Zobrazeno 1 - 10 of 35 pro vyhledávání: '"Melvin H. Heiffer"'
1
Fatal Neurotoxicity of Arteether and Artemether
Autor: Peter J. Weina, Melvin H. Heiffer, Stephen J. Grate, J. M. Petras, Thomas G. Brewer, James O. Peggins, Brian G. Schuster, Barry S. Levine
Publikováno v: The American Journal of Tropical Medicine and Hygiene. 51:251-259
Artemisinin (qinghaosu) and several derivatives have been developed and are in use as antimalarial drugs but scant information is available regarding animal or human toxicity. Following a eight-day, multiple-dose, pharmacokinetic study of arteether (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451dff8f6974cb5e184d5a4026ef850b
https://doi.org/10.4269/ajtmh.1994.51.251
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2
Neurotoxicity in animals due to arteether and artemether
Autor: Brian G. Schuster, James Swearengen, Peter J. Weina, Melvin H. Heiffer, Stephen J. Grate, J.M. Petras, Barry S. Levine, Thomas G. Brewer, James O. Peggins
Publikováno v: Transactions of the Royal Society of Tropical Medicine and Hygiene. 88:33-36
Several artemisinin (qinghaosu) derivatives have been developed and are in use as antimalarial drugs but scant animal or human toxicity data are available. We noted a progressive syndrome of clinical neurological defects with cardio-respiratory colla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57351de814c6e438919520b5daee01d4
https://doi.org/10.1016/0035-9203(94)90469-3
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3
The pharmacokinetics and bioavailability of dihydroartemisinin, arteether, artemether, artesunic acid and artelinic acid in rats
Autor: Melvin H. Heiffer, Qigui Li, Kelly Masonic, Lawrence Fleckenstein, Thomas G. Brewer, James O. Peggins
Publikováno v: The Journal of pharmacy and pharmacology. 50(2)
The pharmacokinetics and bioavailability of dihydroartemisinin (DQHS), artemether (AM), arteether (AE), artesunic acid (AS) and artelinic acid (AL) have been investigated in rats after single intravenous, intramuscular and intragastric doses of 10 mg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9c960f3f9fd87aecc19a728fe35e36
https://pubmed.ncbi.nlm.nih.gov/9530985
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4
A Multi-Component Solvent System for the Analysis of a Candidate Antimalarial by Normal Phase HPLC
Autor: Melvin H. Heiffer, J. von Bredow, H. Stampfli, J. Osuch
Publikováno v: Journal of Liquid Chromatography. 2:53-65
The new candidate antimalarial WR 180,409·H3PO4 (DL-threo-α-(2-piperidyl)-2-trifluoromethyl-6-(4-trifluoromethylphenyl)-4-pyridinemethanol phosphate) and its internal standard, WR 184,806·H3PO4 (DL-2,8-bis(trifluoromethyl)-4-[1-hydroxy-3-(N-t-buty
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::568ddbd4afdb327c883b93d439c30dd9
https://doi.org/10.1080/01483917908060045
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5
Disposition of the antimalarial, mefloquine, in the isolated perfused rat liver
Autor: Lawrence Fleckenstein, Michael D. Coleman, Melvin H. Heiffer, Lisa A. Shipley
Publikováno v: Biochemical Pharmacology. 37:235-239
The disposition of mefloquine has been investigated in the isolated perfused rat liver (IPRL) preparation after the administration of [14C]mefloquine HCl (3.8 mg, 4 microCi, quinoline ring labeled). Mefloquine underwent avid hepatic uptake within 10
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab13b4b042fdcb63db0c196231df4d3
https://doi.org/10.1016/0006-2952(88)90723-x
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7
The Genesis of the Initial Blood Pressure Peak Following iv Administration of Certain Catecholamines
Autor: Robert William Caldwell, Melvin H. Heiffer
Publikováno v: Experimental Biology and Medicine. 144:89-95
SummaryThe blood pressure changes in response to injection of certain sympathomimetic amines, epinephrine, norepinephrine and isoproterenol have been described many times, yet the genesis of the initial blood pressure peak has not been adequately exp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f0b8df52d05162e5fafcdd03e4007e
https://doi.org/10.3181/00379727-144-37533
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8
Depression of the isolated guinea pig atrium by β-mercaptoethylamine, β-adrenergic blocking agents, and metabolic inhibitors
Autor: David P. Jacobus, Melvin H. Heiffer, Roy L. Mundy, Gale E. Demaree
Publikováno v: Toxicology and Applied Pharmacology. 9:300-308
The depressant actions of β -mercaptoethylamine (MEA) on the electrically driven isolated guinea pig atrium are compared with those of dichloroisoproterenol, pronethalol, propranolol, dl -erythro-4-(2-methylamino-1-hydroxypropyl) methanesulfonanilid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3af8747f91182338bcc9cc28064db6e6
https://doi.org/10.1016/0041-008x(66)90125-6
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9
An Excitatory Adrenergic Alpha Receptor Mechanism of Terminal Guinea-Pig Ileum
Autor: Melvin H. Heiffer, Gale E. Demaree, David G. Reynolds
Publikováno v: Experimental Biology and Medicine. 125:73-78
SummaryExperiments were performed on segments of terminal guinea-pig ileum utilizing differential alpha and beta adrenergic receptor site blocking techniques. Phenyl-ephrine caused a contraction of this segment of guinea-pig intestine which resembled
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3969eeeb43909f1c8650d44fd1a4fc
https://doi.org/10.3181/00379727-125-32017
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