v:
Cancer Drug Delivery. 1:207-211
The effect of an intracarotid artery infusion of etoposide on blood-brain barrier (BBB) integrity was investigated in a rat model system. The external carotid arteries of Sprague-Dawley rats were catheterized in a retrograde manner. Etoposide in a do
Autor:
James F. Holland, Eric J. Feuer, Leonard I. Malis, Rosario A. Zappulla, Peter H. Hollis, Melvin K. Spigelman
Publikováno v:
Experimental Neurology. 99:428-439
This study investigated the effects of hypertension and water loading on etoposide-induced, reversible blood-brain barrier disruption in a rat model. Twenty-nine animals were divided into four groups: group 1—intracarotid (i.c.) injection of saline
Autor:
Leonard I. Malis, James F. Holland, Stanley J. Goldsmith, Melvin K. Spigelman, Judith D. Goldberg, Rosario A. Zappulla
Publikováno v:
Neurosurgery. 12:606-612
An animal model for prolonged reversible blood-brain barrier (BBB) disruption has been developed. The external carotid arteries of Osborn-Mendel rats were catheterized in a retrograde manner. Varying concentrations of sodium dehydrocholate were infus
Publikováno v:
The American Journal of Medicine. 78:149-152
Squamous cell carcinoma of the tongue tends to be an indolent disease. Tumors that present as small, localized lesions of the anterior tongue have a median five-year survival greater than 70 percent whether treated by irradiation or surgery. Distant
Publikováno v:
Neurosurgery. 18:622-624
Although systemic metastases from transitional cell carcinoma of the bladder occur frequently, involvement of the central nervous system is uncommon. We describe a patient with an isolated cerebral metastasis who had previously undergone resection of