Zobrazeno 1 - 10
of 342
pro vyhledávání: '"Melvin I. Simon"'
Publikováno v:
BioTechniques, Vol 23, Iss 6, Pp 978-982 (1997)
Externí odkaz:
https://doaj.org/article/f254e656bfe147f092315be1ece75e44
Autor:
Anne N. Murphy, Alexander Y. Andreyev, Sandra E. Wiley, Jack E. Dixon, Melvin I. Simon, Robert Karisch, Peter van der Geer, Ting Fen Tsai, Ajit S. Divakaruni, Benjamin G. Neel, Estelle A. Wall, Yi Fan Chen, Guy Perkins
Publikováno v:
EMBO Molecular Medicine
Miner1 is a redox-active 2Fe2S cluster protein. Mutations in Miner1 result in Wolfram Syndrome, a metabolic disease associated with diabetes, blindness, deafness, and a shortened lifespan. Embryonic fibroblasts from Miner1(-/-) mice displayed ER stre
Autor:
Alexander Y. Andreyev, Alejandro P. Heuck, William G. McDonald, Melvin I. Simon, Robert R. Henry, Estelle A. Wall, Theodore P. Ciaraldi, Sandra E. Wiley, Mattias Loviscach, Nagendra Yadava, David A. Ferrick, Ajit S. Divakaruni, Susanna Petrosyan, George W. Rogers, Anne N. Murphy, Jerry R. Colca
Publikováno v:
Proceedings of the National Academy of Sciences. 110:5422-5427
Facilitated pyruvate transport across the mitochondrial inner membrane is a critical step in carbohydrate, amino acid, and lipid metabolism. We report that clinically relevant concentrations of thiazolidinediones (TZDs), a widely used class of insuli
Autor:
Chen Wang, Dario R. Alessi, Eeva Sommer, Melvin I. Simon, Dianqing Wu, Jiyong Wang, Stefan Offermanns, Tohru Kozasa, Xiaoqing Gan, Srinivasa M. Srinivasula
Publikováno v:
Nature cell biology
Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates AGC protein kinases including protein kinase C (PKC) and regulates cellular functions such as cell migration. However, its regulation remains poorly understood. Here we show that lysopho
Autor:
King Wai Yau, Veit Flockerzi, Jenny Hsieh, Shannath L. Merbs, Michael Tri H. Do, T. Yoshioka, Tian Xue, Melvin I. Simon, Z. Jiang, Derek S. Welsbie, Hao Wang, Petra Weissgerber, David E. Clapham, A. Riccio, Marc Freichel, S. Stolz
Publikováno v:
Nature
Non-mammalian vertebrates have an intrinsically photosensitive iris and thus a local pupillary light reflex (PLR). In contrast, it is thought that the PLR in mammals generally requires neuronal circuitry connecting the eye and the brain. Here we repo
Autor:
Hyejung Min, Goon Ho Park, Melvin I. Simon, Dong-Hoon Kim, Se Jeong Kim, Jaekwang Lee, Sang Kyou Han, C. Justin Lee, Sung Joong Lee, Estelle A. Wall
Publikováno v:
Proceedings of the National Academy of Sciences. 108:3371-3376
Despite its clinical importance, the mechanisms that mediate or generate itch are poorly defined. The identification of pruritic compounds offers insight into understanding the molecular and cellular basis of itch. Imiquimod (IQ) is an agonist of Tol
Autor:
Robert A. Rebres, Melvin I. Simon, Leah A. Santat, William E. Seaman, Elliott M. Ross, Finly Philip, Tamara I. A. Roach, Iain D. C. Fraser, Keng Mean Lin, Lucas Cheadle, Christina Moon, Jamie Liu
Publikováno v:
Journal of Biological Chemistry. 286:942-951
Cross-talk between Gα(i)- and Gα(q)-linked G-protein-coupled receptors yields synergistic Ca(2+) responses in a variety of cell types. Prior studies have shown that synergistic Ca(2+) responses from macrophage G-protein-coupled receptors are primar
Autor:
Marilyn R. Kehry, Troy D. Randall, Miguel E. Moreno-García, Kim Kusser, David J. Rawlings, Guixiu Shi, Shirly Becker-Herman, Kelly L. Hudkins, Melvin I. Simon, Denny Liggitt, Michael Tighe, Robert Dunn, Ann Marshak-Rothstein, Betty Mousseau, Ravi S. Misra, Charles E. Alpers, Frances E. Lund, Thi Sau Migone, Anil Thankappan
Publikováno v:
The Journal of Experimental Medicine
Survival of mature B cells is regulated by B cell receptor and BAFFR-dependent signals. We show that B cells from mice lacking the Gαq subunit of trimeric G proteins (Gnaq−/− mice) have an intrinsic survival advantage over normal B cells, even i
Autor:
Melvin I. Simon, Guixiu Shi, Frances E. Lund, Michael Tighe, Santiago Partida-Sanchez, Michael T. Borchers, James J. Lee, Ravi S. Misra
Publikováno v:
The Journal of Experimental Medicine
CD38 controls the chemotaxis of leukocytes to some, but not all, chemokines, suggesting that chemokine receptor signaling in leukocytes is more diverse than previously appreciated. To determine the basis for this signaling heterogeneity, we examined
Autor:
Lyudmila Sikora, Savita P. Rao, K.R. O'Neill, R.S. Pero, Michael T. Borchers, Hiam Abdala-Valencia, H.H. Shen, Sergei I. Ochkur, Karsten Spicher, Melvin I. Simon, Lutz Birnbaumer, Michael P. McGarry, Nancy A. Lee, James J. Lee, P. Sriramarao, Joan M. Cook-Mills
Publikováno v:
Proceedings of the National Academy of Sciences. 104:4371-4376
The trafficking of leukocytes from the blood to sites of inflammation is the cumulative result of receptor-ligand-mediated signaling events associated with the leukocytes themselves as well as with the underlying vascular endothelium. Our data show t